Circular RNA mmu_circ_0001295 from hypoxia pretreated adipose-derived mesenchymal stem cells (ADSCs) exosomes improves outcomes and inhibits sepsis-induced renal injury in a mouse model of sepsis

Cao, Shan; Huang, Ying; Dai, Zhenzhao; Liao, Yang; Zhang, Jinfeng; Wang, Lingli; Hao, Zhiyan; Wang, Fei; Wang, Dan; Liu, Lixiao

doi:10.1080/21655979.2022.2044720

Cited by 20 publications

(11 citation statements)

References 33 publications

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“…In EVs of sepsis, other types of non-coding RNAs were also altered, including lncRNAs ( Ma et al., 2021 ; Sui et al., 2021a ; Liang et al., 2022 ; Wei et al., 2022 ), circRNAs ( Cao et al., 2022 ), and Y-RNA ( Driedonks et al., 2020 ). Studies have shown that lncRNA NEAT1 carried by EVs in sepsis was associated with the aggravation of sepsis-related encephalopathy ( Wei et al., 2022 ), lncRNA TUG1 was involved in promoting macrophage M2 polarization ( Ma et al., 2021 ), and lncRNA-p21 can inhibit LPS-induced lung cells injury, lncRNA IGF2-AS promoted endothelial progenitor cell pyroptosis ( Sui et al., 2021a ; Liang et al., 2022 ).…”

Section: Cargoes Of Evs In Sepsismentioning

confidence: 99%

“…Hsa_circRNA_104484 and hsa_circRNA_104670 were up-regulated in serum exosomes of patients with sepsis, which may serve as diagnostic markers for sepsis ( Tian et al., 2021 ). Mmu_circ_0001295 in exosomes was involved in alleviating septic kidney injury ( Cao et al., 2022 ). The cell-type-specific Y-RNA isoform ratios in plasma EVs were altered in a human endotoxemia model and closely correlated with inflammation-induced changes in circulating neutrophil and monocyte numbers ( Driedonks et al., 2020 ).…”

Section: Cargoes Of Evs In Sepsismentioning

confidence: 99%

“…In addition, it also exerted a protective effect on endothelial cells (ECs) through the miR-126-PI3K/Akt pathway and alleviated histone-induced acute lung injury ( Mizuta et al., 2020 ). mmu_circ_0001295 in exosomes of ADSCs pretreated with hypoxia was involved in alleviating sepsis-related renal injury ( Cao et al., 2022 ).…”

Section: Evs Derived From Different Cell Types In Sepsismentioning

confidence: 99%

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Extracellular vesicles participate in the pathogenesis of sepsis

Tian

Wang

Zhao

et al. 2022

Front. Cell. Infect. Microbiol.

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Sepsis is one of the leading causes of mortality worldwide and is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The early diagnosis and effective treatment of sepsis still face challenges due to its rapid progression, dynamic changes, and strong heterogeneity among different individuals. To develop novel strategies to control sepsis, a better understanding of the complex mechanisms of sepsis is vital. Extracellular vesicles (EVs) are membrane vesicles released from cells through different mechanisms. In the disease state, the number of EVs produced by activated or apoptotic cells and the cargoes they carry were altered. They regulated the function of local or distant host cells in autocrine or paracrine ways. Current studies have found that EVs are involved in the occurrence and development of sepsis through multiple pathways. In this review, we focus on changes in the cargoes of EVs in sepsis, the regulatory roles of EVs derived from host cells and bacteria, and how EVs are involved in multiple pathological processes and organ dysfunction in sepsis. Overall, EVs have great application prospects in sepsis, such as early diagnosis of sepsis, dynamic monitoring of disease, precise therapeutic targets, and prevention of sepsis as a vaccine platform.

