Analysis of 25(OH)D Serum Concentrations of Hospitalized Elderly Patients in the Shanghai Area

Mao, Xudong; Zheng, Huimin; Liu, Zhiwen; Wu, Yan; Na, Risu; Wang, Chunping; Zheng, Xulei; Gao, Jing; Wu, Liming; Shi, Xia; Liu, Cong

doi:10.1371/journal.pone.0090729

Cited by 9 publications

(6 citation statements)

References 27 publications

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“…Mao et al . raise a point of caution on the possibility that the cut off points as suggested by the Institute of Medicine, which are based on skeletal health for a predominantly Caucasian population, may not be ideal for other races in other settings [ 37 ]. It might therefore be prudent to establish local reference intervals for different settings and racial groups.…”

Section: Discussionmentioning

confidence: 99%

Association of high serum vitamin D concentrations with active pulmonary TB in an HIV co-endemic setting, Harare, Zimbabwe

et al. 2017

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BackgroundThere is paucity data on the association of vitamin D deficiency (VDD) and active tuberculosis (TB) in southern Africa where the human immunodeficiency virus (HIV) is co-endemic. We examined the association of serum vitamin D concentrations with active pulmonary tuberculosis (PTB) in HIV-infected (n = 284) and uninfected (n = 267) Black Zimbabweans, in Harare, Zimbabwe.MethodsWe conducted a cross-sectional study of 551 participants comprising 145 HIV+/PTB +, 139 HIV+/PTB−, 134 HIV−/PTB+ and 133 HIV−/PTB−. PTB status was confirmed using sputum by culture, or smear microscopy, or GeneXpert MTB/RIF. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured using a competitive chemiluminescent immunoassay prior to commencement of anti-TB treatment.ResultsIn all four groups, the median vitamin D concentrations were above the 20 ng/ml cut off for VDD. However, the median vitamin D concentrations in all the four groups were below the cut off for vitamin D sufficiency ≥30 ng/ml. The median vitamin D concentrations were significantly higher in PTB+ cases; 24.2 ng/ml (IQR: 18.8–32.0) compared to PTB− controls 20.9 ng/ml (IQR: 17.1–26.9), p < 0.0001 regardless of HIV status. The HIV+/PTB+ group had the highest median vitamin D concentration (25.3 (IQR: 18.0–33.7 ng/ml) whilst the HIV+/PTB− group had the lowest; 20.4 ng/ml (IQR: 14.6–26.9), p = 0.0003. Vitamin D concentration <30 ng/ml was associated with 43% lower odds of being PTB+ OR 0.57 (95% CI 0.35–0.89).ConclusionsOur results are not in agreement with the generally accepted hypothesis that VDD is associated with active PTB. To the contrary our results showed an association of higher vitamin D concentrations with active TB irrespective of HIV status. Although findings from the available pool of case control studies remain inconsistent, the results from the current study provide further rationale for larger-scale, prospectively designed studies to evaluate whether sufficient vitamin D concentrations do indeed precede the development of active PTB in our setting.

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Section: Discussionmentioning

confidence: 99%

Association of high serum vitamin D concentrations with active pulmonary TB in an HIV co-endemic setting, Harare, Zimbabwe

et al. 2017

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“…Table 1 The increasing prevalence of vitamin D deficiency with age was also reported in the US NHANES III report earlier (1988-1994) [24], and study by [25] found that efficiency of vitamin D synthesis which occurs in layer of skin is decreased with the aging process. In [12,26] According to MNA-SF scores, majority of elderly people in this present study is at risk of malnutrition (48.9%) and some were even malnourished (29.8%). In [27] had observed that there was no improvement in percentage of under-nutrition in shelter homes, even though regular and nutritious meals and health care facilities were provided.…”

