Circulating adipose tissue proteins involved in atrial fibrillation: An explorative scoping review

Meulendijks, Eva R.; Krul, Sébastien P.J.; Baalman, Sarah W.E.; Vries, Tim A C de; Wesselink, Robin; Ernault, Auriane C.; Kawasaki, Masanori; Al-Shama, Rushd; Neefs, Jolien; Limpens, Jacqueline; Groot, Joris R. de

doi:10.1016/j.tcm.2022.12.004

Cited by 4 publications

(4 citation statements)

References 110 publications

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“…EAT is a unique type of visceral adipose tissue located between the myocardium and visceral pericardium, without an intervening fascial plane 27 . Previous studies revealed that EAT volume is a valuable predictor for the new onset of AF and recurrence of AF following ablation 28 . However, our study revealed that the total EAT volume was not an independent factor for the recurrence of AF.…”

Section: Discussioncontrasting

confidence: 65%

“… 27 Previous studies revealed that EAT volume is a valuable predictor for the new onset of AF and recurrence of AF following ablation. 28 However, our study revealed that the total EAT volume was not an independent factor for the recurrence of AF. Research suggested that the quality of LA adipose tissue, but not total EAT volume is an independent predictor of AF recurrence after ablation.…”

Section: Discussioncontrasting

confidence: 61%

Section: Comparison Of the Predicting Models For Af Recurrencecontrasting

confidence: 61%

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Impact of pericoronary adipose tissue attenuation on recurrence after radiofrequency catheter ablation for atrial fibrillation

Wang

Chen

et al. 2023

Clinical Cardiology

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BackgroundInflammation plays a vital role in the occurrence and progression of atrial fibrillation (AF). The association between pericoronary adipose tissue attenuation (PCATA) and AF recurrence following ablation has not been fully clarified.HypothesisWe aimed to evaluate the association between PCATA and AF recurrence after radiofrequency catheter ablation (RFCA).MethodsPatients who underwent the first RFCA for AF and performed coronary computed tomography angiography before ablation between 2018 and 2021 were enrolled. The predictive values of PCATA for AF recurrence after ablation were investigated. The area under curve (AUC), relative integrated discrimination improvement (IDI), and categorical free net reclassification improvement (NRI) were used to assess the discrimination ability of different models for AF recurrence.ResultsDuring 1‐year follow‐up, 34.1% patients experienced AF recurrence. The multivariable analysis model revealed that PCATA of the right coronary artery (RCA) was an independent risk factor for AF recurrence. Patients with a high level of RCA‐PCATA had a high risk of recurrence, after adjusting for other risk factors by restricted cubic splines. The performance in predicting AF recurrence was significantly improved by adding the marker of RCA‐PCATA to the clinical model (AUC: 0.724 vs. 0.686, p = .024), with a relative IDI of 0.043 (p = .006) and continuous NRI of 0.521 (p < .001).ConclusionsPCATA of RCA was independently associated with AF recurrence after ablation. PCATA may be helpful for risk classification for AF ablation patients.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussioncontrasting

confidence: 61%

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Impact of pericoronary adipose tissue attenuation on recurrence after radiofrequency catheter ablation for atrial fibrillation

Wang

Chen

et al. 2023

Clinical Cardiology

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“…Patients with AF show upregulated inflammatory cytokines, including interleukin‐6, interleukin‐1β, CRP (C‐reactive protein), and tumor necrosis factor (TNF)‐α. 28 , 29 All but interleukin‐1β were also shown to be upregulated in otherwise healthy obese women, suggesting that adipose tissue contributes to systemic inflammation. 30 Inflammatory cytokines were also shown to increase oxidative stress, collagen deposition, and abnormal calcium handling, resulting in tissue damage, local fibrosis, and altered electrophysiology of the atrial tissue.…”

Section: Inflammation Fibrosis and Oxidative Stressmentioning

confidence: 99%

Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options

Sha,

Baines,

Hayes

et al. 2024

JAHA

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Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. Obesity‐driven structural and electrical remodeling contribute to AF via several reported mechanisms, including adiposity, inflammation, fibrosis, oxidative stress, ion channel alterations, and autonomic dysfunction. In particular, expanding epicardial adipose tissue during obesity has been suggested as a key driver of AF via paracrine signaling and direct infiltration. Weight loss has been shown to reverse these changes and reduce AF risk and recurrence after ablation. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited. In this review, we discuss mechanisms by which obesity mediates AF and treatment outcomes, aiming to provide insight into obesity‐drug interactions and guide personalized treatment for this patient subgroup.

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NR4A3 prevents diabetes induced atrial cardiomyopathy by maintaining mitochondrial energy metabolism and reducing oxidative stress

Peng,

Yuan,

Wang

et al. 2024

eBioMedicine

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Circulating adipose tissue proteins involved in atrial fibrillation: An explorative scoping review

Cited by 4 publications

References 110 publications

Impact of pericoronary adipose tissue attenuation on recurrence after radiofrequency catheter ablation for atrial fibrillation

Impact of pericoronary adipose tissue attenuation on recurrence after radiofrequency catheter ablation for atrial fibrillation

Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options

NR4A3 prevents diabetes induced atrial cardiomyopathy by maintaining mitochondrial energy metabolism and reducing oxidative stress

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