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Section: Cargoes Of Evs In Sepsismentioning

confidence: 99%

Section: Cargoes Of Evs In Sepsismentioning

confidence: 99%

Section: Evs Derived From Different Cell Types In Sepsismentioning

confidence: 99%

See 1 more Smart Citation

Extracellular vesicles participate in the pathogenesis of sepsis

Tian

Wang

Zhao

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Targeted methods that are being tested include the use of interfering RNA, the delivery of circRNA overexpression via lentivirus- or adenovirus-based vectors, the delivery of circRNA via nanoparticles such as liposomes, the creation of synthetic circRNAs, and the administration of exosomes containing circRNAs, among other methods [ 98 ]. Encouragingly, intravenous administration of mmu_circ_0001295 derived from hypoxia pre-treated adipose-derived mesenchymal stem cell (ADSC) exosomes directly into CLP mice led to the amelioration of tissue inflammation and injury and the attenuation of kidney dysfunction [ 99 ]. Synthetic circRNAs have also been constructed for the treatment of other diseases, although they remain at a very early stage of development [ 100 , 101 , 102 ].…”

Section: Potential Clinical Applications Of Circrnas In Akimentioning

confidence: 99%

Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management

Yap

Chan

2022

IJMS

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Acute kidney injury (AKI) is a common clinical condition, results in patient morbidity and mortality, and incurs considerable health care costs. Sepsis, ischaemia-reperfusion injury (IRI) and drug nephrotoxicity are the leading causes. Mounting evidence suggests that perturbations in circular RNAs (circRNAs) are observed in AKI of various aetiologies, and have pathogenic significance. Aberrant circRNA expressions can cause altered intracellular signalling, exaggerated oxidative stress, increased cellular apoptosis, excess inflammation, and tissue injury in AKI due to sepsis or IRI. While circRNAs are dysregulated in drug-induced AKI, their roles in pathogenesis are less well-characterised. CircRNAs also show potential for clinical application in diagnosis, prognostication, monitoring, and treatment. Prospective observational studies are needed to investigate the role of circRNAs in the clinical management of AKI, with special focus on the safety of therapeutic interventions targeting circRNAs and the avoidance of untoward off-target effects.

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“…As critical mediators of intercellular communication, they can alter the behaviors of recipient cells by transmitting signals and transporting molecules into target cells. Recent studies have shown that ADSC-EXOs had therapeutic effects in many aspects of disease, including wound healing (17,18), organ diseases (19,20), neurodegenerative diseases (21,22), and cancer (23,24). In regeneration and wound healing, ADSC-EXOs modulate persistent inflammation, angiogenesis, and ECM reconstruction.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of exosomes from adipose-derived stem cells in chronic wound healing

et al. 2022

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Chronic wound healing remains a challenging medical problem affecting society, which urgently requires anatomical and functional solutions. Adipose-derived stem cells (ADSCs), mesenchymal stem cells with self-renewal and multiple differentiation ability, play essential roles in wound healing and tissue regeneration. The exosomes from ADSCs (ADSC-EXOs) are extracellular vesicles that are essential for communication between cells. ADSC-EXOs release various bioactive molecules and subsequently restore tissue homeostasis and accelerate wound healing, by promoting various stages of wound repair, including regulating the inflammatory response, promoting wound angiogenesis, accelerating cell proliferation, and modulating wound remodeling. Compared with ADSCs, ADSC-EXOs have the advantages of avoiding ethical issues, being easily stored, and having high stability. In this review, a literature search of PubMed, Medline, and Google Scholar was performed for articles before August 1, 2022 focusing on exosomes from ADSCs, chronic wound repair, and therapeutic potential. This review aimed to provide new therapeutic strategies to help investigators explore how ADSC-EXOs regulate intercellular communication in chronic wounds.

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Circular RNA mmu_circ_0001295 from hypoxia pretreated adipose-derived mesenchymal stem cells (ADSCs) exosomes improves outcomes and inhibits sepsis-induced renal injury in a mouse model of sepsis

Cited by 20 publications

References 33 publications

Extracellular vesicles participate in the pathogenesis of sepsis

Extracellular vesicles participate in the pathogenesis of sepsis

Circular RNAs in Acute Kidney Injury: Roles in Pathophysiology and Implications for Clinical Management

Therapeutic potential of exosomes from adipose-derived stem cells in chronic wound healing

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