Section: Resultsmentioning

confidence: 62%

“…Factors such as obesity, vitamin D supplement use and genetic markers were also significantly associated with 25(OH)D concentrations. In addition, other behavioural factors may also influence the serum vitamin D concentrations, such as indoor lifestyles, sunscreen overuse, and lower intakes of vitamin D [12]. In [3] stated that a low vitamin D is highly prevalent among chronic illnesses, including common cancers, autoimmune diseases, infectious diseases, cardiovascular diseases and chronic obstructive pulmonary disease (COPD) [14].…”

Section: Introductionmentioning

confidence: 99%

Association between serum 25-hydroxyvitamin D level and anthropometric indices among institutionalized elderly people in Kelantan, Malaysia

Shafie

Taha

Zainuddin

et al. 2018

J. Fundam and Appl Sci.

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Elderly people in institutionalized home care might deficiencies due to lack of food intake and comorbidities. This study was intended to investigate the prevalence of vitamin D deficiency among institutionalized elderly people and association between anthropometric from Kelantan, age 60 years and above were interviewed for socio anthropometry measurements. The mean serum 25(OH)D level among elderly was 54.9 ± 19.4 nmol/l shows most of the elder but none were classified having vitamin D deficiency. In was not prevalent among institutionalized elderly in Malaysia and nutritional status has no or less effect on serum 25(OH)D level.

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“…Another possibility is the nutritional and environmental differences between New Brunswick and Changsha. The lower 25 (OH) D levels in Chinese patients may reflect low vitamin D intake or less sun exposure [ 7 , 8 ]. Although serum 25 (OH) D levels are higher (14.2 ng/mL) than those in cohorts from Shanghai (13 ng/mL) and Beijing (8.8 ng/mL), the levels are still much lower than those in patients from New Brunswick (28.0 ng/mL).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha

Meng

Liu

Al-Dayyeni

et al. 2018

International Journal of Endocrinology

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Purpose To compare the initial clinical features, laboratory values, and bone mineral density among patients with primary hyperparathyroidism (PHPT) in Changsha (China) and New Brunswick (USA). Methods In this retrospective study, we reviewed 169 PHPT patients who presented at Robert Wood Johnson University Hospital and 133 PHPT patients who presented at the Second Xiangya Hospital of Central South University in the same time period. The following characteristics were compared between the groups: age, gender, BMI, serum calcium, alkaline phosphatase (AKP), albumin, intact PTH (iPTH), 25-hydroxyvitamin D (25 (OH) D), fasting blood glucose levels, and bone mineral density (BMD). All these parameters were also compared according to gender and menopausal status. iPTH associations were also assessed along with several other parameters. Results PHPT patients from Changsha had higher serum calcium, iPTH, and AKP levels but lower 25 (OH) D levels than the patients from New Brunswick (p < 0.05). Patients in Changsha had lower T-scores and Z-scores in both the lumbar spine and hip regions than those in New Brunswick (p < 0.05). Patients in New Brunswick had lower percentages of parathyroid adenoma and kidney stones. Serum iPTH level was positively correlated with serum calcium and serum AKP levels in both Changsha and New Brunswick (p < 0.05). Conclusions There are distinct biochemical and clinical differences between patients with PHPT in China and the United States. Our study revealed that Asian PHPT patients from Changsha presented more severe PHPT profiles, lower bone mineral density, and higher incidence of renal stones.

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Analysis of 25(OH)D Serum Concentrations of Hospitalized Elderly Patients in the Shanghai Area

Cited by 9 publications

References 27 publications

Association of high serum vitamin D concentrations with active pulmonary TB in an HIV co-endemic setting, Harare, Zimbabwe

Association of high serum vitamin D concentrations with active pulmonary TB in an HIV co-endemic setting, Harare, Zimbabwe

Association between serum 25-hydroxyvitamin D level and anthropometric indices among institutionalized elderly people in Kelantan, Malaysia

Comparison of Initial Clinical Presentations between Primary Hyperparathyroidism Patients from New Brunswick and Changsha

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