Circular RNAs in human cancer

Wang, Yumin; Mo, Yongzhen; Gong, Zhaojian; Xiang, Yang; Yang, Mo; Zhang, Shanshan; Xiong, Fang; Xiang, Bo; Zhou, Ming; Liao, Qianjin; Zhang, Wenling; Li, Xiayu; Li, Xiaoling; Li, Yong; Li, Guiyuan; Zeng, Zhaoyang; Xiong, Wei

doi:10.1186/s12943-017-0598-7

Cited by 313 publications

(262 citation statements)

References 59 publications

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“…With the increasing studies about circRNAs, researchers have reported that circRNAs are involved in the development of several types of diseases, such as cancer [19], cardiovascular disease [20], and neurological disorders [21]. Recently, several studies have revealed circRNAs can be used as diagnostic or predictive biomarkers for many human diseases [22, 23].…”

Section: Discussionmentioning

confidence: 99%

Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients

Huang

Yao²,

et al. 2018

Cell Physiol Biochem

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Background/Aims: Dysregulated expression of circular RNAs (circRNAs) was demonstrated to be implicated in many diseases. Here, we aimed to determine circRNA profile in peripheral blood mononuclear cells (PBMCs) from active tuberculosis (TB) patients to identify novel biomarkers for TB. Methods: Expression profile of circRNAs in PBMCs from 3 active pulmonary TB patients and 3 healthy controls were analyzed by microarray assay. Six circRNAs were selected for validation using real time-quantitative PCR (qRT-PCR) in 40 TB patients and 40 control subjects. Receiver operating characteristic (ROC) curve was constructed to evaluate their values in TB diagnosis. Hsa_circRNA_001937 was chosen for further evaluation in an independent cohort consisting of 115 TB, 40 pneumonia, 40 COPD, 40 lung cancer patients and 90 control subjects. An eight-month follow up was performed in 20 newly diagnosed TB patients to investigate the expression change of hsa_circRNA_001937 after chemotherapy. Results: We revealed and confirmed that a number of circRNAs were dysregulated in TB patients. Of the six studied physio circRNAs, the levels of hsa_circRNA_001937, hsa_circRNA_009024 and hsa_ circRNA_005086 were significantly elevated and hsa_circRNA_102101, hsa_circRNA_104964 and hsa_circRNA_104296 were significantly reduced in PBMCs from TB patients as compared to healthy controls. ROC curve analysis suggested that hsa_circRNA_001937 has the largest area under the curve (AUC = 0.873, P<0.001). Hsa_circRNA_001937 was significantly increased in patients with TB compared with patients with pneumonia, COPD and lung cancer. Hsa_ circRNA_001937 was correlated with TB severity (r = 0.4053, P = 0.010) and its expression significantly decreased after treatment. Conclusion: This study identified a set of deregulated circRNAs in active TB PBMCs, our data also suggest that hsa_circRNA_001937 can be used as a potential diagnostic biomarker of TB.

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Section: Discussionmentioning

confidence: 99%

Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients

Huang

Yao²,

et al. 2018

Cell Physiol Biochem

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“…After siRNA-mediated silencing of LINC00673 , we found that could significantly inhibit TSCC cancer cell invasive and migratory abilities. In recent findings, some lncRNAs, such as actin filament associated protein 1 antisense RNA1 ( AFAP1-AS1 ) [44, 45], HOX transcript antisense RNA ( HOTAIR ) [46], growth-arrest-specific transcript 5 ( GAS5 ) [47], have been reported to regulate cancer metastasis process by multiple ways. The potential role of LINC00673 abnormalities in TSCC is worth for further investigated.…”

Section: Discussionmentioning

confidence: 99%

Overexpression long non-coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma

Liu

Gong

et al. 2016

Oncotarget

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Long non-coding RNAs (lncRNAs) associated with the tumorigenesis of human cancers. However, the relevance of lncRNAs in tongue squamous cell carcinoma (TSCC) is still unclear. To discover novel TSCC-related lncRNAs, we analyzed the lncRNA expression patterns in two sets of TSCC gene expression profile data, and found that long intergenic non-coding RNA 673 (LINC00673) was significantly upregulated in TSCC samples. Then we examined LINC00673 expression in 202 TSCC tissue specimens, LINC00673 is highly expressed in a significant proportion of human TSCC biopsies and correlates with poor prognosis. Knockdown LINC00673 significantly inhibited the cell invasion and migration capability in TSCC cells. Our findings suggest that LINC00673 may play an essential role in TSCC progression and might serve as a potential biomarker for early detection and prognosis prediction of TSCC.

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“…Although researchers now have an understanding of most characteristics of cancer 2-30, the characteristics regarding cancer formation, which is the focus of the current study, remains unknown. After the 'ecological therapy' strategy was widely employed 31, much effort has been devoted to determining how cellular and noncellular components of the tumoral niche help tumors to acquire these characters.…”

Section: Introductionmentioning

confidence: 99%

Role of tumor microenvironment in tumorigenesis

et al. 2017

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Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenvironment (TME) is closely connected to every step of tumorigenesis. Evidence suggests that the vital components of the TME are fibroblasts and myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory cells, the blood and lymphatic vascular networks, and ECM. This manuscript, based on the current studies of the TME, offers a more comprehensive overview of the primary functions of each component of the TME in cancer initiation, progression, and invasion. The manuscript also includes primary therapeutic targeting markers for each player, which may be helpful in treating tumors.

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Circular RNAs in human cancer

Cited by 313 publications

References 59 publications

Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients

Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients

Overexpression long non-coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma

Role of tumor microenvironment in tumorigenesis

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