Source of angiopoietin-2 in the sera of women during pregnancy

Woolnough, C.; Wang, Y.; Kan, Chi‐Fai; Morris, Jonathan M.; Tasevski, Vitomir; Ashton, Anthony W.

doi:10.1016/j.mvr.2012.08.003

Cited by 10 publications

(9 citation statements)

References 44 publications

(54 reference statements)

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“…In contrast, the present study's results on ADAM-12 levels confirmed previously published data [24], with the FGR group showing a tendency for lower ADAM-12 levels. Furthermore, when we compared the early and late FGR groups, ADAM-12 levels were higher in the late FGR group.…”

Section: Discussionsupporting

confidence: 89%

Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case–control study

Zamarian

Júnior

Daher

et al. 2016

Arch Gynecol Obstet

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Section: Discussionsupporting

confidence: 89%

Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case–control study

Zamarian

Júnior

Daher

et al. 2016

Arch Gynecol Obstet

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“…Our recent data indicated that while the placenta is a key source of Ang-2 during uncomplicated pregnancies it is the decidua that is likely to be the primary source. 21 Release of Ang-2 from the decidua is from both active secretion and new synthesis of Ang-2 protein. 21 We also noted an effect of gestational age on the levels of Ang-2 produced by decidual cells with serum from first trimester inducing greater release than that from third trimester.…”

mentioning

confidence: 99%

“…21 Release of Ang-2 from the decidua is from both active secretion and new synthesis of Ang-2 protein. 21 We also noted an effect of gestational age on the levels of Ang-2 produced by decidual cells with serum from first trimester inducing greater release than that from third trimester. Thus, circulating factors present in early pregnancy, and declining throughout gestation, appear to control Ang-2 release.…”

mentioning

confidence: 99%

“…23 Thus, this might explain the reported up-regulation of Ang-2 early in pregnancy and why it decreases after first trimester. 21 However, preeclampsia is associated with chronic hypoxia, either intermittent or persistent, 24 yet Ang-2 mRNA levels are reduced in preeclamptic placentas. 4 Thus, the raised Ang-1/Ang-2 ratio observed in preeclampsia here may reflect additional aspects of the disease, such as inflammation, which are known to be regulated by Ang-2 levels.…”

mentioning

confidence: 99%

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Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as biomarkers of adverse pregnancy outcomes

Schneuer¹,

Roberts²,

Ashton³

et al. 2014

American Journal of Obstetrics and Gynecology

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Word count:Abstract: 250 Text: 3,183 2 Condensation: Ang-2 and the Ang-1/Ang2 ratio is associated with several adverse pregnancy outcomes but do not predict complications any better than maternal risk factors Short title: Ang-1 and Ang-2 as biomarkers of adverse pregnancy outcomes 3 ABSTRACTObjective: To assess Ang-1, Ang-2 and the Ang-1/Ang-2 ratio levels in the first trimester of pregnancy, their association with adverse pregnancy outcomes; and their predictive accuracy.Study Design: This cohort study measured serum Ang-1 and Ang-2 levels in 4,785 women with singleton pregnancies attending first trimester screening in New South Wales, Australia.Multivariate logistic regression models were used to assess the association and predictive accuracy of serum biomarkers with subsequent adverse pregnancy outcomes (small for gestational age, preterm birth, preeclampsia, miscarriage >10 weeks and stillbirth).Results: Median (interquartile range) levels for Ang-1, Ang-2 and the Ang-1/Ang-2 ratio for the total population were 19.6 ng/ml (13.6-26.4), 15.5 ng/ml (10.3-22.7) and 1.21 (0.83-1.73),respectively. Maternal age, weight, country of birth and socio-economic status significantly affected Ang-1, Ang-2 and the Ang-1/Ang-2 ratio levels. After adjusting for maternal and clinical risk factors, women with low Ang-2 levels (<10 th centile) and high Ang-1/Ang-2 ratio (>90 th centile) had increased risk of developing most adverse pregnancy outcomes.Compared to the Ang-1/Ang-2 ratio alone, maternal and clinical risk factors had better predictive accuracy for most adverse pregnancy outcomes. The exception was miscarriage [Ang-1/Ang-2 ratio area under ROC curve (AUC) =0.70; maternal risk factors AUC =0.58].Overall, adding the Ang-1/Ang-2 ratio to maternal risk factors did not improve the ability of the models to predict adverse pregnancy outcomes. Conclusions:Our findings suggest that the Ang-1/Ang-2 ratio in first trimester is associated with most adverse pregnancy outcomes, but do not predict outcomes any better than clinical and maternal risk factor information.

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“…An important, yet underappreciated family of Angiogenic proteins is that of the Angiopoietin (Ang) family, which has been shown to be critically involved in vasculature development and Angiogenesis, especially in the female reproductive tract [13], [14], [15]. Angs are intimately involved in the process of placental maturation and growth from early pregnancy [16], [17], [18], [19]. Angiopoietin-1 (Ang-1) and Ang-2 are critical regulators with different functions of vascular development and Angiogenesis [20].…”

Section: Introductionmentioning

confidence: 99%

Serum Angiopoietin-2 and β-hCG as Predictors of Prolonged Uterine Bleeding after Medical Abortion in the First Trimester

et al. 2013

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ObjectiveThe combination of mifepristone and misoprostol is an established method for induction of early first trimester abortion, but there is no consensus about the best evaluation of treatment outcome. We evaluate serum Angiopoietin-2(Ang-2) and β human chorionic gonadotropin (β-hCG) in women who had undergone a medical abortion as markers of prolonged uterine bleeding (PUB).MethodsProspective trial involving 2843 women attending an gynecology outpatient clinic who following a medical abortion with mifepristone and misoprostol, the study cohort was divided into women with duration of uterine bleeding >14 days (PUB) and women with duration of uterine bleeding ≤14 days (normal uterine bleeding, NUB). Serum determinations of Ang-2 levels by ELISA and β-hCG levels by electrochemiluminiscence immunoassay. Receiver Operating Characteristics (ROC) analyses were calculated and plotted for the diagnostic accuracy of serum β-hCG and Ang-2 concentration to discriminate PUB and NUB.ResultsBaseline characteristics for both groups were similar, Only duration of bleeding showed a significant difference between the PUB group and NUB group. Ang-2 serum levels moderately correlated with serum β-hCG levels with statistically significant correlation coefficients of 0.536. Serum β-hCG and Ang-2 levels on day 7 and on day 14 after medical abortion were signifcantly higher in PUB group than in NUB group. Plotted as ROC curves, β-hCG area under curve (AUC) was 0.65 (95% CI, 0.53–0.76) on day 7, rising to AUC = 0.83 (95% CI, 0.75–0.92) on day 14. Using Ang-2 on day 7 and day 14 as predictive parameter resulted in an analogous AUC (AUC = 0.61 on day 7, AUC = 0.78 on day 14).ConclusionsBoth parameters are clinically useful as a diagnostic test in predicting PUB after medical abortion, and can be helpful in uncertain clinical situations, but should be considered as supplementary to a general clinical evaluation.

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Source of angiopoietin-2 in the sera of women during pregnancy

Cited by 10 publications

References 44 publications

Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case–control study

Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case–control study

Angiopoietin 1 and 2 serum concentrations in first trimester of pregnancy as biomarkers of adverse pregnancy outcomes

Serum Angiopoietin-2 and β-hCG as Predictors of Prolonged Uterine Bleeding after Medical Abortion in the First Trimester

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