Anjiyojenik protein Cyr61’in ekspresyonu, erken başlangıçlı preeklampsi hastalarının idrarında önemli ölçüde artar

Abstract

This study sought to compare the expression of the Cysteinerich 61 (Cyr61) protein in the urine of early-onset preeclampsia (PE) patients with that of the urine of normotensive healthy pregnant women. Material and Method:A total of 80 patients who gave birth from June 2019 to December 2019 were enrolled in this prospective study. The study group comprised 40 pregnant women at 20-34 weeks of gestation who presented with early-onset PE. Gestational age-and body mass index-matched, 40 healthy normotensive pregnant women without proteinuria were included in the control group. We recorded demographic characteristics and urine Cyr61 concentrations of the participants. Results:The urine Cyr61 protein levels were significantly higher in the early-onset PE group (922.6±1263.1 pg/mL) than those of the control group (499.2±270.2 pg/mL, p<0.001). As a result of the ROC analysis, the area under the curve (aHR=0.690, 95% CI=0.556-0.813) was found to be significant (p=0.003). So, it was seen that Cyr61 could be used for the diagnosis of early-onset PE. The values 981.52 pg/mL and above, corresponding to 67.5% of sensitivity and 72.5% of specificity points, can be used as a cut-off which is calculated by the Youden index, can be used to diagnose early-onset PE. Conclusion:This study found an increased Cyr61 protein level in the urine of the early-onset PE patients compared with the urine of healthy pregnancies. The increased presence of Cyr61 protein in the urine could serve as a predictive tool for the early diagnosis of early-onset PE and renal ischemia.

Maternal and neonatal outcomes of expectantly managed pregnancies with previable preterm premature rupture of membranes

“…Inflammation‐oxidative stress axis acts a crucial role in the pathogenesis of diverse obstetric complications, including PPROM 16,27–30 . The prognostic value of systemic inflammatory markers, including NLR and PLR, in many diseases, such as early pregnancy loss, membrane rupture, and HCA, has already been demonstrated in several studies 19,31,32 .…”

First Trimester Mean Platelet Volume, Neutrophil to Lymphocyte Ratio, and Platelet to Lymphocyte Ratio Values Are Useful Markers for Predicting Preeclampsia

“…During a healthy pregnancy, the balance between T helper 1 (Th1) and Th2 immune cells and their immune responses is crucial for maintaining gestation. 18,19 A healthy pregnancy is thought to be a state with Th2 predominance, which provides an immunotolerant setting for fetal rejection prevention. 20 However, in preeclamptic patients, placental ischemia as a result of shallow trophoblast invasion increases proinflammatory CD4+ T cells and reduces regulatory T helper cells.…”

The evaluation of the antepartum and intrapartum risk factors in predicting the risk of birth asphyxia

“…In developed countries, the incidence is two per 1000 live births, while ranges between 3.1%–56.9% in African countries 3,4 . Previous studies reported numerous contributing factors of birth asphyxia, including antepartum risk factors (gestational hypertensive disorders, advanced maternal age, adolescent pregnancies, antepartum hemorrhage, anemia, low educational status, history of neonate with birth asphyxia), intrapartum risk factors (giving birth at home, the prolonged second stage of labor, malpresentation, meconium‐stained amniotic fluid [MSAF]), and fetal risk factors (fetal distress, preterm birth, tight nuchal cord, multiple pregnancies) 5–10 …”

“…3,4 Previous studies reported numerous contributing factors of birth asphyxia, including antepartum risk factors (gestational hypertensive disorders, advanced maternal age, adolescent pregnancies, antepartum hemorrhage, anemia, low educational status, history of neonate with birth asphyxia), intrapartum risk factors (giving birth at home, the prolonged second stage of labor, malpresentation, meconium-stained amniotic fluid [MSAF]), and fetal risk factors (fetal distress, preterm birth, tight nuchal cord, multiple pregnancies). [5][6][7][8][9][10] Birth asphyxia refers to a blood flow interruption to the placenta in the period immediately before, during, or following the delivery process, leading to hypoxia and ischemia. If the lack of blood flow persists for quite a while, it may cause persistent neurologic damage, which may ultimately evolve into neurodevelopmental disorders, including neurodevelopmental delay, intellectual disabilities, seizures, hypoxic-ischemic encephalopathy (HIE), and cerebral palsy.…”