Circulating levels of Elabela in pregnant women complicated with intrauterine growth restriction

Behram, Mustafa; Oğlak, Süleyman Cemil; Dağ, İsmail

doi:10.1016/j.jogoh.2021.102127

Cited by 22 publications

(24 citation statements)

References 34 publications

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“…On the other hand, Van Mieghem et al [ 162 ] showed that the apelin serum level was 30% lower in women with IUGR pregnancies compared with uncomplicated pregnancies; apelin mRNA expression in the placenta was similar for both groups. New research has also shown that maternal serum ELABELA was downregulated compared with control, and positively correlated with birth weight [ 163 ].…”

Section: Placental Pathology and Pregnancy Pathologymentioning

confidence: 99%

“…To sum up, the literature data on the apelinergic system in a complicated pregnancy with IUGR are quite insightful. However, the studies conducted so far indicated that significant changes in the levels of apelin/ELABELA have been observed in the placenta, maternal serum, and the foetus during IUGR pregnancy [ 157 , 158 , 159 , 160 , 161 , 162 , 163 ]. These studies suggested that manipulating the levels of apelinergic proteins may be important in restoring the normal course of pregnancy, thanks to which the foetal development will return to the right path.…”

Section: Placental Pathology and Pregnancy Pathologymentioning

confidence: 99%

“…Similarly, a nonobvious result was obtained in the context of the plasma level of ELABELA in women with PE in relation to normal pregnancies [ 147 ]. Apelin serum levels were 30% lower in women with IUGR pregnancies compared with uncomplicated pregnancies, while the adipokine mRNA expression in the placenta was similar in both groups [ 163 ]. Moreover, in this pathology, the ELABELA level in maternal serum was downregulated compared with control and positively correlated with birth weight [ 162 ].…”

Section: Perspectivesmentioning

confidence: 99%

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Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development—An Overview

Dawid

Mlyczyńska

Jurek

et al. 2021

Cells

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The apelinergic system, which includes the apelin receptor (APJ) as well as its two specific ligands, namely apelin and ELABELA (ELA/APELA/Toddler), have been the subject of many recent studies due to their pleiotropic effects in humans and other animals. Expression of these factors has been investigated in numerous tissues and organs—for example, the lungs, heart, uterus, and ovary. Moreover, a number of studies have been devoted to understanding the role of apelin and the entire apelinergic system in the most important processes in the body, starting from early stages of human life with regulation of placental function and the proper course of pregnancy. Disturbances in the balance of placental processes such as proliferation, apoptosis, angiogenesis, or hormone secretion may lead to specific pregnancy pathologies; therefore, there is a great need to search for substances that would help in their early diagnosis or treatment. A number of studies have indicated that compounds of the apelinergic system could serve this purpose. Hence, in this review, we summarized the most important reports about the role of apelin and the entire apelinergic system in the regulation of placental physiology and pregnancy.

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Section: Placental Pathology and Pregnancy Pathologymentioning

confidence: 99%

Section: Placental Pathology and Pregnancy Pathologymentioning

confidence: 99%

Section: Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development—An Overview

Dawid

Mlyczyńska

Jurek

et al. 2021

Cells

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“…[4,5] In a healthy pregnancy, highly invasive extravillous trophoblast (EVT) cells migrate through the uterine wall, erode the spiral arteries, remodel these arteries by replacing the vascular endothelial and muscle cells, and transforming them into the low resistant vessels to provide high blood flow capacity. [6,7] If any EVT cells' migration and invasion characteristics are defected or disturbed, it could result in a shallow invasion of EVT cells into the decidua and vessels, accompanied by inadequate remodeling of the maternal vascular structures seen in the preeclamptic placenta. [8][9][10][11][12] This incomplete remodeling induces uteroplacental insufficiency and fetal growth restriction, which could affect placental development and angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Anjiyojenik protein Cyr61’in ekspresyonu, erken başlangıçlı preeklampsi hastalarının idrarında önemli ölçüde artar

Behram

Oğlak

2021

Journal of Contemporary Medicine

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This study sought to compare the expression of the Cysteinerich 61 (Cyr61) protein in the urine of early-onset preeclampsia (PE) patients with that of the urine of normotensive healthy pregnant women. Material and Method:A total of 80 patients who gave birth from June 2019 to December 2019 were enrolled in this prospective study. The study group comprised 40 pregnant women at 20-34 weeks of gestation who presented with early-onset PE. Gestational age-and body mass index-matched, 40 healthy normotensive pregnant women without proteinuria were included in the control group. We recorded demographic characteristics and urine Cyr61 concentrations of the participants. Results:The urine Cyr61 protein levels were significantly higher in the early-onset PE group (922.6±1263.1 pg/mL) than those of the control group (499.2±270.2 pg/mL, p<0.001). As a result of the ROC analysis, the area under the curve (aHR=0.690, 95% CI=0.556-0.813) was found to be significant (p=0.003). So, it was seen that Cyr61 could be used for the diagnosis of early-onset PE. The values 981.52 pg/mL and above, corresponding to 67.5% of sensitivity and 72.5% of specificity points, can be used as a cut-off which is calculated by the Youden index, can be used to diagnose early-onset PE. Conclusion:This study found an increased Cyr61 protein level in the urine of the early-onset PE patients compared with the urine of healthy pregnancies. The increased presence of Cyr61 protein in the urine could serve as a predictive tool for the early diagnosis of early-onset PE and renal ischemia.

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“…1 In addition to their obstetric and perinatal risks, APs are related to educational, parenting, and mental health problems. [2][3][4][5][6] The dual biological transitions of pregnancy and adolescence might elevate the stress levels and the physical and psychological vulnerability of the person. 7 Also, AP frequently happens within circumstances of risk, which expose adolescent females to various causes of psychosocial trou-ble and difficulties in reaching support and care.…”

mentioning

confidence: 99%

The Prevalence and Associated Factors of Fear of Childbirth Among Pregnant Adolescents in Turkey: A Cross-Sectional Study

Ölmez¹,

Oğlak²

2021

J Clin Obstet Gynecol

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Adolescent pregnancy (AP) has notable economic and social effects for the adolescents concerned, their kids, their parents, and society as a whole. 1 In addition to their obstetric and perinatal risks, APs are related to educational, parenting, and mental health problems. [2][3][4][5][6] The dual biological transitions of pregnancy and adolescence might elevate the stress levels and the physical and psychological vulnerability of the person. 7 Also, AP frequently happens within circumstances of risk, which expose adolescent females to various causes of psychosocial trou-ble and difficulties in reaching support and care. 8 In Turkey, adolescent births constitute about 8.8% of all births. 9 Given these risks and high rates, it is crucial how to prevent mental health challenges in this vulnerable population. 7 The transition from being pregnant to the labor process is related to elevated levels of anxiety, stress, and emotion. Given the unpredictable level of pain and other uncertainties of this process, it is expected for pregnant patients to experience worries and fear regarding the delivery process. 10 Fear of childbirth

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Circulating levels of Elabela in pregnant women complicated with intrauterine growth restriction

Cited by 22 publications

References 34 publications

Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development—An Overview

Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development—An Overview

Anjiyojenik protein Cyr61’in ekspresyonu, erken başlangıçlı preeklampsi hastalarının idrarında önemli ölçüde artar

The Prevalence and Associated Factors of Fear of Childbirth Among Pregnant Adolescents in Turkey: A Cross-Sectional Study

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