Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept

Garnero, Patrick; Tabassi, N. Charni-Ben; Voorzanger-Rousselot, Nathalie

doi:10.3899/jrheum.080356

Cited by 67 publications

(50 citation statements)

References 12 publications

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“…Combining both techniques, 26 cases of erosive arthritis (86.7%) were detected. These results are consistent with Wakefield et al, and Brentano et al their study showed that in 40 RA patients US performed on the MCP joints of the dominant hand, detected 6.5-fold more joints with erosions than that detected with X-rays .On other hand, X-rays detected erosion in another 10 (8.8%) patients not detected by US, so combined both techniques revealed 52 (45.6%) patients with erosive diseases [28,29]. So if performing US on a limited number of joints, this reduces the time for examination, it also decreases the capacity to detect erosions.…”

Section: Discussionsupporting

confidence: 89%

Role of Dickkopf-1 and Musculoskeletal Ultrasound in Bone Loss in Rheumatoid Arthritis

Sma¹,

Mg²,

Hf³

et al. 2015

J Med Diagn Meth

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Aiming to study the possible association of Dkk-1 to bone loss detected by MSK ultrasound imaging and DEXA scanning rheumatoid arthritis patients by measuring its serum levels in relation to disease activity and severity. We conducted this study on 30 RA patients and 18 apparently healthy individuals serving as a control group. All patients and controls were subjected to history taking, clinical examination, laboratory investigations, and measurement of serum levels of DKK-1. Assessment of disease activity by using modified DAS 28 score and functional disease activity by MHAQ. Disease severity was assessed by Larsen score and musculoskeletal US to detect erosive arthritis and bone mineral density was assessed by DEXA scanning. Most of RA patients had active disease with mean DAS 28-ESR was 4.96± 1.08 with 26 cases had erosive arthritis (86.7%). serum DKK-1 levels were significantly higher in patients than control group (P<0.001). Serum DKK-1 levels were higher in patients with more severe RA and positively correlated with joints erosions as assessed by Larsen score(r = 0.954, p <0.001) and ultrasound Joint erosions score (p <0.001). Serum Dkk1 in osteoporotic patients was significantly higher than in control group (P˂ 0.001). At serum DKK1 titre (1960pg/dl) it was a reliable diagnostic test of erosions in RA with sensitivity 100%.Conclusion Serum DKK-1 may be a reliable biomarker of erosive arthritis detected by US, bone erosions and osteoporosis in RA. Moreover, it was highly associated with disease activity and severity.

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Section: Discussionsupporting

confidence: 89%

Role of Dickkopf-1 and Musculoskeletal Ultrasound in Bone Loss in Rheumatoid Arthritis

Sma¹,

Mg²,

Hf³

et al. 2015

J Med Diagn Meth

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“…In fact, DKK-1 levels are associated with an increase in the number of articular erosions independently of age, baseline radiological features, C-reactive protein, or disease activity. 33 Systemic bone loss has been correlated with inflammation as well with aging and other inflammatory diseases; the mechanisms are very similar to the ones demonstrated in RA. 1 Figure 1 summarizes the role of T cells in the regulation of osteoclastogenesis in RA.…”

Section: Inflammatory Diseases Immune System and Bonementioning

confidence: 58%

Osteoimmunology: from mice to humans

Sassi¹

2016

Bonekey Reports

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The immune system has been recognized as one of the most important regulators of bone turnover and its deregulation is implicated in several bone diseases such as postmenopausal osteoporosis and inflammatory bone loss; recently it has been suggested that the gut microbiota may influence bone turnover by modulation of the immune system. The study of the relationship between the immune system and bone metabolism is generally indicated under the term 'osteoimmunology'. The vast majority of these studies have been performed in animal models; however, several data have been confirmed in humans as well: this review summarizes recent data on the relationship between the immune system and bone with particular regard to the data confirmed in humans.

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“…Moreover, Dkk-1 expression has been reported to be positively correlated with bone mineral density in bone biopsy specimens of postmenopausal women and also with bone loss in arthritic patients (33,34). Thus, the contribution of Dkk-1 to bone biology in humans remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Sclerostin and Dickkopf-1 in Renal Osteodystrophy

Cejka¹,

Herberth²,

Branscum³

et al. 2011

Clinical Journal of the American Society of Nephrology

223

176

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SummaryBackground and objectives The serum proteins sclerostin and Dickkopf-1 (Dkk-1) are soluble inhibitors of canonical wnt signaling and were recently identified as components of parathyroid hormone (PTH) signal transduction. This study investigated the associations between sclerostin and Dkk-1 with histomorphometric parameters of bone turnover, mineralization, and volume in stage 5 chronic kidney disease patients on dialysis (CKD-5D). Design, setting, participants, & measurementsIn a cross-sectional study, 60 CKD-5D patients underwent bone biopsies followed by histomorphometry. Levels of sclerostin, Dkk-1, and intact PTH (iPTH) were determined in blood.Results Serum levels of sclerostin and iPTH correlated negatively. In unadjusted analyses, sclerostin correlated negatively with histomorphometric parameters of turnover, osteoblastic number, and function. In adjusted analyses, sclerostin remained a strong predictor of parameters of bone turnover and osteoblast number. An observed correlation between sclerostin and cancellous bone volume was lost in regression analyses. Sclerostin was superior to iPTH for the positive prediction of high bone turnover and number of osteoblasts. In contrast, iPTH was superior to sclerostin for the negative prediction for high bone turnover and had similar predictive values than sclerostin for the number of osteoblasts. Serum levels of Dkk-1 did not correlate with iPTH or with any histomorphometric parameter.Conclusions Our data describe a promising role for serum measurements of sclerostin in addition to iPTH in the diagnosis of high bone turnover in CKD-5D patients, whereas measurements of Dkk-1 do not seem to be useful for this purpose.

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Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept

Abstract: Dkk-1 may be an important mediator of bone erosion in patients with RA.

Cited by 67 publications

References 12 publications

Role of Dickkopf-1 and Musculoskeletal Ultrasound in Bone Loss in Rheumatoid Arthritis

Role of Dickkopf-1 and Musculoskeletal Ultrasound in Bone Loss in Rheumatoid Arthritis

Osteoimmunology: from mice to humans

Sclerostin and Dickkopf-1 in Renal Osteodystrophy

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