Circulating levels of pro‐atrial natriuretic peptide in lower respiratory tract infections

Müller, Beat; Süess, Erika; Schuetz, Philipp; Müller, Christian; Bingisser, Roland; Bergmann, Andreas; Stolz, Daiana; Tamm, Michael; Morgenthaler, Nils G.; Christ‐Crain, Mirjam

doi:10.1111/j.1365-2796.2006.01722.x

Cited by 54 publications

(48 citation statements)

References 49 publications

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“…Based on several clinical observational studies, circulating proADM and proANP have lately emerged as useful prognostic tools regarding all-cause mortality, ICU Brought to you by | Universitaetsbibliothek Basel Authenticated Download Date | 10/9/17 4:13 PM admission, severity of illness and disease-specific complications in CAP [9,6,25,[31][32][33]. The present analysis expands these findings by demonstrating a relevant correlation between high proADM and proANP levels and future decline in QoL in CAP patients.…”

Section: Discussionsupporting

confidence: 67%

“…In addition to clinical risk scores, such as the pneumonia severity index (PSI) [13], several inflammatory and/or cardiovascular blood biomarkers such as white blood cells (WBC), C-reactive protein (CRP), procalcitonin (PCT), pro-adrenomedullin (proADM), as well as pro-atrial natriuretic peptide (proANP) have been found helpful for risk prediction [6,[14][15][16][17][18][19][20]. Particularly, proADM [9,6,[21][22][23][24][25][26][27][28][29][30], proANP [9,6,25,[31][32][33] and PCT [10,22,25,31,[34][35][36] have been associated with risk for shortand long-term all-cause mortality as well as other adverse outcomes, such as severity of illness, admission to the intensive care unit (ICU), and disease-specific complications. Yet, there is insufficient evidence whether these clinical parameters and blood biomarkers are also helpful in predicting more subjective QoL outcomes: mens sana in corpore sano?…”

Section: Introductionmentioning

confidence: 99%

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Prospective evaluation of biomarkers for prediction of quality of life in community-acquired pneumonia

Nickler

Schaffner

Ottiger

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Most clinical research investigated prognostic biomarkers for their ability to predict cardiovascular events or mortality. It is unknown whether biomarkers allow prediction of quality of life (QoL) after survival of the acute event. Herein, we investigated the prognostic potential of well-established inflammatory/cardiovascular blood biomarkers including white blood cells (WBC), C-reactive protein (CRP), procalcitonin (PCT), pro-adrenomedullin (proADM) and pro-atrial natriuretic peptide (proANP) in regard to a decline in QoL in a well-defined cohort of patients with community-acquired pneumonia (CAP). Methods: Within this secondary analysis including 753 patients with a final inpatient diagnosis of CAP from a

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of biomarkers for prediction of quality of life in community-acquired pneumonia

Nickler

Schaffner

Ottiger

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…In CAP, the MR-pro-ANP level may mirror both the inflammatory cytokine response, correlated with the severity of pneumonia, as well as the presence of disease-relevant comorbidities, namely heart failure and renal dysfunction [110][111][112][113]. Therefore, the current authors investigated MR-pro-ANP levels in a well-defined cohort of 545 consecutive patients with LRTI, in order to evaluate its prognostic use for the severity of disease and outcome; this study had two main findings [101]. First, plasma MR-pro-ANP levels were increased in LRTI, with the highest levels in CAP.…”

Section: Biomarkers For the Prognostic Assessment Of Capmentioning

confidence: 99%

Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators

Christ‐Crain¹,

Müller²

2007

European Respiratory Journal

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Used appropriately, biomarkers improve the assessment of respiratory tract infections and sepsis. Most prominently, circulating procalcitonin levels increase by a factor of several tens of thousands during sepsis. Using a sensitive assay, procalcitonin safely and markedly reduces antibiotic usage in respiratory tract infections and nonbacterial meningitis. Procalcitonin is the protopye of hormokine mediators. The term ''hormokine'' encompasses the cytokine-like behaviour of hormones during inflammation and infections. The concept is based on a ubiquitous expression of calcitonin peptides during sepsis. Adrenomedullin, another member of the calcitonin peptide superfamily, was shown to complement and improve the current prognostic assessment in lower respiratory tract infections. Other peptides share some features of hormokines, e.g. natriuretic peptide and copeptin. Hormokines are not only biomarkers of infection but are also pivotal inflammatory mediators. Like all mediators, their role during systemic infections is basically beneficial, possibly to combat invading microbes. However, at increased levels they can become harmful for their host. Multiple mechanisms of action were proposed. In several animal models the modulation and neutralisation of hormokines during infection was shown to improve survival, and thus might open new treatment options for severe infections, especially of the respiratory tract.

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“…N-terminal proANP has shown to be of prognostic relevance in cardiovascular disease and myocardial infarction [11]. Furthermore, a significant difference in proANP levels between survivors and nonsurvivors has been assessed in respiratory tract infections including pneumonia, sepsis and VAP [12][13][14][15].…”

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confidence: 99%

Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP

Boeck¹,

Eggimann²,

Smyrnios³

et al. 2010

European Respiratory Journal

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Ventilator-associated pneumonia (VAP) affects mortality, morbidity and cost of critical care. Reliable risk estimation might improve end-of-life decisions, resource allocation and outcome. Several scoring systems for survival prediction have been established and optimised over the last decades. Recently, new biomarkers have gained interest in the prognostic field. We assessed whether midregional pro-atrial natriuretic peptide (MR-proANP) and procalcitonin (PCT) improve the predictive value of the Simplified Acute Physiologic Score (SAPS) II and Sequential Related Organ Failure Assessment (SOFA) in VAP.Specified end-points of a prospective multinational trial including 101 patients with VAP were analysed. Death ,28 days after VAP onset was the primary end-point.MR-proANP and PCT were elevated at the onset of VAP in nonsurvivors compared with survivors (p50.003 and p50.017, respectively) and their slope of decline differed significantly (p50.018 and p50.039, respectively). Patients with the highest MR-proANP quartile at VAP onset were at increased risk for death (log rank p50.013). In a logistic regression model, MR-proANP was identified as the best predictor of survival. Adding MR-proANP and PCT to SAPS II and SOFA improved their predictive properties (area under the curve 0.895 and 0.880).We conclude that the combination of two biomarkers, MR-proANP and PCT, improve survival prediction of clinical severity scores in VAP.

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Circulating levels of pro‐atrial natriuretic peptide in lower respiratory tract infections

Abstract: Abstract. Mü ller B, Sü ess E, Schuetz P, Mü ller C,

Cited by 54 publications

References 49 publications

Prospective evaluation of biomarkers for prediction of quality of life in community-acquired pneumonia

Prospective evaluation of biomarkers for prediction of quality of life in community-acquired pneumonia

Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators

Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP

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