Circulating Glucose-Regulated Protein 78 Levels in Patients with Chronic Hepatitis B Infection

Cırrık, Selma; Çetinkol, Yeliz; Yıldırım, Arzu Altunçekiç; Calgin, Mustafa Kerem; Noyan, Tevfik

doi:10.4274/vhd.2018.0011

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…In a recent study, it was revealed that GRP78 overexpression inhibited synoviocyte apoptosis in the synovial fluid samples of patients with rheumatoid arthritis, which is known as a chronic inflammatory process, and synovicyte proliferation and angiogenesis were found to increase in rats with osteoarthritis with repeated intra-articular BIX (32). In a study conducted on chronic viral hepatitis B patients, no statistically significant differences were found in GRP78 levels examined in peripheral blood samples of the patient and healthy groups (35). Moreover, Ardic et al have examined the prognostic value of ER stress markers in patients who were admitted to emergency service with cardiac arrest, and demonstrated that GRP78 concentrations did not have an impact on ROSC, 24-h, and 1-to 3-month survival periods.…”

Section: Discussionmentioning

confidence: 98%

Predictive Value of Endoplasmic Reticulum Stress Markers in Low Ejection Fractional Heart Failure

Sabırlı

Köseler

Mansur

et al. 2019

In Vivo

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Background/Aim: Endoplasmic reticulum (ER) stress plays a critical role in the development of cardiac hypertrophy and heart failure. Heart failure is a crucial health problem that affects 23 million people worldwide, causes approximately 2.4 million people to be hospitalized every year in the USA, and leads to the death of more than 300,000 people. In this study, we aimed to investigate the clinical significance of ER stress markers and the predictive value of acute decompensated heart failure in patients with low ejection fraction heart failure (ADHF). Patients and Methods: This is a prospective case control study. The data included laboratory parameters pertaining to patients with ADHF in the emergency service and lipid parameters obtained during their admission to the hospital. In addition, the same parameters obtained from the control group patients with chronic heart failure (CHF) during their routine polyclinic control were recorded in the data set. Admission time to the hospital and length of hospital stay were included in the data. The levels of glucose regulated protein (GRP78), protein kinase RNA-like endoplasmic reticulum kinase (PERK), and C/EBP homologous protein (CHOP) in peripheral blood serum obtained from the patients and the control group were measured using the ELISA method. Results: Serum GRP78 concentration was lower in the HF group (p=0.003) compared to the control. The median value of serum PERK concentration in the HF group was higher than that of the control group (573 pg/ml, IQR=477.5-650 vs. 495.5 pg/ml, IQR=294-648, respectively) (p=0.001). However, there were no statistically significant differences in GRP78 and PERK serum concentrations between ADHF and CHF subgroups. Receiver operating characteristic (ROC) curve analysis showed greater area under the curve (AUC) for the serum GRP78 levels of the healthy individuals (AUC=0.748, 95% CI=0. 681-0.814, p=0.0003). The serum GRP78 level was found to be 80% sensitive and 70% specific at 147.5 pg/ml (p=0.0003) for distinguishing healthy individuals from HF patients. In the ADHF subgroup, there was a moderate correlation between hospitalization time and serum CHOP concentrations (Spearman rho=0.586 and p=0.001). Conclusion: High GRP78 serum concentration may protect the patient from ER stress. In addition, the serum PERK level is high in patients with HF, whereas it is insufficient in predicting acute decompensation. CHOP may be useful in predicting the length of hospital stay in patients with ADHF.Heart failure (HF) is a clinical syndrome caused by the structural or functional impairment of ventricular filling or the ejection of blood. There is no single diagnostic test for HF, because it is a clinical diagnosis largely based on a history and physical examination of patients. HF is divided into two main groups based on the status of ejection fraction (EF) in the 2013 ACCF/AHA Heart Failure Guidelines: EFpreserved HF (HFpEF) and HF with low EF (HfrEF), EF>50

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Section: Discussionmentioning

confidence: 98%

Predictive Value of Endoplasmic Reticulum Stress Markers in Low Ejection Fractional Heart Failure

Sabırlı

Köseler

Mansur

et al. 2019

In Vivo

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“…GRP78, one of the ER stress markers previously studied in conditions such as heart failure [ 24 ], cardiac arrest [ 25 ], hepatitis infection [ 26 ], is known to play a key role, especially in coronavirus infections. Previous research has documented that, when ER stress occurs in viral infections, GRP78 is overexpressed and translocated from the ER to the cell membrane, and that it is also involved in the internalization of numerous viruses, such as Bat Coronavirus, MERS-CoV, Ebola Virus, Dengue Virus, Japanese Encephalitis Virus, Influenza Virus, and Zika Virus, to the host cell.…”

Section: Discussionmentioning

confidence: 99%

High GRP78 levels in Covid-19 infection: A case-control study

et al. 2021

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“…As GRP78 is upregulated during ER stress, it is considered as an indicator for ER stress both in tissue and blood. Circulatory GRP78 level was measured in a limited number of studies and no study was related to neurodegenerative/psychiatric disease (20)(21)(22). Nevertheless, obesity, which is a hepatic ER stress condition, was reported to induce a GRP78 elevation in plasma as well as in the liver (20).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of plasma GRP78 levels in patients with autism spectrum disorder

Cırrık¹

2021

Dusunen Adam

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Objective: The role of endoplasmic reticulum (ER) stress in the pathogenesis of autism spectrum disorder (ASD) has been previously reported in both experimental and postmortem studies. However, no circulating marker of ER stress has been identified so far in ASD patients. In the present study, the plasma level of glucose-regulated protein 78 (GRP78) was investigated in ASD patients as a potential marker for ER stress.Method: Plasma samples taken from healthy control subjects (n=26) and ASD patients (n=29) were used to evaluate circulating GRP78 levels. Plasma GRP78 concentrations were measured by ELISA. The severity of the disease in the ASD group was determined by the childhood autism rating scale.Results: There was no significant difference between the median values of plasma GRP78 levels in ASD (12.40) and healthy control groups (11.11) (p<0.218). Plasma GRP78 concentration was 12.81±4.90 ng/mL in the ASD group and was not significantly different from the control values (11.12±3.83 ng/mL). Conclusion:Although ER stress was associated with ASD, our results showed that plasma levels of GRP78 did not change in ASD patients. Our results suggest that GRP78 is not an appropriate circulatory marker to evaluate ER stress in ASD patients.

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Circulating Glucose-Regulated Protein 78 Levels in Patients with Chronic Hepatitis B Infection

Cited by 4 publications

References 28 publications

Predictive Value of Endoplasmic Reticulum Stress Markers in Low Ejection Fractional Heart Failure

Predictive Value of Endoplasmic Reticulum Stress Markers in Low Ejection Fractional Heart Failure

High GRP78 levels in Covid-19 infection: A case-control study

Evaluation of plasma GRP78 levels in patients with autism spectrum disorder

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