Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery disease

Patel, Jeetesh V.; Abraheem, A.; Chackathayil, Julia; Gunning, Mark; Creamer, John; Hughes, Elizabeth; Lip, Gregory Y.H.

doi:10.1111/j.1365-2796.2008.02057.x

Cited by 19 publications

(14 citation statements)

References 26 publications

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“…37 Angiopoietins bind to the endothelial tyrosine kinase receptor Tie-2 to exert context-dependent biological functions, 37 and circulating levels of Ang-2 and Tie-2 have been associated with CVD risk factors (e.g., hypertension, diabetes mellitus, and abdominal obesity). 38 Ang-2 has previously been found to have a positive association with PP. 37 Our study did not find an association between PP and Ang-2; however, we found a positive association between PP and Tie-2.…”

Section: Discussionmentioning

confidence: 90%

Elevated Markers of Vascular Remodeling and Arterial Stiffness Are Associated With Neurocognitive Function in Older HIV+ Adults on Suppressive Antiretroviral Therapy

Montoya

Iudicello²,

Fazeli³

et al. 2017

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background HIV is associated with elevated markers of vascular remodeling that may contribute to arterial fibrosis and stiffening, and changes in pulse pressure (PP). These changes may, in turn, deleteriously affect autoregulation of cerebral blood flow and neurocognitive function. Methods To evaluate these mechanisms, we studied markers of vascular remodeling, PP, and neurocognitive function among older (≥50 years of age) HIV-infected (HIV+; n = 72) and HIV-seronegative (HIV-; n = 36) adults. Participants completed standardized neurobehavioral and neuromedical assessments. Neurocognitive functioning was evaluated using a well-validated comprehensive battery. Three plasma biomarkers of vascular remodeling (i.e., angiopoietin 2, Tie-2, and vascular endothelial growth factor; VEGF) were collected. Results HIV+ and HIV- participants had similar levels of plasma Ang-2 (p = .48), Tie-2 (p = .27), VEGF (p = .18), and PP (p = .98). In a multivariable regression model, HIV interacted with Tie-2 (β = .41, p < .01) and VEGF (β = −.43, p = .01) on neurocognitive function, such that lower Tie-2 and higher VEGF values were associated with worse neurocognitive function for HIV+ participants. Greater Tie-2 values were associated with increased PP (r = .31, p < .01). In turn, PP demonstrated a quadratic association with neurocognitive function (β = −.33, p = .01), such that lower and higher, relative to mean sample, PP values were associated with worse neurocognitive function. Conclusions These findings indicate that vascular remodeling and altered cerebral blood flow autoregulation contribute to neurocognitive function. Furthermore, HIV moderates the association between vascular remodeling and neurocognitive function but not the association between PP and neurocognitive function.

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Section: Discussionmentioning

confidence: 90%

Elevated Markers of Vascular Remodeling and Arterial Stiffness Are Associated With Neurocognitive Function in Older HIV+ Adults on Suppressive Antiretroviral Therapy

Montoya

Iudicello²,

Fazeli³

et al. 2017

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Furthermore, level of these biomarkers were associated with measures of subclinical disease13 and target organ damage in hypertension 14. While these preliminary data suggest an important role for angiopoietins along the CVD continuum, the clinical and genetic correlates of Ang-2 and the soluble form of its receptor Tie-2 have not been evaluated in a large community-based sample.…”

Section: Introductionmentioning

confidence: 85%

Clinical and Genetic Correlates of Circulating Angiopoietin-2 and Soluble Tie-2 in the Community

Lieb

Zachariah

Xanthakis

et al. 2010

Circ Cardiovasc Genet

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Background-Experimental studies suggest that endothelial growth factors play an important role in angiogenesis and vascular remodeling. The clinical and genetic correlates of circulating angiopoietin-2 (Ang-2) and its soluble receptor/regulator Tie-2 (sTie-2) have not been determined in a community-based sample. Methods and Results-Serum Ang-2 and sTie-2 were assayed in 3778 third-generation cohort participants of the Framingham Heart Study (mean age, 40Ϯ9 years; 53% women). Clinical correlates and heritability of both biomarkers were assessed using generalized estimating equations and variance-component analyses. Ang-2 levels were higher and sTie-2 levels were lower in women than in men. Ang-2 was positively related to age, smoking, systolic blood pressure, hypertension treatment, and diabetes (PϽ0.05 for all) but was inversely associated with total cholesterol and diastolic blood pressure (PϽ0.0001 for both), and sTie-2 was positively associated with body mass index, diabetes, and triglycerides but was inversely related to age, alcohol consumption, and glomerular filtration rate (PϽ0.05 for all). Both Ang-2 and sTie-2 were higher in participants with metabolic syndrome (PϽ0.005), with stronger associations of Ang-2 with blood pressure traits and of sTie-2 with obesity-dyslipidemia components. Heritability estimates for Ang-2 and sTie-2 were 27% and 56%, respectively (PϽ0.0001). A region on chromosome 9 was significantly linked to circulating sTie-2 levels (logarithm of the odds score, 8.31). Conclusion-Circulating levels of Ang-2 and sTie-2 are heritable traits associated with cardiovascular disease risk factors, including the metabolic syndrome. These observations are consistent with the notion that angiogenesis and vascular remodeling are determined in part by genetic influences and associated with metabolic risk factors. (Circ Cardiovasc Genet. 2010;3:300-306.)

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“…A standard curve of the recombinant Ang-1, Ang-2 or sTie-2 proteins provided was prepared according to the manufacturer's instructions. The kits are widely used in many research groups for detection of Ang-1, Ang-2 or sTie-2 in serum/body fluid/liquid reagents (Iribarren, et al, 2011;Lukasz et al, 2008;Patel et al, 2009;Scholz et al, 2007;Wang et al, 2007). In the current study, the detection limit for Ang-1 was 180 pg/mL, 125 pg/mL for Ang-2 and 320 pg/mL for sTie-2.…”

Section: Subjects and Sample Collectionmentioning

confidence: 92%

Source of angiopoietin-2 in the sera of women during pregnancy

Woolnough

Wang

Kan

et al. 2012

Microvascular Research

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Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery disease

Cited by 19 publications

References 26 publications

Elevated Markers of Vascular Remodeling and Arterial Stiffness Are Associated With Neurocognitive Function in Older HIV+ Adults on Suppressive Antiretroviral Therapy

Elevated Markers of Vascular Remodeling and Arterial Stiffness Are Associated With Neurocognitive Function in Older HIV+ Adults on Suppressive Antiretroviral Therapy

Clinical and Genetic Correlates of Circulating Angiopoietin-2 and Soluble Tie-2 in the Community

Source of angiopoietin-2 in the sera of women during pregnancy

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