Circulating Antibodies in Sarcoidosis

Immunological Deficiency Disorders Associated with Chronic Lymphocytic Leukemia and Multiple Myeloma*

“…These two deficiency disorders, however, appear to be qualitatively different from those disorders described in association with Hodgkin's disease and sarcoidosis. In the latter diseases, expression of delayed-type hypersensitivity is severely suppressed or absent, but antibody formation may appear normal (28)(29)(30)(31). It is apparent, therefore, that different patterns of immunologic reactivity can be associated with different pathological entities involving the lymphoreticular system.…”

Cortisone and Skin Sensitivity to Tuberculin in Reticuloses

“…Patients with sarcoidosis and reticuloses have been shown to be poor producers of antibody on primary immunization with tetanus toxoid (Greenwood et al, 1958), and it has been suggested that the suppression of tuberculin sensitivity is a manifestation of failure of the normal immunity mechanisms. However, the mechanism for producing humoral antibodies is quite different from that involved in delayed hypersensitivity, for patients with agammaglobulinaemia who cannot form circulating antibodies can be made sensitive to tuberculin by vaccination with B.C.G.…”

Awareness of Family and Contact History of Tuberculosis in Generalized Sarcoidosis

“…It may, for instance, well be that the role of infection with M. tutbercuiilosis is catalytic for an immune process of a highly specific type. Evidence for altered immune reactions in patients with active sarcoidosis has been recorded by Greenwood et al (1958).…”