Circulating Epstein–Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma

Fellner, Marı́a Dolores; Durand, Karina; Correa, Rita Mariel; Redini, Liliana; Yampolsky, Claudio; Colobraro, Antonio; Sevlever, Gustavo; Teyssié, Angélica R.; Benetucci, Jorge; Picconi, Marı́a Alejandra

doi:10.1016/j.ijid.2006.04.001

Cited by 23 publications

(18 citation statements)

References 40 publications

(56 reference statements)

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“…These results indicated a higher prevalence of EBV infection in HIV infected patients. Fellner et al in 2006 analyzed circulating EBV levels at the different stages of HIV infection and showed that EBV detection was similar in all groups with CD4+ T cell counts higher than 50/mm 3 (P > 0.05), and was significantly higher than in patients with less than 50 CD4+ T cells/mm 3 (P < 0.05) (14).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Epstein-Barr Virus in HIV-Infected Patients, A Case Control Study

Keramat

Basir

Ahmadpour

et al. 2019

J Kermanshah Univ Med Sci

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Background:Patients with AIDS are at risk for contagious infections such as Epstein-Barr virus (EBV) infection. Objectives: The aim of this study was to determine the prevalence of EBV infection in HIV-infected patients and compare it with healthy individuals in Hamadan province in the west of Iran. Methods: In a case-control study, 61 HIV-infected patients and 62 healthy individuals were enrolled. EBV viral capsid antigens (VCA) IgM and IgG antibodies were measured by chemiluminescent immunoassay system and CD4 cell count was measured by flow cytometry. Data were analyzed using SPSS (version 16). Results: All HIV-infected patients (100%) had positive EBV VCA-IgG antibody while 57(91.9%) in the controls were positive (P = 0.02). There was no statistically significant relationship between CD4 cell count and the prevalence of EBV infection in HIV-infected patients (P = 0.4). However, there was a statistically significant relationship between the reduced CD4 cell count and rising EBV VCA-IgG antibody titer (P = 0.001). Moreover, there was no significant association between the prevalence of EBV infection and variables of age, sex and anti-retrovirus therapy in HIV-infected patients (P > 0.05). There was also a significant association between the antibody titer and antiretroviral therapy (P = 0.004). Conclusions:The high prevalence of EBV infection in HIV-infected patients, especially in the patients with a low CD4 count, could lead to high risk of EBV complications.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Epstein-Barr Virus in HIV-Infected Patients, A Case Control Study

Keramat

Basir

Ahmadpour

et al. 2019

J Kermanshah Univ Med Sci

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“…It has been reported that immunocompromised patients have higher baseline viral levels than healthy carriers [99,100] , which decline after treatment. A search for EBV DNA is also useful in patients with EBV-related tumors, except for those with AIDS-related brain tumors in whom the blood levels are low because of the bloodbrain barrier [99,101] . In EBV-related cancers, episomal or naked EBV DNA from apoptotic tumor cells is found 35 February 12, 2012|Volume 1|Issue 1| WJV|www.wjgnet.com in serum and plasma [84,102] , which may also contain tumor cells with latent EBV infection [13] and virions from a small number of tumor cells undergoing lytic infection.…”

Section: Molecular Biologymentioning

confidence: 99%

Serological diagnosis of Epstein-Barr virus infection: Problems and solutions

Paschale

Clerici²

2012

WJV

255

272

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Serological tests for antibodies specific for Epstein-Barr virus (EBV) antigens are frequently used to define infection status and for the differential diagnosis of other pathogens responsible for mononucleosis syndrome. Using only three parameters [viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA)-1 IgG],it is normally possible to distinguish acute from past infection: the presence of VCA IgM and VCA IgG without EBNA-1 IgG indicates acute infection, whereas the presence of VCA IgG and EBNA-1 IgG without VCA IgM is typical of past infection. However, serological findings may sometimes be difficult to interpret as VCA IgG can be present without VCA IgM or EBNA-1 IgG in cases of acute or past infection, or all the three parameters may be detected simultaneously in the case of recent infection or during the course of reactivation. A profile of isolated EBNA-1 IgG may also create some doubts. In order to interpret these patterns correctly, it is necessary to determine IgG avidity, identify anti-EBV IgG and IgM antibodies by immunoblotting, and look for heterophile antibodies, anti-EA (D) antibodies or viral genome using molecular biology methods. These tests make it possible to define the status of the infection and solve any problems that may arise in routine laboratory practice.

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“…Why EBV is so strongly associated with endemic Burkitt's lymphoma but not Burkitt's lymphoma in AIDS patients is not understood. Compared with healthy donors, HIV patients exhibit higher levels of circulating EBV DNA, yet no difference is demonstrated between HIV patients with and without lymphoma [10,11]. Antibody titers to EBV do not appear to correlate with subsequent risk of NHL in HIV patients, but decreases in EBV load with chemotherapy may predict improved outcomes with NHL [10,12].…”

Section: Hiv-associated Lymphomasmentioning

confidence: 99%

Epstein-Barr virus-related lymphoproliferative disorders

Wagner‐Johnston

Ambinder

2007

Curr Hematol Malig Rep

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Esptein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that persists in carriers as a lifelong, mostly asymptomatic infection. EBV is associated with a variety of lymphomas and lymphoproliferative disorders. In this review we provide an update of the relevant literature on EBV-associated lymphoproliferative disorders, with particular emphasis on epidemiology, pathogenesis, and novel treatment approaches.

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Circulating Epstein–Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma

Cited by 23 publications

References 40 publications

Seroprevalence of Epstein-Barr Virus in HIV-Infected Patients, A Case Control Study

Seroprevalence of Epstein-Barr Virus in HIV-Infected Patients, A Case Control Study

Serological diagnosis of Epstein-Barr virus infection: Problems and solutions

Epstein-Barr virus-related lymphoproliferative disorders

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