Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302

Liu, Wei; Ma, Weiming; Yuan, Yuan; Zhang, Youwei; Sun, Shuai

doi:10.1016/j.bbrc.2018.04.172

Cited by 126 publications

(105 citation statements)

References 19 publications

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“…And these make the circular RNA a distinct advantage in the development and application as a novel clinical diagnostic marker. In addition, circular RNA may play a very important role by competitively binding disease‐associated microRNAs (miRNAs) in diseases such as bladder cancer, lung cancer, and gastric cancer (W. Liu, Ma, Yuan, Zhang, & Sun, ; Xu, Yang, Liu, & Su, ; Zhang et al, ). For example, W.R. Chen et al () revealed that “Extensive profiling of circular RNAs and the potential regulatory role of circRNA‐000284 in cell proliferation and invasion of cervical cancer via sponging miR‐506.”…”

Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circ_0000263 participates in cervical cancer development by regulating target gene of miR‐150‐5p

Cai

Zhang

et al. 2018

Journal Cellular Physiology

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Circular RNA (circRNA) is a new class of noncoding RNA, and plays an important role in many pathological processes. Cervical cancer is the most common gynecologic malignant tumor. Recently, studies have shown that there is a variety of circRNA involved in the pathogenesis of cervical cancer. We screened out the highly expressed hsa_circ_0000263 from GSE102686 by the quantitative real‐time polymerase chain reaction assay in cervical cancer cell lines. In this study, we investigated whether hsa_circ_0000263 might affect cell proliferation, migration, cell cycle and apoptosis in cervical cancer in vitro and in vivo. The luciferase reporter assay and RNA immunoprecipitation assay confirmed the direct interaction between miR‐150‐5p and hsa_circ_0000263. By using western blot and immunohistochemistry, we confirmed that hsa_circ_0000263 can regulate the expression of murine double minute 4 (MDM4) by affecting miR‐150‐5p, and finally affect the expression of p53 gene. We found that hsa_circ_0000263 was significantly upregulated in cervical cancer cells. In addition, the knockdown of hsa_circ_0000263, would inhibit cell proliferation and migration ability. In conclusion, our current research reveals the important role of hsa_circ_0000263/miR‐150‐5p/MDM4/p53 regulatory network in cervical cancer and provides a new insight into the pathogenesis of cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Circular RNA hsa_circ_0000263 participates in cervical cancer development by regulating target gene of miR‐150‐5p

Cai

Zhang

et al. 2018

Journal Cellular Physiology

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“…Cir‐ITCH can adhere to miR‐7 and miR‐214, thereby aggravating the inhibitory effect of ITCH on the downstream Wnt pathway . Hsa_circRNA_103809 adheres to miR‐4302, thereby increasing the proliferation and migration of lung cancer cells produced by MYC . Hsa_circ_0013958 was identified as a sponge for miR‐134, which promotes the progression of lung cancer by upregulating cyclin D1 .…”

Section: Introductionmentioning

confidence: 99%

“…9 Hsa_circRNA_103809 adheres to miR-4302, thereby increasing the proliferation and migration of lung cancer cells produced by MYC. 10 Hsa_circ_0013958 was identified as a sponge for miR-134, which promotes the progression of lung cancer by upregulating cyclin D1. 11 At present, the role of circ-IGF1R in lung cancer is still unclear, and its specific mechanisms are yet to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Circ‐IGF1Rinhibits cell invasion and migration in non‐small cell lung cancer

