2007
DOI: 10.1183/09031936.00166106
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Abstract: Used appropriately, biomarkers improve the assessment of respiratory tract infections and sepsis. Most prominently, circulating procalcitonin levels increase by a factor of several tens of thousands during sepsis. Using a sensitive assay, procalcitonin safely and markedly reduces antibiotic usage in respiratory tract infections and nonbacterial meningitis. Procalcitonin is the protopye of hormokine mediators. The term ''hormokine'' encompasses the cytokine-like behaviour of hormones during inflammation and inf… Show more

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Cited by 218 publications
(152 citation statements)
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“…As crianças são mais suscetíveis a infecções respiratórias devido a características anatômicas, fisiológicas e imunológicas 4 . Essas infecções respiratórias têm um impacto significativo na área da saúde em todo o mundo, sendo predominantemente de origem viral 5 .…”
Section: Introductionunclassified
“…As crianças são mais suscetíveis a infecções respiratórias devido a características anatômicas, fisiológicas e imunológicas 4 . Essas infecções respiratórias têm um impacto significativo na área da saúde em todo o mundo, sendo predominantemente de origem viral 5 .…”
Section: Introductionunclassified
“…This makes PCT a more specific marker for bacterial infection. 13 Thus, during severe bacterial infections, the level of PCT may rise several hundred-folds and may even reach a level of 1000 ng/mL without any change in serum calcitonin level. 11,14 However, it is important to keep in mind the following situations while interpreting PCT reports: (i) Gram negative bacteraemias cause higher elevation of PCT than those caused by Gram positive pathogens; 15 (ii) there is a low or negligible rise in PCT levels in localized infections, and in infections caused by viruses or intracellular bacteria; 16,17 and (iii) in the neonatal period, particularly in the first 48-72 hours of life, serum PCT levels increase to a high level and then gradually fall during the first week.…”
Section: Procalcitonin: Structure and Synthesismentioning
confidence: 99%
“…Biomarkers have shown to be very effective in aiding diagnosis and management of hospital patients with suspected systemic bacterial infections, including community-acquired pneumonia (CAP) and sepsis [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Procalcitonin (PCT) is a novel and effective marker of assumed bacterial infections that safely helps guide antibiotic therapy in acute respiratory tract infections (ARI) and sepsis in hospitals [5,[29][30][31][32][33][34][35][36][37][38][39][40].…”
Section: Introductionmentioning
confidence: 99%