Circulating adipocytokines in non‐diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development

Celi, Federica; Bini, Vittorio; Papi, F.; Santilli, E; Castellani, M. S.; Ferretti, Andrea; Mencacci, M.; Berioli, Maria Giulia; Giorgi, G; Falorni, A

doi:10.1111/j.1464-5491.2006.01823.x

Cited by 36 publications

(38 citation statements)

References 47 publications

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“…No significant difference in adiponectin concentrations regarding gender was seen. This observation is confirmed by the paediatric studies where gender differences were not seen either (26,27). In contrast, the published studies in adults report on higher levels of adiponectin in women (12,(23)(24)(25).…”

Section: Discussioncontrasting

confidence: 47%

“…In contrast to adults, studies in children and adolescents with type 1 diabetes show controversial results (26,27). Celi et al reported elevated levels of adiponectin in pre-pubertal children with type 1 diabetes (27). The study by Morales et al revealed that adiponectin levels in children and adolescents with type 1 diabetes did not differ from those in healthy subjects (26).…”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

“…Remarkably, in the present study, adiponectin levels at the time of diagnosis of diabetes were not different from adiponectin levels in control subjects but increased significantly during the follow-up period of the study. Diabetes duration in the two paediatric studies by Celi and Morales varied from 0.6 to 15.9 years and from 0.1 to 10 years respectively (26,27). Duration of diabetes in studies conducted in adults was considerably longer (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…One study showed no differences between adiponectin levels in paediatric subjects with type 1 diabetes and those in healthy control subjects (26). Another study in children with type 1 diabetes found higher levels of adiponectin in pre-pubertal but not in pubertal children with type 1 diabetes compared with healthy children (27). No information about the influence of puberty on serum levels of adiponectin is available.…”

Section: Introductionmentioning

confidence: 97%

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Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Galler¹,

Gelbrich²,

Kratzsch³

et al. 2007

eur j endocrinol

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Objective: Adiponectin plays an important role in pathophysiology of obesity, type 2 diabetes and cardiovascular disease. The aim of this study was to determine adiponectin concentrations in children and adolescents with type 1 diabetes in a longitudinal manner and to study the impact of age, gender, body mass index (BMI) and metabolic control. Research design and methods: In this study, 88 children and adolescents with type 1 diabetes were followed longitudinally. At baseline and during follow-up, serum levels of adiponectin were measured by enzyme-linked immunoassay and correlated with clinical data, HbA1c and lipids. Healthy children (nZ259) were chosen as a control group. Results: Serum adiponectin levels were significantly higher in children with type 1 diabetes compared with healthy children (13.1 vs 9.1 mg/ml at baseline, P!0.001). Adiponectin concentrations inversely correlated with BMI S.D.s (P!0.001). No significant difference of adiponectin levels regarding gender, diabetes duration or HbA1c was seen. Adiponectin concentrations decreased in males with type 1 diabetes during puberty (PZ0.03) while there was no significant change in females. In a subgroup of patients with new onset type 1 diabetes, adiponectin concentrations were not different from adiponectin levels in control subjects but increased during follow-up (PZ0.007). Stepwise multiple regression analysis showed that most important predictors of adiponectin levels in type 1 diabetes at the end of the study were adiponectin concentration at baseline (bZ0.574, P!0.001) and BMI S.D.s (bZK0.302, PZ0.001, r 2 Z0.56). Conclusions: Children and adolescents with type 1 diabetes have BMI-dependent elevated serum concentrations of adiponectin compared with healthy children.European Journal of Endocrinology 157 481-489

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Galler¹,

Gelbrich²,

Kratzsch³

et al. 2007

eur j endocrinol

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Serum adipokines as biomarkers of beta‐cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

Pham

Kolb

Mandrup-Poulsen

et al. 2013

Diabetes Metabolism Res

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Current literature in diabetes

2007

Diabetes Metabolism Res

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of diabetes/metabolism. Each bibliography is divided into 26 sections: 1 Reviews & Symposia; 2 General; 3 Genetics; 4 Epidemiology; 5 Immunology; 6 Obesity; 7 Prediction and Prevention; 8 Intervention: a) General; b) Care; c) Drug Therapy; d)Economics; e) Gene therapy; f) Nursing; g) Nutrition; h) Surgery; i) Transplantation; 9 Pathology and Complications: a) General; b) Cardiovascular; c) Eye disease; d) Gestational and fetal; e) Neurological; f) Podiatrical; g) Renal; 10 Endocrinology & Metabolism; 11 Experimental Studies; 12 Diagnosis and Techniques. Within each section, articles are listed in alphabetical order with respect to author

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Circulating adipocytokines in non‐diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development

Abstract: Circulating concentrations of adipocytokines are abnormal in Type 1 diabetic children, although the direction of change differs by cytokine. Pubertal development, in addition to insulin treatment and glycaemic control, also influences the concentrations.

Cited by 36 publications

References 47 publications

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Elevated serum levels of adiponectin in children, adolescents and young adults with type 1 diabetes and the impact of age, gender, body mass index and metabolic control: a longitudinal study

Serum adipokines as biomarkers of beta‐cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin

Current literature in diabetes

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