Long non-coding RNAs (lncRNAs) associated with the tumorigenesis of human cancers. However, the relevance of lncRNAs in tongue squamous cell carcinoma (TSCC) is still unclear. To discover novel TSCC-related lncRNAs, we analyzed the lncRNA expression patterns in two sets of TSCC gene expression profile data, and found that long intergenic non-coding RNA 673 (LINC00673) was significantly upregulated in TSCC samples. Then we examined LINC00673 expression in 202 TSCC tissue specimens, LINC00673 is highly expressed in a significant proportion of human TSCC biopsies and correlates with poor prognosis. Knockdown LINC00673 significantly inhibited the cell invasion and migration capability in TSCC cells. Our findings suggest that LINC00673 may play an essential role in TSCC progression and might serve as a potential biomarker for early detection and prognosis prediction of TSCC.
Antimony (Sb) has been pursued as a promising anode material
for
sodium-ion batteries (SIBs). However, it suffers from severe volume
expansion during the sodiation–desodiation process. Encapsulating
Sb into a carbon matrix can effectively buffer the volume change of
Sb. However, the sluggish Na+ diffusion kinetics in traditional
carbon shells is still a bottleneck for achieving high-rate performance
in Sb/C composite materials. Here we design and synthesize a yolk–shell
Sb@Void@graphdiyne (GDY) nanobox (Sb@Void@GDY NB) anode for high-rate
and long cycle life SIBs. The intrinsic in-plane cavities in GDY shells
offer three-dimensional Na+ transporting channels, enabling
fast Na+ diffusion through the GDY shells. Electrochemical
kinetics analyses show that the Sb@Void@GDY NBs exhibit faster Na+ transport kinetics than traditional Sb@C NBs. In
situ transmission electron microscopy analysis reveals that
the hollow structure and the void space between Sb and GDY successfully
accommodate the volume change of Sb during cycling, and the plastic
GDY shell maintains the structural integrity of NBs. Benefiting from
the above structural merits, the Sb@Void@GDY NBs exhibit excellent
rate capability and extraordinary cycling stability.
A portable multichannel surface plasmon resonance (SPR) biosensor device is presented in this study. As an optical biosensor device, the core component of its light path is a semi-cylindrical prism, which is used as the coupling unit for the excitation of the SPR phenomena. Based on this prism, a wedge-shaped incident light beam including a continuous angle range (10°) is chosen to replace the commonly-used parallel light beam in traditional SPR devices, in which the incident angle is adjusted by a sophisticated mechanical system. Thus, complicated, cumbersome, and costly mechanical structures can be avoided in this design. Furthermore, the selection of a small and high-stability semiconductor laser and matrix CCD detector as well as a microfluidic system aids in the realization of a miniaturized and multichannel device. Several different samples were used to test the performance of this new device. For ethanol with different concentrations, the sensing response was of good linear relativity with the concentration (Y = 3.17143X + 2.81518, R2 = 0.97661). Mouse IgG and goat anti-mouse IgG were used as biological samples for immunological analysis, and BSA as the control group. Good specific recognition between mouse IgG and goat anti-mouse IgG has been achieved. The detection limit of antibody to antigen coated on the sensing surface was about 25 mg/L without surface modification.
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