Circulating 25-hydroxyvitamin D levels in relation to blood pressure parameters and hypertension in the Shanghai Women's and Men's Health Studies

Abstract

Little is known about the association of circulating 25-hydroxyvitamin D (25[OH]D) and blood pressure (BP) parameters, and hypertension in non-Western populations that have not yet been exposed to foods fortified with vitamins and seldom use vitamin D supplements. A cross-sectional analysis of plasma 25(OH)D levels in association with BP measures was performed for 1460 participants (405 men and 1055 women, aged 40–75 years) of two large cohort studies in Shanghai. Multivariable linear and logistic regressions were conducted. Overall, the prevalence of vitamin D deficiency was 55.8% using NHANES/USA criteria and 29.9% using WHO criteria. The median plasma 25(OH)D level was 38.0 nmol/L for men and 33.6 nmol/L for women (P<0.01) among subjects who were not on antihypertensive drugs. Among men, BP parameters (systolic BP, diastolic BP, and MAP) were significantly and inversely associated with higher quintiles of 25(OH)D compared with the lowest quintile (Ptrend <0.05 for all). Vitamin D non-deficient status (WHO criteria) was inversely associated with hypertension (ORadj =0.29, 95% CI: 0.10–0.82). An inverse association was also found between hypertension and the highest quintile of 25(OH)D (ORadj =0.16, 95% CI: 0.04–0.65 for ≥50.6 nmol/L; Ptrend =0.02). Among women, no significant associations were found for BP parameters and hypertension. The present study shows that vitamin D deficiency is common among adults in urban China. Circulating 25(OH)D levels were inversely related to levels of individual BP parameters and hypertension among middle-aged and elderly men but not in women. More research is needed to investigate the potential gender differential associations.

Dissociation between Low Vitamin D Level and Hypertension in Coal Mine Workers: Evidence from the Kailuan Study

“…However, in agreement with the present study, two large cross-sectional studies, the Amsterdam Longitudinal Aging Study and the Rancho-Bernardo Study, did not document a significant association (16,17). To the best of our knowledge, there are a handful of studies that have focused on the relationship between vitamin D and hypertension in ethnic Chinese patients (29)(30)(31). In accordance with the present study, Li et There are several potential explanations for the lack of an association between vitamin D and hypertension observed in this study.…”

Analysis of 25(OH)D Serum Concentrations of Hospitalized Elderly Patients in the Shanghai Area

“…This is supported by Douglas et al, who reported that the incidence and mortality rates of coronary heart diseases showed a strong seasonal pattern with higher rates in winter, when vitamin D levels are lowest[30]. 25(OH)D serum levels of our hypertension patients were above the average, which is contrary to a report that increasing vitamin D uptake alleviates hypertension [31]. On the other hand, it is note-worthy that 25(OH)D2 serum levels of hypertension patient were lower than those of patients with other diseases and further investigations are necessary for an explanation at present.…”

Concentrações de 25-hidroxivitamina D e níveis pressóricos em idosos hipertensos

“…ao identificarem que o tratamento da vitamina D sobre a hipertensão arterial em humanos por três semanas acarretou uma diminuição de 9% da pressão arterial sistólica (7). Relação inversa significativa entre 25-hidroxivitamina D e pressão arterial sistólica e diastólica também foi confirmada recentemente em homens, mas não em mulheres em Xangai e em uma população indiana (37,38), corroborando com os dados do Health Professionals Follow-up Study (HPFS) e do Nurse's Health Study, nos quais foi possível concluir que os níveis 25-hidroxivitamina D são inversamente associados ao risco de desenvolver hipertensão (8). Todos esses estudos pré-vios mencionam os mesmos mecanismos pelos quais a vitamina D reduz a pressão arterial, mas não faz distinção entre a pressão arterial sistólica e diastólica.…”