Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides

Meeker, John D.; Ravi, Sarena R.; Barr, Dana Boyd; Hauser, Russ

doi:10.1016/j.reprotox.2007.12.005

Cited by 45 publications

(45 citation statements)

References 48 publications

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“…In humans, chlorpyrifos is proved to be anti-androgenic (Usmani et al 2003;Viswanath et al 2010) and estrogenic (Meeker et al 2008;Ventura et al 2012). It induces alterations in thyroid (Fortenberry et al 2012) and adrenal glands, thereby reducing serum levels of respective hormones.…”

Section: Toxicity On Higher Vertebratesmentioning

confidence: 99%

Chlorpyrifos: pollution and remediation

2015

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The widespread use of pesticides in modern agriculture is of increasing concern due to environmental contamination and subsequent biodiversity loss. Chlorpyrifos is a toxic organophosphate pesticide. Repeated applications of chlorpyrifos modify the soil microbial community structure and pose potential health risks to the other nontargets. Chlorpyrifos has been reported as the second most commonly detected pesticide in food and water. Extensive use of chlorpyrifos in agriculture and persistence in the environment have raised public concern and demand for safe technologies to overcome the pollution and toxicity problems. Here, we review pollution and toxicity issues associated with chlorpyrifos use and discuss strategies to solve pesticide contamination. Chlorpyrifos, previously shown to be resistant to enhanced degradation, has now been proved to undergo enhanced microbe-mediated decay. Here, special emphasis is given to degradation methods such as ozonation, Fenton treatment, photodegradation, and advanced oxidation processes along with microbial degradation. Finally, we focus on degradation process at enzyme and molecular levels which will enable us to elucidate the exact degradative pathway involved in biodegradation.

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Section: Toxicity On Higher Vertebratesmentioning

confidence: 99%

Chlorpyrifos: pollution and remediation

2015

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“…Altered serum reproductive hormone levels have also been reported in epidemiology studies of OP insecticide exposure conducted in men [6,17,18]. For example, serum testosterone (T) levels were inversely related to urinary biomarkers of OP insecticide exposure in cohorts of men from a U.S. fertility clinic [17] and male floriculture workers from Mexico [6].…”

Section: Introductionmentioning

confidence: 99%

Association between urinary biomarkers of exposure to organophosphate insecticides and serum reproductive hormones in men from NHANES 1999–2002

Omoike

Lewis

Meeker

2015

Reproductive Toxicology

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Exposure to organophosphate (OP) insecticides may alter reproductive hormone levels in men and increase the risk for poor reductive health and other adverse health outcomes. However, relevant epidemiology studies in men are limited. We evaluated urinary concentrations of OP metabolites (3,5,6-trichloro-2-pyridinol and six dialkyl phosphates) in relation to serum concentrations of testosterone (T) and estradiol among 356 men aged 20–55 years old from the U.S. National Health and Nutrition Examination Survey. Biomarkers were detected in greater than 50% of the samples, except for diethyldithiophosphate, dimethylphosphate, and dimethyldithiophosphate. In adjusted regression models, we observed a statistically significant inverse relationship between diethyl phosphate (DEP) and T when DEP was modeled as either a continuous or categorical variable. These findings add to the limited evidence that exposure to certain OP insecticides is linked to altered T in men, which may have important implications for male health.

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“…Human exposure to OP insecticides has been most notably associated with detrimental child neurodevelopment (Bouchard et al, 2010; Engell et al, 2011; Fortenberry et al, 2014; Marks et al, 2010). In addition, human exposure to OP insecticides has been linked with a wide variety of other adverse human health effects, including decreased gestational age (Eskenazi et al, 2004; Rauch et al, 2012; Wang et al, 2012), reduced birth weight (Rauch et al, 2012), altered serum hormone concentrations (Meeker et al, 2006a, 2008, 2006b), reduced semen quality (Swan et al, 2013), wheeze (Hopping et al, 2006), and lung cancer (Lee et al, 2004). …”

Section: Introductionmentioning

confidence: 99%

Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women

Lewis

Cantonwine

Toro

et al. 2015

Science of The Total Environment

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Globally, human exposures to organophosphate (OP) insecticides may pose a significant burden to the health of mothers and their developing fetuses. Unfortunately, relevant data is limited in certain areas of the world concerning sources of exposure to OP insecticides in pregnant populations. To begin to address this gap in information for Puerto Rico, we studied repeated measures of urinary concentrations of 10 OP insecticide metabolites among 54 pregnant women from the northern karst region of the island. We also collected demographic data and self-reported information on the consumption of fruits, vegetables, and legumes in the past 48-hr before urine collection and home pest-related issues. We calculated the distributions of the urinary biomarkers and compared them to women of reproductive age from the general U.S. population. We also used statistical models accounting for correlated data to assess within-subject temporal variability of the urinary biomarkers and to identify predictors of exposure. We found that for all but two metabolites (para-nitrophenol [PNP], diethylthiophosphate [DETP]), 50th or 95th percentile urinary concentrations (the metric that was used for comparison was based on the biomarker’s detection frequency) of the other eight metabolites (3,5,6-trichloro-2-pyridinol [TCPY], 2-isopropyl-4-methyl-6-hydroxy-pyrimidine, malathion dicarboxylic acid, diethylphosphate, diethyldithiophosphate, dimethylphosphate, dimethylthiophosphate [DMTP], dimethyldithiophosphate) were somewhat lower in our cohort compared with similarly aged women from the continental United States. TCPY, PNP, DETP, and DMTP, which were the only urinary metabolites detected in greater than 50% of the samples, had poor reproducibility (intraclass correlation coefficient range: 0.19–0.28) during pregnancy. Positive predictors of OP insecticide exposure included: age; marital or employment status; consumption of cherries, grape juice, peanuts, peanut butter, or raisins; and residential application of pesticides. Further research is needed to understand what aspects of the predictors identified influence OP insecticide exposure during pregnancy.

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Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides

Cited by 45 publications

References 48 publications

Chlorpyrifos: pollution and remediation

Chlorpyrifos: pollution and remediation

Association between urinary biomarkers of exposure to organophosphate insecticides and serum reproductive hormones in men from NHANES 1999–2002

Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women

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