Circulating filarial antigen in the hydrocele fluid from individuals living in a bancroftian filariasis area - Recife, Brazil: detected by the monoclonal antibody Og4C3-assay

“…This test, however, fails to detect Brugia malayi infection. For this, another test called the sandwich ELISA detects antibodies to the recombinant antigen Bm-SXP-1 is used [5].…”

Section: Discussionmentioning

confidence: 99%

A Case of Tropical Eosinophilia in a Foreign Worker in Singapore

et al. 2018

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Tropical pulmonary eosinophilia (TPE) is a rare, but well recognized syndrome characterized by pulmonary interstitial infiltrates and marked peripheral eosinophilia. Early recognition and treatment with the antifilarial drug, diethylcarbamazine, is important, as delay before treatment may lead to progressive interstitial fibrosis and irreversible impairment. Here, we present a case of patient who presented with respiratory tract symptoms and marked eosinophilia. He was diagnosed with TPE from filariasis and was treated with antifilarial medications, leading to a full recovery.

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“…Several studies have shown that the sensitivity of both parasitological and antigen tests decreases as the MF loads decrease 21,31,33,41 . This decrease may result in differential performance across population subgroups.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of diagnostic tests for Wuchereria bancrofti infection in Brazilian schoolchildren

Oliveira

Braga

Alexander

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Introduction:Since the launch of the Global Programme to Eliminate Lymphatic Filariasis, more than 70% of the endemic countries have implemented mass drug administration (MDA) to interrupt disease transmission. The monitoring of fi larial infection in sentinel populations, particularly schoolchildren, is recommended to assess the impact of MDA. A key issue is choosing the appropriate tools for these initial assessments (to defi ne the best intervention) and for monitoring transmission. Methods: This study compared the pre-MDA performance of fi ve diagnostic methods, namely, thick fi lm test, Knott's technique, fi ltration, Og4C3-ELISA, and the AD12-ICT card test, in schoolchildren from Brazil. Venous and capillary blood samples were collected between 11 pm and 1 am. The microfi larial loads were analyzed with a negative binomial regression, and the prevalence and associated 95% confi dence intervals were estimated for all methods. The accuracies of the AD12-ICT card and Og4C3-ELISA tests were assessed against the combination of parasitological test results. Results: A total of 805 schoolchildren were examined. The overall and stratifi ed prevalence by age group and gender detected by Og4C3-ELISA and AD12-ICT were markedly higher than the prevalence estimated by the parasitological methods. The sensitivity of the AD12-ICT card and Og4C3-ELISA tests was approximately 100%, and the positive likelihood ratios were above 6. The specifi city of the Og4C3-ELISA was higher than that of the AD12-ICT at different prevalence levels. Conclusions: The ICT card test should be the recommended tool for monitoring school-age populations living in areas with ongoing or completed MDA.

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Circulating filarial antigen in the hydrocele fluid from individuals living in a bancroftian filariasis area - Recife, Brazil: detected by the monoclonal antibody Og4C3-assay

Abstract: The purpose of this study was to examine the circulating filarial antigen (CFA)

Cited by 19 publications

References 21 publications

Comparison of tests for the detection of circulating filarial antigen (Og4C3-ELISA and AD12-ICT) and ultrasound in diagnosis of lymphatic filariasis in individuals with microfilariae

Comparison of tests for the detection of circulating filarial antigen (Og4C3-ELISA and AD12-ICT) and ultrasound in diagnosis of lymphatic filariasis in individuals with microfilariae

A Case of Tropical Eosinophilia in a Foreign Worker in Singapore

Evaluation of diagnostic tests for Wuchereria bancrofti infection in Brazilian schoolchildren

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