Circular RNA profile of infantile hemangioma by microarray analysis

Fu, Cong; Lv, Ruihua; Xu, Guangqi; Zhang, Linfeng; Bi, Jianhai; Lin, Li; Liu, Xiaowen; Huo, Ran

doi:10.1371/journal.pone.0187581

Cited by 22 publications

(18 citation statements)

References 49 publications

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“…[2] The pathogenesis of hemangioma has been widely studied, and several theories have been proposed, among which endothelial progenitor cell theory, Folkman Klagsbrun placental theory, angiogenesis theory, and hypoxia theory are the most accepted. [23] To date, circRNA profiles by microarray analysis in the IHs have been reported, [11] and 234 up- and 374 downregulated circRNAs were identified in IH by microarray. [11] In this study, based on the RNA-Seq technique, we found that 249 circRNAs are dysregulated in IH including 124 upregulated and 125 downregulated circRNAs.…”

Section: Discussionmentioning

confidence: 99%

“…[23] To date, circRNA profiles by microarray analysis in the IHs have been reported, [11] and 234 up- and 374 downregulated circRNAs were identified in IH by microarray. [11] In this study, based on the RNA-Seq technique, we found that 249 circRNAs are dysregulated in IH including 124 upregulated and 125 downregulated circRNAs.…”

Section: Discussionmentioning

confidence: 99%

“…[25] Our circRNA profile in IHs was not completely consistent with the microarray data. [11] According to the origin genes, we found that 47 origin genes of the 249 dysregulated circRNAs detected using RNA-Seq could be found in the circRNA microarray data (fold change ≥ 2, P < .5).…”

Section: Discussionmentioning

confidence: 99%

“…For the origin genes of the validated 6 circRNAs (Table 3), we found that TM7SF3 and GUCY1A2 also could be found in the microarray data lists. [11] Thus, hsa_circRNA002136 and hsa_circRNA001885 may be the most promising research objects. TM7SF3 can maintain protein homeostasis and promote cell survival through the attenuation of endoplasmic reticulum stress.…”

Section: Discussionmentioning

confidence: 99%

“…The circRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2, and CTGF in cardiac fibroblasts. [10] Recently, circRNA profiles of IH were elucidated by microarray analysis, [11] exhibiting the prospect of studying circRNAs in IHs.…”

Section: Introductionmentioning

confidence: 99%

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Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq

Li²,

Chen³

et al. 2018

Medicine

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We found that of the 9811 identified circRNAs, 249 candidates were differentially expressed, including 124 upregulated and 125 downregulated circRNAs in the IH group compared with the matched normal skin control group. A set of differentially expressed circRNAs (in particular, hsa_circRNA001885 and hsa_circRNA006612 expression) were confirmed using qRT-PCR. Gene ontology and pathway analysis revealed that compared to matched normal skin tissues, many processes that were over-represented in IH group were related to the binding, protein binding, gap junction, and focal adhesion. Specific circRNAs were associated with several micro-RNAs (miRNAs) predicted using miRanda. Altogether, our findings highlight the potential importance of circRNAs in the biology of IH and its response to treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq

Li²,

Chen³

et al. 2018

Medicine

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CircAP2A2 acts as a ceRNA to participate in infantile hemangiomas progression by sponging miR‐382‐5p via regulating the expression of VEGFA

Yuan¹,

Xu²,

Wei³

et al. 2020

Clinical Laboratory Analysis

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Background Increasing evidences reveal that circular RNAs (circRNAs) play crucial functions in cancer development. However, the expression pattern and roles of circRNAs in infantile hemangiomas (IH) remain unclear. Methods In this study, qRT‐PCR was performed to determine the expression of circAP2A2, miR‐382‐5p, and VEGFA in IH tissues and cell lines. Moreover, MTT assay, colony formation, transwell assay, and Western blot analysis were conducted to assess the function of circAP2A2 or miR‐382‐5p on cell proliferation, and migration in vitro, respectively. Also, dual luciferase assay was used to confirm the interactions among circAP2A2, miR‐382‐5p, and VEGFA. Results CircAP2A2 was confirmed to be highly expressed in IH. CircAP2A2 knockdown or miR‐382‐5p overexpression decreased the proliferation, colony formation, migration, and invasion of HemECs and HUVEC cells. Conclusion CircAP2A2 could promote proliferation and invasion of IH by regulating miR‐382‐5p/VEGFA axis.

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Curcumin enhances radiosensitization of nasopharyngeal carcinoma by regulating circRNA network

Yang

Zhu

Liu

et al. 2019

Molecular Carcinogenesis

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Circular RNAs (circRNAs) are involved in the regulation of gene expression in different physiological and pathological processes. These macromolecules can act as microRNA (miRNA) sponges and play an important role as gene regulators throughout the circRNA‐miRNA pathway. In this study, we established a radioresistance model with the nasopharyngeal carcinoma cell line CNE‐2, and then analyzed the differences in the circRNAs between radioresistant and normal nasopharyngeal carcinoma cell lines using a high‐throughput microarray. Tested circRNAs included 1042 upregulated and 1558 downregulated circRNAs. Relevant signaling pathways associated with the circRNAs and their target miRNAs were analyzed using bioinformatics analysis to determine the radioresistance of the differentially expressed circRNAs. Curcumin was used to treat irradiated cell lines, and changes in the circRNA before and after curcumin treatment were analyzed to investigate the radiosensitization effects of curcumin. The results showed that curcumin could regulate the circRNA‐miRNA‐messenger RNA network and inhibit the epidermal growth factor receptor (EGFR), signal transducers and activators of transcription 3 (STAT3), and growth factor receptor‐bound protein 2 (GRB2) to achieve radiosensitization. Thus, circRNA acted as a miRNA sponge and regulated the expression of miRNA, thereby affecting EGFR, STAT3, and GRB2 expression and radiosensitization.

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Circular RNA profile of infantile hemangioma by microarray analysis

Cited by 22 publications

References 49 publications

Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq

Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq

CircAP2A2 acts as a ceRNA to participate in infantile hemangiomas progression by sponging miR‐382‐5p via regulating the expression of VEGFA

Curcumin enhances radiosensitization of nasopharyngeal carcinoma by regulating circRNA network

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