Circulating Irisin Concentrations in Rat Models of Thyroid Dysfunction — Effect of Exercise

Samy, Doaa M.; Ismail, Cherine A.; Nassra, Rasha A.

doi:10.1016/j.metabol.2015.01.001

Cited by 80 publications

(73 citation statements)

References 52 publications

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“…The preliminary study by Ruchala et al [17] states that changes in thyrometabolic state may alter serum irisin level. However, the results obtained by Samy et al [18], who described serum irisin concentration in rats with short-term drug-induced hyperand hypothyroidism, were not fully consistent with the previous clinical study. Therefore, the aim of the present research is to evaluate the changes in serum irisin level in long-lasting autoimmune hypothyroidism, short-term hypothyroidism in athyreotic patients after L-thyroxine treatment withdrawal before radioiodine therapy, and a control group with no impairment of thyroid function.…”

Section: Discussioncontrasting

confidence: 59%

“…It indicated that the irisin concentrations may vary according to the thyrometabolic state, and it may be related to the degree of muscle damage, presented by elevated CK level. Recently, Samy et al [18] reported the up-regulation of serum irisin in male rats with hyper-and hypothyroidism, which may be associated with oxidative damage and/or myopathy observed in both conditions. In the described study, the drug-induced thyroid impairment lasted for only three weeks.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, irisin probably has no in vitro effect on cell proliferation and malignant potential of thyroid cancer cell lines [25]. According to Samy et al [18], the irisin level may be even transiently elevated after the induction of hypothyroidism due to reported muscle damage and leaks from damaged muscle cells. Disturbance or disintegration of striated muscle tissue with concomitant leakage…”

Section: Discussionmentioning

confidence: 99%

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Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

Zybek-Kocik¹,

Sawicka‐Gutaj²,

Wrotkowska³

et al. 2016

Endokrynologia Polska

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Introduction: Irisin, a cleaved and secreted part of the transmembrane protein FNDC5, is a recently discovered adipo-myokine that is said to have a significant influence on body metabolism. Changes in thyrometabolic state may also alter the serum irisin level. Since already reported data are not fully consistent, the aim of the present research is to evaluate the time-dependent changes in serum irisin level in patients affected by overt hypothyroidism. Material and methods:The study involved 36 subjects -two groups of 12 patients with long-lasting (AITD) and short-term (TC) overt hypothyroidism, and a control group (CG) of 12 subjects, matched for age and gender. Serum irisin level, thyrometabolic state, creatine kinase (CK -muscle damage marker), glucose, and insulin concentration were assessed and compared between groups. Results: The irisin level was significantly lower in AITD than in TC and CG (p = 0.02; p < 0.01; respectively) patients, with no statistical difference between TC and CG (p > 0.05). There was no significant difference between free triiodothyronine and free thyroxine levels in AITD and TC patients (p > 0.05). CK concentration was significantly higher in AITD than in CG patients (p < 0.01) with no difference between AITD and TC patients (p > 0.05) as well as TC and CG patients (p > 0.05). Additionally, the CK level negatively correlated with the irisin level (r = -0.58; p < 0.01).

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

Zybek-Kocik¹,

Sawicka‐Gutaj²,

Wrotkowska³

et al. 2016

Endokrynologia Polska

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“…It was suggested that during muscular exercise, peroxisome proliferator-activated receptor-gamma (PPAR-γ) coactivator-1 α (PGC1 α) expression is increased in the muscle [3]. This induces the expression of fibronectin type-III domaincontaining 5 (FNDC5), which is then cleaved and secreted as irisin (14). This can trigger energy hemostasis and metabolism, improve obesity and glucose intolerance, which is why it is known as a beneficial factor in recovering from disease (2).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Rashidlamir

