Circulating Concentrations of Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate During Puberty

Hopper, Bill R.; Yen, S. S. C.

doi:10.1210/jcem-40-3-458

Cited by 157 publications

(50 citation statements)

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“…These results are consistent with those of previous research showing that basal plasma and salivary cortisol levels change only slightly throughout childhood and adolescence, whereas DHEA secretion shows a stronger increase with age (Ducharme et al 1976;de Peretti and Forest 1976;Parker et al 1983). In our study, however, we did not detect the sharp increase in DHEA levels that has been reported to occur in conjunction with adrenarche (Hopper and Yen 1975). Furthermore, although some studies have reported a sex difference in the timing of the increase in DHEA relative to adrenarche, or in overall DHEA concentrations (Ducharme et al 1976; de Peretti and Cortisol (nmol/l) Sample Fig.…”

Section: Discussioncontrasting

confidence: 76%

Day-to-day Variation of Salivary Cortisol and Dehydroepiandrosterone (DHEA) in Children from a Rural Dominican Community

Ponzi

Muehlenbein

Sgoifo

et al. 2014

Adaptive Human Behavior and Physiology

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This study examines day-to-day patterns of salivary cortisol and dehydroepiandrosterone (DHEA) under baseline conditions and in response to mild stress among 59 children residing in a rural Caribbean village. Cortisol secretion showed the typical circadian variation with high levels in the morning. Children showed significant increases of cortisol before and during a videotaped interview when compared to routine days. DHEA levels were positively associated with cortisol levels; however, within-day secretion of salivary DHEA was more stable than cortisol and DHEA levels did not change significantly during the day. Average DHEA concentrations were positively associated with age but did not show the sharp increase that is usually observed at the onset of adrenarche. These results highlight both similarities and differences in the secretion of cortisol and DHEA during childhood among rural and industrialized human populations.

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Section: Discussioncontrasting

confidence: 76%

Day-to-day Variation of Salivary Cortisol and Dehydroepiandrosterone (DHEA) in Children from a Rural Dominican Community

Ponzi

Muehlenbein

Sgoifo

et al. 2014

Adaptive Human Behavior and Physiology

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“…As noted, cholesterol sulfate and DHEA sulfate are two of the most abundant steroid sulfates in the human circulation where their concentrations overlap, although the mean level of the latter sulfoconjugate tends to be somewhat higher (34,(37)(38)(39). There is, however, a remarkable age-dependent decrease in plasma DHEA sulfate from its postpubertal peak (46,47), whereas there appears to be no age-dependent change in the level of plasma cholesterol sulfate (37).…”

Section: Plasma Levelsmentioning

confidence: 94%

Cholesterol sulfate in human physiology: what's it all about?

Strott

Higashi

2003

Journal of Lipid Research

202

184

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Cholesterol sulfate is quantitatively the most important known sterol sulfate in human plasma, where it is present in a concentration that overlaps that of the other abundant circulating steroid sulfate, dehydroepiandrosterone (DHEA) sulfate. Although these sulfolipids have similar production and metabolic clearance rates, they arise from distinct sources and are metabolized by different pathways. While the function of DHEA sulfate remains an enigma, cholesterol sulfate has emerged as an important regulatory molecule. Cholesterol sulfate is a component of cell membranes where it has a stabilizing role, e.g., protecting erythrocytes from osmotic lysis and regulating sperm capacitation. It is present in platelet membranes where it supports platelet adhesion. Cholesterol sulfate can regulate the activity of serine proteases, e.g., those involved in blood clotting, fibrinolysis, and epidermal cell adhesion. As a result of its ability to regulate the activity of selective protein kinase C isoforms and modulate the specificity of phosphatidylinositol 3-kinase, cholesterol sulfate is involved in signal transduction. Cholesterol sulfate functions in keratinocyte differentiation, inducing genes that encode for key components involved in development of the barrier. The accumulating evidence demonstrating a regulatory function for cholesterol sulfate appears solid; the challenge now is to work out the molecular mechanisms whereby this interesting molecule carries out its various roles. -Strott, C. A., and Y. Higashi. Cholesterol sulfate in human physiology: what's it all about? J.

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“…These are two of the adrenal steroids which show a rapid increase during the years before puberty, at adrenarche (Crumbach, Richards, Conte & Kaplan, 1978 ;Ducharme, Forest, DePeretti, Sempe, Collu & Bertrand, 1976;Hopper & Yen, 1975).…”

Section: Males At Pubertymentioning

confidence: 99%

The influence of testosterone on human aggression

Archer

1991

British J of Psychology

477

209

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Animal studies show clear evidence for a causal link between testosterone and aggression. This review assesses studies involving androgens, principally testosterone, and human aggression. Evidence for a possible effect of prenatal androgens is inconclusive. In adults, higher testosterone levels are found in groups selected for high levels of aggressiveness. Correlations between testosterone and aggression were low when hostility inventories were used, but higher (r = .38) when aggressiveness was rated by others. Regression analysis data and studies of boys at puberty were inconclusive. Other studies show that the outcome of aggressive and competitive encounters can alter testosterone levels, thus confounding interpretation of the correlational evidence. The design of future studies to reveal evidence of a causal link is considered. Suggestions concerning two important methodological problems, the experimental manipulation of hormone levels and the nature of the dependent variable, are made.Studies of a wide variety of vertebrate species have indicated that androgens, principally testosterone, facilitate aggressiveness between males, thus providing a mechanism for the increase in male competitive aggression at a time when the animals are reproductively active (Archer, 1988). This ethological evidence raises the question of whether testosterone also facilitates aggression in human males. Some reviews of the human evidence have concluded that it does (Donovan, 1985; Rubin, Reinisch.8~ Haskett, 1981) whereas others have urged caution in drawing this conclusion (Benton, 1983;Carlson, 1986;Rada, Kellner & Winslow, 1976).The purpose of the present paper is to provide a systematic review of current evidence on this issue, to include a limited meta-analysis where possible, and to highlight methodological issues raised by existing studies. The review begins with a brief survey of animal studies to provide a background for the human evidence. The possible involvement of neonatal androgens is then considered briefly, before examining the following types of evidence from adults : comparisons of testosterone levels in selected groups which show high and low levels of aggressiveness; correlations in both selected samples and unselected samples ; and regression analyses. Studies carried out on boys at puberty -when testosterone levels rise dramatically -are then considered. The limitations of correlational evidence are discussed, particularly in relation to the influence of the social environment on testosterone levels. Existing attempts to provide causal analyses are described, before considering how best to design future studies to reveal more clearly whether testosterone facilitates human aggression.

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Circulating Concentrations of Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate During Puberty

Cited by 157 publications

References 0 publications

Day-to-day Variation of Salivary Cortisol and Dehydroepiandrosterone (DHEA) in Children from a Rural Dominican Community

Day-to-day Variation of Salivary Cortisol and Dehydroepiandrosterone (DHEA) in Children from a Rural Dominican Community

Cholesterol sulfate in human physiology: what's it all about?

The influence of testosterone on human aggression

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