Circulating leptin concentrations can be used as a surrogate marker of fat mass in acute spinal cord injury patients

Maı̈moun, Laurent; Puech, A; Manetta, J.; Badiou, Stéphanie; Paris, Françoise; Ohanna, F; Rossi, Michel; Sultan, Charles

doi:10.1016/j.metabol.2004.03.005

Cited by 32 publications

(24 citation statements)

References 30 publications

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“…Only one of the selected study followed patients for 48 weeks. 3 All the other studies were comparative cross-sectional with existence of a matched control group. Agreement of study inclusion by Cohen Kappa was satisfactory (0.8).…”

Section: Resultsmentioning

confidence: 99%

“…Leptin may also play a part in developing insulin resistance, 5 glucose intolerance 6 and increased cardiovascular diseases risks 7,8 so understanding the alterations of its plasma concentration after SCI may lighten new points in this field. In patients with spinal cord injury (SCI) the elevated level of leptin in serum has been previously reported 3,4,[9][10][11] but still the need of a combined analysis of changes in leptin concentration in spinal cord injured patients thorough systematic reviews and Meta analysis were felt. Although the investigations on leptin effects and changes after spinal cord injury are extremely limited, a constant agreement on elevated level of leptin in this group of patients is noticeable.…”

Section: Introductionmentioning

confidence: 99%

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Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis

et al. 2013

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Objective: The aim of this study was to investigate changes of leptin concentration in plasma in patients with spinal cord injury to come to a single concept by using a Meta-analysis. Setting: Systematic Review. Methods: Searching relevant articles was performed in Ovid data base, Medline (PubMed) EMBASE, Google Scholar, Cochrane and Scopus up to February 2013. Five articles were selected using two independent reviewers. Analysis were performed using SPSS version 18 and Comparative Meta-analysis software version 2.0. Results: The combined analysis with confidence interval of 95% using comprehensive meta-analysis showed significant higher leptin levels in patients with spinal cord injury in comparison with able bodies (Po0.0001). The effect of spinal lesion level on plasma leptin concentration was also statistically significant (Po0.0001). Body mass index was positively related to plasma leptin concentration in both groups (Po0.0001).Conclusion: This Meta analysis approves increased level of leptin in spinal cord injured patients which can be due to fat distribution changes and sympathetic dysfunction in these patients. Our results also showed that patients with higher spinal lesion level have higher plasma leptin concentration.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis

et al. 2013

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“…16 Among SCI individuals, several univariate analyses have shown that leptin levels are positively associated with BMI and FM. 17 Additionally, Mamoun et al 17 reported that the leptin levels increased gradually from week 24 after injury. Although in the present study, plasma adiponectin, plasma PAI-1 and homeostasis model assessment of insulin resistance were related to abdominal obesity, only the plasma leptin level was an independent determinant of abdominal obesity in multiple regression models.…”

Section: Discussionmentioning

confidence: 99%

Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury

et al. 2008

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Study Design: Cross-sectional comparison. Objective: The mortality rate is higher in individuals with spinal cord injury (SCI), and one major cause is cardiovascular disease (CVD). In the general population, the metabolic syndrome (MetS) is associated with an increased risk of CVD, and abdominal obesity is a major feature. Adipokines, secreted by adipose tissue, contribute to obesity-linked metabolic diseases. The aim of this study is to evaluate the prevalence of MetS, the components of this syndrome, especially body composition, and the relations between adipokines and body composition, in SCI individuals. Setting: Kanagawa Rehabilitation Hospital, Kanagawa, Japan. Methods: Forty-four male SCI individuals (57±13 years and 28 paraplegia) and age-matched ablebodied controls were studied. Body composition was assessed by dual-energy X-ray absorptiometry (DXA) and anthropometry (waist circumference). The visceral fat area (VFA) was measured by computed tomography (CT). Plasma adipokine levels, including that of leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1), were measured. Results: Overall, 43% of SCI individuals met the criteria for MetS. Total and regional fat mass (FM), as well as VFA, were higher, whereas total and regional lean mass, except for arm, were lower than ablebodied controls. In the SCI, leptin and PAI-1 levels were positively associated and adiponectin levels were negatively associated with waist circumference, VFA and trunk FM. In multiple regression models, only leptin level was independently associated with waist circumference, VFA and trunk FM. Conclusion: SCI individuals were predisposed to excessive abdominal obesity, and higher leptin levels were strongly associated with higher prevalence of abdominal obesity in this population.

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“…The absence of published reports of vertebral fractures in these patients lends support to our findings. Moreover, the disturbance in hormone secretion could be implicated in other mechanisms such as abnormalities in spermatogenesis 24 and it may exacerbate the adverse lipid profile and body composition changes, 35 since testosterone replacement therapy was demonstrated to attenuate the alterations in myofibrillar proteins from SCI. 36 Our data showed that GH-IGF-I levels were not altered during the early stages following SCI.…”

Section: Discussionmentioning

confidence: 99%

“…At 3 months, all the patients with SCI were using manual or electrical wheelchairs. The able-bodied control group comprised 12 age-matched healthy males with a mean age of 2774.2 years (range [22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Subjectsmentioning

confidence: 99%

The role of androgens or growth factors in the bone resorption process in recent spinal cord injured patients: a cross-sectional study

et al. 2006

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Study design: This cross-sectional study compared the androgen and growth factor profiles and the bone turnover of patients with spinal cord injury (SCI) versus able-bodied controls (AB). Objective: Determine whether androgens, GH, or either IGF-I or IGFBP-3, are implicated in bone turnover alteration in patients with recent SCI. Setting: Propara Center, Montpellier, France. Methods: In all, 16 men (31.3 years) with complete SCI, seven paraplegics and nine tetraplegics, who had sustained injury an average of 3 months earlier, and 12 AB who served as controls (27.5 years) participated. Androgens, growth hormone and its mediators were investigated. The bone resorption process was evaluated by urinary and plasma type I collagen C-telopeptide (CTXu, CTXp), while bone formation was evaluated by osteocalcin (OC) and bone alkaline phosphatase. Results: Total testosterone (TT) and the free androgen index (FAI) were significantly lower in the SCI patients, whereas FSH was significantly higher (Po0.05). These hormonal variations were not related to the level of neurological lesion. There was no significant difference in GH, IGF-I, or IGFBP-3 levels. CTXu and CTXp indicated high bone resorption activity in the SCI patients (Po0.05). Regarding bone formation markers, only OC was affected by neurological lesion (Po0.05). Basal hormone levels did not correlate with markers of bone turnover. Conclusion: The high bone resorption process observed in SCI patients did not seem directly related to testicular endocrine abnormalities or an altered growth factor profile. Nevertheless, the reduced TT and FAI levels could be aggravating factors in the development of acute bone loss.

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Circulating leptin concentrations can be used as a surrogate marker of fat mass in acute spinal cord injury patients

Cited by 32 publications

References 30 publications

Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis

Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis

Serum leptin, abdominal obesity and the metabolic syndrome in individuals with chronic spinal cord injury

The role of androgens or growth factors in the bone resorption process in recent spinal cord injured patients: a cross-sectional study

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