Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis

Latifi, Sahar; Koushki, Davood; Javidan, Abbas Norouzi; Matin, Marzieh; Sabour, Hadis

doi:10.1038/sc.2013.82

Cited by 18 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IP10-deficient mice have been shown to have decreased proliferation and weaker IFN-γ secretion in response to immune challenge. On the other hand, leptin is a potent regulator of energy intake and expenditure, and has also been shown to suppress splenic T-cell function through the activation of corticotropin-releasing hormone [19,20,21]. Further, CORT has been shown to promote leptin secretion.…”

Section: Discussionmentioning

confidence: 99%

Incomplete Spinal Cord Injury Reverses the Level-Dependence of Spinal Cord Injury Immune Deficiency Syndrome

Hong

Chang

Liu

et al. 2019

IJMS

View full text Add to dashboard Cite

Spinal cord injury (SCI) is associated with an increased susceptibility to infections, such as pneumonia, which is the leading cause of death in these patients. This phenomenon is referred to as SCI immune deficiency syndrome (SCI-IDS), and has been shown to be more prevalent after high-level transection in preclinical SCI models. Despite the high prevalence of contusion SCIs, the effects of this etiology have not been studied in the context of SCI-IDS. Compared to transection SCIs, which involve a complete loss of supraspinal input and lead to the disinhibition of spinally-generated activity, contusion SCIs may cause significant local deafferentation, but only a partial disruption of sympathetic tone below the level of injury. In this work, we investigate the effects of thoracic (T6-7) and cervical (C6-7) moderate–severe contusion SCIs on the spleen by characterizing splenic norepinephrine (NE) and cortisol (CORT), caspase-3, and multiple inflammation markers at 3- and 7-days post-SCI. In contrary to the literature, we observe an increase in splenic NE and CORT that correspond to an increase in caspase-3 after thoracic SCI relative to cervical SCI. Further, we found differences in expression of leptin, eotaxin, IP-10, and IL-18 that implicate alterations in splenocyte recruitment and function. These results suggest that incomplete SCI drastically alters the level-dependence of SCI-IDS.

show abstract

Section: Discussionmentioning

confidence: 99%

Incomplete Spinal Cord Injury Reverses the Level-Dependence of Spinal Cord Injury Immune Deficiency Syndrome

Hong

Chang

Liu

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Obesity, sedentary behavior, and sarcopenia are all prevalent after spinal cord injury (SCI). Several studies have reported that people with SCI have higher leptin levels than non-injured controls [ 10 , 17 – 22 ]. These results are consistent with known body composition changes that occur after SCI, including increased total fat mass and lower lean mass [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study

et al. 2018

View full text Add to dashboard Cite

Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. We assessed body composition leptin, adiponectin, and IL-6 levels in 205 men with chronic spinal cord injury. We found no association between age, injury duration, injury level, injury completeness, or walking status and leptin. There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat. Adjusting for body composition, leptin levels were positively associated with IL-6 and negatively associated with adiponectin levels. When considering men with SCI and sarcopenic obesity, only fat mass remained positively associated with leptin. We found no association between IL-6, adiponectin, or lean mass and leptin in the sarcopenic obesity group. Our findings suggest that lean mass is an under recognized, but substantial, source of circulating leptin. Furthermore, SCI-related sarcopenic obesity may result in dysregulated adipo-myokine metabolism with local and systemic physiologic effects.

show abstract

“…Besides changes in fat distribution, higher injury level is also associated with higher leptin level. 11 As it has been mentioned, the baseline level of leptin affects changes of leptin as a response to omega-3 consumption. Although injury level showed no relationship with leptin level among the treatment and control groups in our study, it is essential to consider these factors to obtain a better understanding about the effect of omega-3 on the association between leptin and weight.…”

mentioning

confidence: 99%

“…[4][5][6] Previously, changes in leptin concentration after SCI was reported and most studies have illustrated higher level of leptin in these patients. [7][8][9][10][11] Besides its effects on bone mineral density, it has been shown that leptin and adiponectin may be associated with the risk of cardiovascular diseases (CVDs) because they may affect inflammatory factors. Differences in concentration of leptin among men and women and also its association with age support the probable relationship between leptin level and risk of CVD.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 fatty acids’ effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial

Sabour

Javidan

Latifi

et al. 2014

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Context: Omega-3 fatty acids have been recently proposed to induce neural improvement in patients with spinal cord injury (SCI) while affecting some hormones including leptin and adiponectin. Objectives: We tried to evaluate the effect of omega-3 fatty acids on circulatory concentrations of leptin and adiponectin among these patients. Design: This study is a double-blinded randomized clinical trial with intervention duration of 14 months. Setting: A tertiary rehabilitation center. Participants: Total of 104 patients with SCI who did not meet our exclusion criteria entered the study. Those with history of diabetes, cancer, endocrinology disease, acute infection, and use of special medications were excluded. Patients were divided randomly into the treatment and control group by using permuted balanced block randomization. Intervention: The treatment group received two MorDHA ® capsules per day (each capsule contain 465 mg of docosahexaenoic acid (DHA) and 63 mg of eicosapentaenoic acid (EPA)) for 14 months while the control group received placebo capsules with similar color, shape, and taste. Main outcomes measures: Leptin and adiponectin concentrations in plasma were measured at the beginning of trial and then after 6 and 14 months. Results: Fourteen months of treatment with DHA and EPA did not influence concentrations of leptin but adiponectin level was significantly decreased (P: 0.03). Weight was positively correlated with leptin level at stage 0 of trial (P: 0.008, r = 0.41) while this association was attenuated through stages of trial after intervention. Conclusion: Our data show that omega-3 fatty acids may not affect plasma concentrations of leptin but adiponectin level is decreased in patients with SCI. Moreover, this intervention influences the linear relationship between weight and leptin after 14 months administration of DHA and EPA.

show abstract

Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis

Cited by 18 publications

References 22 publications

Incomplete Spinal Cord Injury Reverses the Level-Dependence of Spinal Cord Injury Immune Deficiency Syndrome

Incomplete Spinal Cord Injury Reverses the Level-Dependence of Spinal Cord Injury Immune Deficiency Syndrome

Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study

Omega-3 fatty acids’ effect on leptin and adiponectin concentrations in patients with spinal cord injury: A double-blinded randomized clinical trial

Contact Info

Product

Resources

About