Hoseinzadeh

Dashtkhaki

2017

Ann. Appl. Sport Sci

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Background. The accumulation of excess triglyceride in the liver and a decrease in brown adipose tissue is related to the fatty liver disease. Regular physical activity can take part in regulating fat oxidation and inhibiting fat accumulation by creating and releasing some myokines. Nevertheless, the effectiveness of each training method in this regard is still not certain. Objective(s). This study aims at comparing the effects of resistance and endurance training on FNDC5 (the precursor of irisin myokine) gene expression in male rat liver tissues.. Methods. Fifteen Wistar male rats (aged 10-12 weeks with an average weight of 331.8 ±63.09 gr) were used. After being taken to the animals' laboratory, the subjects were randomly assigned to three equal groups viz: control (N=5), endurance (N=5) and resistance (N=5). For the purpose of tissue sampling, all these subjects were anesthetized 72 hours after the experiment had been completed. The liver tissue was immediately removed and then quickly frozen in liquid nitrogen and kept at a temperature of -80o C until RNA extraction. FNDC5 relative gene expression was identified by Real-time PCR method. Results. Data analysis revealed a significant difference in FNDC5 gene expression among the groups (P=0.008, Chi Square=31.791). No significant difference was observed between the resistance training and endurance training groups in FNDC5 gene expression, though (P=0.959). Conclusion. It can be established that both resistance and endurance training can similarly affect the production and secretion of exerciseinduced myokines, including FNDC5 irisin, which can in turn protect against obesity and its impacts on the liver tissue by stimulating the process of browning of white fat.

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“…2016;60/2 creatine kinase (CK) levels were observed. The authors concluded that the muscle oxidative stress present in both conditions could possibly be responsible for these results (9), which were corroborated by increased irisin levels in statin-treated patients (10). Acute exercise elevated irisin levels in all groups of thyroid dysfunction rats, although chronic training exercise did not, which provides consistency to the notion that irisin might possibly be secreted as a result of muscle acute stress, decreasing the likelihood of being a major factor of the eumetabolic status of physically active patients (11).…”

mentioning

confidence: 97%

Elevated irisin and alanine aminotransferase levels in hypothyroidism: role of oxidative stress?

Halpern

2016

Arch. Endocrinol. Metab.

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I n this issue of Archives of Endocrinology and Metabolism, two articles help to increase our knowledge about the connections between thyroid status and energy metabolism. Although the relation between thyroid disease with obesity and metabolic dysfunction has been well established for many decades, some of their linking mechanisms are surprisingly still poorly understood.In the first paper, a cross-sectional observational study, Ates and cols.(1) measured irisin levels of 37 patients with newly diagnosed hypothyroidism (and a mean TSH of 13.1 mIU/L) and 37 healthy volunteers.Irisin is a recently identified proliferator-activated receptor-gamma coactivator-1α (PGC-1α)-dependent myokine that drives browning of white fat via elevation of uncoupling protein-1 (UCP-1), leading to thermogenesis and metabolic improvement (2). It was demonstrated to be a cleavage product of the extracellular portion of type I membrane protein fibronectin type III domain containing 5 (FNDC5), that is released after physical activity. The isolation of irisin in 2012 led to a great rush in understanding its function and metabolic relevance, as it was initially considered one of the main drivers of the beneficial effects of exercise (2,3). However, its impact was weakened by further studies that questioned the metabolic relevance of irisin in humans since there is a substantial controversy whether humans are able to cleave the protein FNDC5 (4,5). This would happen due to humans have a truncated form of FNDC5 gene, and as a result, irisin levels be insignificant, and its detection in serum would be due to analytical interferences. Even though this theory is up to this time a matter of debate, many publications about irisin have arisen in the last years, both in animals and humans.Another disappointment about the potential role of irisin in metabolic improvement (and maybe as a potential therapeutic agent) was the observation that obese individuals and patients with metabolic syndrome have higher levels of irisin and that weight loss (regardless of whether through caloric restriction or bariatric surgery) leads to a decrease in irisin levels (6-8). Could this phenomenon be due to an "irisin resistance" analogous to insulin or leptin resistance or it could be due to a defense against metabolic impairment? These are questions still unanswered, and the first study in this journal issue points in the same controversial direction, demonstrating higher levels of irisin in hypothyroid patients (1). In the study, the mean BMI was not statistically different between groups (27.77 vs 26.11 kg/m 2 , in hypothyroid and control groups, respectively) and the main parameters associated with irisin levels were age, TSH and free T4 levels. On one hand, these results are in agreement with a study in a murine model of thyroid dysfunction, in which an upregulation of irisin levels in both hyper and hypothyroid rats, as well as a positive correlation between irisin and

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Circulating Irisin Concentrations in Rat Models of Thyroid Dysfunction — Effect of Exercise

Cited by 80 publications

References 52 publications

Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

The Effects of Resistance and Endurance Training on the Liver Tissue FNDC5 mRNA Gene Expression in Male Rats

Elevated irisin and alanine aminotransferase levels in hypothyroidism: role of oxidative stress?

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