Chronische Gelenkentzündungen

Mohr, W.

doi:10.1007/978-3-642-57071-1_12

Cited by 6 publications

(11 citation statements)

References 654 publications

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“…The explicit extra-articular manifestation of A-SV, and extensive involvement of the cardiovascular, respiratory, urinary, and alimentary system in RA [14][15][16], or SSc [17][18][19] support and explain our data of mortality caused by A-SV of autoimmune origin.…”

Section: Discussionsupporting

confidence: 54%

Complications and Mortality in Systemic Vasculitis – Vasculogenic Clinicopathologic Entities in Rheumatoid Arthritis and Progressive Systemic Sclerosis Autopsy Patients

Bély¹,

Apáthy²

2017

J Vasc

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Section: Discussionsupporting

confidence: 54%

Complications and Mortality in Systemic Vasculitis – Vasculogenic Clinicopathologic Entities in Rheumatoid Arthritis and Progressive Systemic Sclerosis Autopsy Patients

Bély¹,

Apáthy²

2017

J Vasc

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“…There are excellent descriptions about the morphology of vasculitis and vascular changes in SSc [24][25][26][27], but these do not mention the prevalence in percent, neither in various organs, nor in mortality. Most of the autopsy studies focus on organ involvement only [26,27,28].…”

Section: Prevalence and Nature Of Sv In Sscmentioning

confidence: 99%

“…The high prevalence of vasculitis in the kidneys (with complex nephropathy), in the heart (with consecutive endo-myocardial fibrosis or myocardiocytolysis), in the lungs (with interstitial, and "honeycomb" fibrosis), and in the gastrointestinal tract (with consecutive submucosal fibrosis) [26][27][28] correlate with the characteristic cardiac, pulmonary, renal and gastrointestinal clinical signs of SSc patients, and remind us to carefully evaluate the symptoms of these [29][30][31]. The SSc patients died of uremia caused by complex nephropathy, or heart failure due to endo-myocardial fibrosis or myocardio cytolysis with or without honeycomb lung.…”

Section: Prevalence and Nature Of Sv In Sscmentioning

confidence: 99%

Systemic Vasculitis in Various Organs of 33 Rheumatoid Arthritis and 11 Progressive Systemic Sclerosis Patients – A Comparative Postmortem Study

Bély¹,

Apáthy²

2015

JCTCD

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“…Numerous early and recent studies discuss the relationship between gU or dU and non-steroidal antiinflammatory drugs [2][3][4][5], corticosteroids [4][5][6][7][8], anticoagulants [6], with or without other contributing common factors (sex, age, smoking, alcohol consumption, etc. ).The therapy induced peptic ulcers (with complications like perforations, peritonitis, septic infections or bleeding) play an important role in the mortality of RA [9,10]. Gastrointestinal involvement by complications of RA, such as systemic vasculitis or amyloidosis -with or without peptic ulcers -is also well known [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…).The therapy induced peptic ulcers (with complications like perforations, peritonitis, septic infections or bleeding) play an important role in the mortality of RA [9,10]. Gastrointestinal involvement by complications of RA, such as systemic vasculitis or amyloidosis -with or without peptic ulcers -is also well known [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

GHOA

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SummaryAim: The aim of this study was to determine the prevalence and mortality of gastric (gU) and duodenal (dU) peptic ulcers in rheumatoid arthritis (RA). Also, to evaluate the possible relationship between gU and dU and autoimmune vasculitis (A-SV), AA amyloidosis (AAa) or lethal septic infection (SI) with or without purulent arthritis (PA). Patients and Methods:A randomized autopsy population of 234 in-patients with RA was studied. RA was confirmed clinically according to the criteria of the ACR.The presence of gU and dU, A-SV, AAa, SI, or PA was determined at autopsy and supported by histological examination. The relationships between prevalence and mortality of gU or dU and A-SV, AAa, SI or PA were analyzed by Pearson's chi-squared (χ 2 ) test.Results and Conclusions: gU was found in 11 (4.70%), dU in 9 (3.85%), A-SV in 47 (20.08%), AAa in 48 (20.51%), and SI in 31 (13.24%), accompanied with PA in 15 (6.41%) of 234 patients. The negative correlation between A-SV, AAa, or PA and prevalence of gU or dU suggests that -in our autopsy population -A-SV, AAa or PA had no pathogenic role in development of gastric or duodenal ulcers. A-SV, AAa or PA not influenced the mortality of gU or dU. Gastric or duodenal ulcers can be regarded as associated diseases of RA and not as complications of it. The significant connection between SI and prevalence and mortality of gU or dU indicates a causal relationship between them: the development of gU or dUs increase the risk of lethal SI. The aim of this study was to determine the prevalence and mortality of gU and dU in RA. Also, to identify the possible role of systemic autoimmune vasculitis (A-SV) or AA amyloidosis (AAa) in the prevalence and mortality of gU and dU, furthermore to evaluate the possible relationship between gU and dU and lethal septic infection (SI) with or without purulent arthritis (PA). The basic disease, its complication(s), and the lethal outcome caused by gU and dU were determined and analyzed retrospectively, reviewing the clinical and pathological reports. The presence of gU or dU and A-SV, AAa furthermore SI (with or without PA) was determined at autopsy and confirmed by a detailed review of extensive histological material. From each patient 50-100 tissue blocks of 12 organs (heart, lung, liver, spleen, kidneys, pancreas, gastrointestinal tract, adrenal glands, skeletal muscle, peripheral nerve, skin and brain) were studied microscopically [13]. Keywords: Patients and Methods Prevalence and Mortality of Gastric and Duodenal Ulcers in Rheumatoid Arthritis -A Retrospective Clinicopathologic Study of 234 Autopsy Patients 2/9Copyright: ©2017 Bély et al. Results gU was found in 11 (4.70%), and dU in 9 (3.85%) of 234 RA patients (Figure 1.1). Seven gU of 11, and 6 dU of 9 led to death in 13 (65.0 %) of 20 patients (Figure 1.2). In 4 patients (in 2 with gU and in 2 with dU) the direct cause of death was massive internal bleeding, and in 3 (in 2 with gU and in 1 with dU) it was perforation of an ulcer accompanied by peritonitis. Perforated gU (n=3 of 11) an...

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Chronische Gelenkentzündungen

Cited by 6 publications

References 654 publications

Complications and Mortality in Systemic Vasculitis – Vasculogenic Clinicopathologic Entities in Rheumatoid Arthritis and Progressive Systemic Sclerosis Autopsy Patients

Complications and Mortality in Systemic Vasculitis – Vasculogenic Clinicopathologic Entities in Rheumatoid Arthritis and Progressive Systemic Sclerosis Autopsy Patients

Systemic Vasculitis in Various Organs of 33 Rheumatoid Arthritis and 11 Progressive Systemic Sclerosis Patients – A Comparative Postmortem Study

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