Circulating Immune Complexes in Erythema Nodosum and Early Sarcoidosis

Jones, J. Verrier; Gumming, R.; Asplin, C. M.; László, G.; Wh, Robertson

doi:10.1016/s0140-6736(76)93204-9

Cited by 13 publications

(3 citation statements)

References 10 publications

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“…It has been considered that EN is the result of a nonspecific cutaneous reaction to various antigens, so the mechanism involved would be immune-mediated [8]. Based on this, it has been suggested that it may be the result of the formation of immune complexes and their deposition around the septa vessels of the connective tissue of the subcutaneous cellular tissue, and it has been possible to demonstrate the presence of circulating immunocomplexes and activation of the complement [9]. Additionally, histopathological features and numerous direct and indirect tests support the idea of a delayed type IV hypersensitivity response to many antigens.…”

Section: Discussionmentioning

confidence: 99%

“…Acetylsalicylic acid, Sulfonamides, Penicillins, Oral contraceptives and Inhibitors of Tumor Necrosis Factor alpha (TNF α) have been implicated. Well-documented cases are extremely rare so a recurrent presentation in relation to intake can be an element of guidance [9]. Some neoplastic processes have been related to the production of the same, highlighting the leukemias, and within them the acute myeloid variety; and lymphomas, being more frequent in Hodking lymphomas.…”

Section: Discussionmentioning

confidence: 99%

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Sarcoidosis presenting as erythema nodosum

Valenzuela¹,

Concha²,

Barros³

2018

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Introduction: Nodular lesions and painful, symmetrical, erythematous plaques located predominantly on the extensor surfaces of the lower limbs, meaning that an appropriate clinical analysis should be performed, since it involves a wide range of causes. Case Report: We present a case report of a 25-year-old male patient diagnosed with sarcoidosis. His first clinical manifestation was the appearance of lesions compatible with erythema nodosum, accompanied by polyarthralgias of inflammatory characteristics predominantly in the lower limbs. The presence of noncaseating granulomas is demonstrated in taken biopsies. Erythema nodosum is an acute septal panniculitis of subcutaneous fat without signs of true vasculitis, and is the most common clinical-pathological variety of panniculitis. Being a reactive cutaneous process, it can be triggered by a long list of infectious, inflammatory disorders, malignant neoplasms and medications. Conclusion: Erythema nodosum is usually benign, its approach requires a practice that focuses on the determination of concomitant pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sarcoidosis presenting as erythema nodosum

Valenzuela¹,

Concha²,

Barros³

2018

Int J Case Rep Images

View full text Add to dashboard Cite

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“…Accompanying systemic symptoms such as fever, malaise and arthralgias may also be present [179]. Although it has been suggested that EN is a circulating immune complexmediated process, the potential pathogenic role of circulating immune complexes is not clear [180]. The histopathology of EN shows a neutrophilic perivascular reaction with septal panniculitis in the deep dermis and subcutaneous tissue, the epidermis appearing normal.…”

Section: Other Agentsmentioning

confidence: 99%