Circulating adhesion molecules ICAM-1, VCAM-1 and E-selectin in systemic vasculitis : marked differences between Wegener's granulomatosis and systemic lupus erythematosus

Abstract

Inflammatory systemic disorders with renal tissue damage require the adherence of polymorphonuclear leukocytes to the endothelium, which is mediated by cell surface adhesion molecules. This study measured the serum concentrations of circulating adhesion molecules [intercellular adhesion molecule 1 (cICAM-1), vascular cell adhesion molecule 1 (cVCAM-1), cE-selectin] by sandwich enzyme-linked immunosorbent assay in Wegener's granulomatosis (n = 25) and systemic lupus erythematosus (n = 50). Active Wegener's granulomatosis with cellular crescent formation was associated with significantly raised cICAM-1 levels, an elevated histological activity index, and a high rate of hemodialysis in comparison to Wegener's granulomatosis with fibrocellular crescents or lupus nephritis. The activity index and cICAM-1 levels can be used as parameters to predict renal outcome in Wegener's granulomatosis. cVCAM-1 levels in Wegener's granulomatosis were significantly higher in patients with hemodialysis compared to those without hemodialysis. In lupus nephritis only cVCAM-1, not cICAM-1 or cE-selectin, were significantly higher (P < 0.01) than controls. cVCAM-1 levels in both diseases were significantly higher than in controls. Only in Wegener's granulomatosis did cICAM-1 and cVCAM-1 levels decrease with clinical remission; in systemic lupus erythematosus the levels remained unchanged. cE-selectin levels were not significantly elevated in systemic vasculitis or collagen disease although individual patients revealed high serum concentrations. These data suggest that levels of circulating adhesion molecules reflect different pathophysiological processes in systemic vasculitis and collagen disease and may be used as markers of disease activity and renal outcome.

Monocyte-Related Determinants of Inflammation in Patients on Peritoneal Dialysis

“…Furthermore, we did not observe any significant correlation between the concentrations of sVCAM-1 and those of serum creatinine in the 25 patients having renal impairment and serum creatinine values ranging from 266 to 1,410 Ìmol/l. The increase in sVCAM-1 in patients on PD and in patients with renal insufficiency in the present investigation accords with previous experiences [17][18][19]. There is incomplete information on the half-life of circulating adhesion molecules and on whether renal impairment per se leads to an accumulation of adhesion molecules due to impaired elimination.…”

“…There is incomplete information on the half-life of circulating adhesion molecules and on whether renal impairment per se leads to an accumulation of adhesion molecules due to impaired elimination. Previous studies have been contradictory in this respect [17][18][19]. Mrowka and Sieberth [17] did not find any correlation between circulating VCAM-1 and serum creatinine in patients with chronic glomerulonephritis or in patients with systemic vasculitis.…”

“…Previous studies have been contradictory in this respect [17][18][19]. Mrowka and Sieberth [17] did not find any correlation between circulating VCAM-1 and serum creatinine in patients with chronic glomerulonephritis or in patients with systemic vasculitis. This is in accordance with the findings in the present study.…”

Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage

“…British Journal of Cancer (1998) 77(5) Saag, 1996), and also in non-malignant acute (infectious) and chronic diseases, such as acute infectious mononucleosis (Furukawa et al, 1993), P. falciparum malaria (Hvidd et al, 1993), autoimmune and viral hepatitis (Zohrens et al, 1993), alcoholic liver cirrhosis (Zohrens et al, 1993), extrinsic allergic alveolitis (Shijubo et al, 1995), acute attacks of bronchial asthma (Kobayashi et al, 1994), inflammatory bowel disease (Patel et al, 1995), systemic lupus erythematosus (Mrowka and Sieberth, 1994), active multiple sclerosis (Sharief et al, 1993;Tsukada et al, 1993;Rieckmann et al, 1995), diabetes (Roep et al, 1994) and chronic renal failure .…”

Lymphopenia in Wegener’s Granulomatosis

“…Additionally, cytokines, cytokine-receptor molecules and adhesion molecules in serum and plasma of WG patients were shown to be associated with clinical disease activity [14, 15], but are not commonly available markers for clinicians.…”