Circulating Levels and Breast Cyst Fluid Concentrations of Human Chorionic Gonadotropin, Progesterone and Testosterone in Women with Gross Cystic Breast Disease

Recchione, C; Fariselli, G; E, Grignolio; S, Di Pietro

doi:10.1177/030089168407000609

Cited by 9 publications

(1 citation statement)

References 9 publications

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“…Estrogens do not modulate EGF expression [193] whereas progesterone depresses the androgen-stimulated synthesis [199]. Epithelial membrane antigen (EMA) [123] a-Fetoprotein [173] b-Human chorionic gonadotropin (b-hCG) [173,176,[181][182][183][184][185] Mucinous carcinoma associated antigen (MCA) [186] Prostate-specific antigen (PSA) [162][163][164][165][166][167][168][169][170][171] Tissue-polypeptide antigen (TPA) [176] Tissue-polypeptide specific antigen (TPS) [187,188] Tumor-associated glycoprotein 72 (CA72 or TAG-72)…”

Section: Growth Factors and Their Binding Proteinsmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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For more than one and a half century the cystic disease of the breast has been recognized as the most frequent female benign breast lesion. Although some conundrums and controversies exist about the relation between gross cysts and breast cancer, recent evidence suggests that the multidisciplinary study of gross cystic breast disease (GCBD) may be a powerful tool for predicting the natural history of the multifaceted gross cyst pathology. A lot of papers have been published on breast cyst fluids (BCF) concerning biochemical, hormonal and morphological aspects, demonstrating that the intracystic fluid contains a wide variety of components (such as ions, lipids, proteins, enzymes, growth factors and antigens) and suggesting that their profile provides additional knowledge on both physiopathology and etiologic pathways of human gross cystic breast disease. The aim of this overview is the critical evaluation of all data accumulated in the last thirty years, in order to highlight the utility of biochemical and epidemiological studies to identify gross cysts, if any, at higher breast cancer risk.

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Section: Growth Factors and Their Binding Proteinsmentioning

confidence: 99%

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Mannello

Tonti

Papa

2005

Breast Cancer Res Treat

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EGF in breast cyst fluid: Relationships with intracystic androgens, estradiol and progesterone

Boccardo¹,

Torrisi²,

Zanardi³

et al. 1991

Intl Journal of Cancer

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The relationship between intracystic levels of epidermal growth factor (EGF) and those of dehydroepiandrosterone sulphate (DHEA-S), delta-4-androstenedione (delta-4-A), 17-beta-estradiol (17-beta-E) and progesterone (PROG) have been studied in 77 breast cyst fluid (BCF) samples. EGF and all tested hormones appeared to be inversely correlated with the intracystic Na+/K+ ratio (p less than 0.001). Consequently, when the BCFs were subdivided according to the Na+/K+ ratio, significantly higher levels of EGF, DHEA-S, delta-4-A, 17-beta-E and PROG were found in Na+/K+ less than 3 BCFs compared with Na+/K+ greater than 3 BCFs (p less than 0.001 in all cases). Strong direct relationships were found among all steroid hormones when they were correlated to one another (p less than 0.001). Intracystic EGF concentration was directly and significantly correlated with each tested hormone (p less than 0.001). However, the relationship between EGF and steroid hormones appeared to be different in the 2 BCF types (Na+/K+ less than 3 or greater than 3).

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Breast cyst fluid concentrations of beta-endorphin, steroids and gonadotrophins in premenopausal women with gross cystic disease

et al. 1991

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Circulating Levels and Breast Cyst Fluid Concentrations of Human Chorionic Gonadotropin, Progesterone and Testosterone in Women with Gross Cystic Breast Disease

Cited by 9 publications

References 9 publications

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

Human gross cyst breast disease and cystic fluid: bio-molecular, morphological, and clinical studies

EGF in breast cyst fluid: Relationships with intracystic androgens, estradiol and progesterone

Breast cyst fluid concentrations of beta-endorphin, steroids and gonadotrophins in premenopausal women with gross cystic disease

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