Circulating Lipoprotein-Associated Phospholipase A2 Levels Are Elevated in Obese Children.

Sakka, SD; Pervanidou, P; Lazopoulou, N; Kaminioti, Ch; Kanaka-Gantenbein, Ch.; Chrousos, G. P.; Papassotiriou, I

doi:10.1210/endo-meetings.2010.part2.p15.p2-721

Cited by 4 publications

(6 citation statements)

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“…Our study provides evidence of a strong positive correlation between serum Lp-PLA2 and studied sleep parameters such as AHI, ODI, number of desaturation events and an inverse association with a lowest oxygen saturation and average oxygen saturation. These results are in agreement with two other studies that evaluated Lp-PLA2 levels in OSAS patients that also reported a significant association between circulating Lp-PLA2 concentration and arousal index (34,35). AHI and ODI, as well as arousal index, are good indicators for severity of respiratory events during sleep.…”

Section: Discussionsupporting

confidence: 92%

Serum Lipoprotein-Associated Phospholipase A2 in Males With Metabolic Syndrome and Obstructive Sleep Apnea

et al. 2018

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Context. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel biomarker for cardiovascular diseases (CVD) risk estimation with high specificity for vascular inflammation. Few studies have investigated Lp-PLA2 levels in patients with metabolic syndrome (MetS) and obstructive sleep apnea syndrome (OSAS).Objective. This study aimed to evaluate the role of Lp-PLA2 levels as a marker of vascular inflammation that contributes to cardiometabolic dysfunction in patients with MetS and OSAS.Design. This is a prospective case-control study. Subjects and Methods. 83 men were enrolled. Following anthropometric measurements, laboratory analysis and overnight sleep study, patients were divided into three groups: MetS, OSAS with/without MetS. Serum Lp-PLA2 levels were determined by ELISA method.Results. Serum Lp-PLA2 levels were statistically significant among the three groups and were higher in OSAS with MetS group than those without MetS. A significant positive relationship between increased Lp-PLA2 level and CRP (C-reactive protein) and apnea-hypopnea index (AHI) was found. Average oxygen saturation (AvO 2 ) and the lowest oxygen saturation were negatively correlated with Lp-PLA2. The number of desaturation events, oxygen desaturation index, AvO 2 , AHI and CRP were significant predictors of Lp-PLA2.Conclusions. Lp-PLA2 levels are associated with OSAS severity and might play an important role in predicting CVD in OSAS with/without MetS.

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Section: Discussionsupporting

confidence: 92%

Serum Lipoprotein-Associated Phospholipase A2 in Males With Metabolic Syndrome and Obstructive Sleep Apnea

et al. 2018

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“…Both Lp-PLA 2 activity and mass (concentration) are associated with CAD as well as cerebrovascular outcomes (4). Several large studies including ARIC, WOSCOPS, MONICA, and Rotterdam have demonstrated that Lp-PLA 2 is an independent predictor of CAD (5).…”

Section: Introductionmentioning

confidence: 99%

The role of Lp-PLA2 and biochemistry parameters as potential biomarkers of coronary artery disease in Asian South-Indians: a case-control study

Sairam

Sola

Barooah

et al. 2017

Cardiovasc. Diagn. Ther.

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“…The mean age of the study in the obese male group was older than the lean male group. The median BMI was 31,38 (27,(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)36) kg/m 2 in obese male group, and 22,85 (19,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)8) kg/m 2 in lean male group (Table 1).…”

Section: Resultsmentioning

confidence: 99%

The Differences of Lipoprotein-Associated Phospholipase A2, Apolipoprotein B and Low Density Lipoprotein In Obese and Lean Men

Yuliana

Adipireno

Limijadi

et al. 2021

J. Biomed. Transl. Res.

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Background: An increase in fat accumulation in obesity has been suggested to link with an increase in inflammation. This inflammation may be associated with an elevated of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2), Apolipoprotein B (Apo B), and Low-Density Lipoprotein (LDL), thereby associated with the risk of atherosclerosis.Objective: To investigate the differences between Lp-PLA2, Apo B, and LDL levels in obese and lean men.Methods: A cross-sectional study was conducted on 74 men (obese and lean) at the Faculty of Medicine, Diponegoro University, Indonesia, in 2020. The concentration of LDL was measured using the homogenous enzymatic colourimetric method, whereas the levels of Lp-PLA2 and Apo B were determined using the ELISA method. Data were analyzed using an Independent t-test, setting statistical significance at p <0.05.Results: This study showed that Lp-PLA2 levels were significantly different between obese and lean men (p = 0.039). Furthermore, LDL levels were also significantly different between obese and lean men (p = 0.002). However, we did not find any differences in Apo B between obese and lean men (p = 0.640).Conclusion: Lp-PLA2 and LDL levels were slightly higher in obese compared to lean men, but no difference of Apo B.

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Circulating Lipoprotein-Associated Phospholipase A2 Levels Are Elevated in Obese Children.

Cited by 4 publications

References 0 publications

Serum Lipoprotein-Associated Phospholipase A2 in Males With Metabolic Syndrome and Obstructive Sleep Apnea

Serum Lipoprotein-Associated Phospholipase A2 in Males With Metabolic Syndrome and Obstructive Sleep Apnea

The role of Lp-PLA2 and biochemistry parameters as potential biomarkers of coronary artery disease in Asian South-Indians: a case-control study

The Differences of Lipoprotein-Associated Phospholipase A2, Apolipoprotein B and Low Density Lipoprotein In Obese and Lean Men

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