Xiang

Chen

et al. 2020

Thoracic Cancer

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Background Circular RNA (circRNA) is a novel molecular marker and target candidate that is closely associated with tumor invasion and migration. The mechanism of action of hsa_circ_0005035 (circ‐IGF1R) in non‐small cell lung cancer remains unclear. In this study, we aimed to study the mechanism of action of circ‐IGF1R in lung cancer. Methods We screened circ‐IGF1R, one of the most notable differential expressions, from the Gene Expression Omnibus database, GSE104854, for further research. The expression level of circ‐IGF1R was examined using quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) in five different lung cancer cell lines and 50 pairs of lung cancer and adjacent tissues. Wound‐healing and Transwell assays were used for verifying the biological function of circ‐IGF1R. The effect of overexpressing circ‐IGF1R on the transcriptome of whole lung cancer cells was explored in lung cancer cell lines using RNA‐seq. Results The expression level of circ‐IGF1R was notably lower in lung cancer tissues and lung cancer cell lines than in the adjacent normal tissues and cells (P < 0.0001). In addition, the expression level of circ‐IGF1R was associated with larger tumors (T2/T3/T4) and lymph node metastasis (N1/ N2/N3) (P < 0.05). The overexpression of circ‐IGF1R significantly inhibited the invasion and migration of the lung cancer cells. The potential network of circ‐IGF1R–miR‐1270–VANGL2 was preliminarily determined, and the expression patterns of miR‐1270 and VANGL2 were verified in lung cancer cell lines. Conclusion Circ‐IGF1R may inhibit lung cancer invasion and migration through a potential network of circ‐IGF1R–miR‐1270–VANGL2.

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“…Due to their closed structure, circRNAs are stable and resistant to RNA degradative pathways; circRNAs therefore show promise as novel molecular markers in various diseases, including cancer, myocardial infarction, diabetes, and cerebral infarction . The circRNAs function importantly in tumor progression and carcinogenesis in NSCLC . The circRNA hsa_circ_0014130 (circPIP5K1A) was identified as a novel biomarker that is highly overexpressed in tissues of NSCLC comparing with adjacent tissues .…”

Section: Introductionmentioning

confidence: 99%

“…11 The circRNAs function importantly in tumor progression and carcinogenesis in NSCLC. [12][13][14] The circRNA hsa_circ_0014130 (circPIP5-K1A) was identified as a novel biomarker that is highly overexpressed in tissues of NSCLC comparing with adjacent tissues. 15 However, the underlying regulatory mechanism remains unclear.…”

mentioning

confidence: 99%

Circular RNA circPIP5K1A promotes non‐small cell lung cancer proliferation and metastasis through miR‐600/HIF‐1α regulation

Chi

Luo

Song

et al. 2019

J of Cellular Biochemistry

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Circular RNAs (circRNAs) have an important function in human diseases, especially in cancer. circRNA hsa_circ_0014130 (circPIP5K1A), a particularly abundant circRNA, participates in the tumorigenesis of non‐small cell lung cancer (NSCLC), although the underlying regulatory mechanism remains unclear. Here, we investigated the circPIP5K1A role in NSCLC. Expression of circPIP5K1A in NSCLC cell lines was explored with quantitative real‐time PCR. The effect of circPIP5K1A on NSCLC was evaluated with circPIP5K1A silencing, miR‐600 mimic transfection, and hypoxia‐inducible factor (HIF)‐1α overexpression, followed by assessment of cell proliferation, metastasis, and tumorigenesis in nude mice. The subcellular localization of circPIP5K1A was evaluated via fluorescence in situ hybridization (FISH), and correlation between circPIP5K1A, miR‐600, and HIF‐1α was assessed by luciferase assay. The data demonstrated that circPIP5K1A expression was increased in NSCLC cells. FISH showed that circPIP5K1A localized to the cytoplasm. The circPIP5K1A knockdown suppressed NSCLC cell metastasis and proliferation by promoting expression of miR‐600. Overexpression of miR‐600 inhibited HIF‐1α‐mediated metastasis and proliferation of NSCLC cell by downregulating the endothelial mesenchymal transition‐related proteins, Snail and vimentin, and upregulating E‐cadherin. In vivo experiments illustrated that circPIP5K1A silence suppressed tumor growth and pulmonary metastasis. The circPIP5K1A may function as an miR‐600 sponge to facilitate NSCLC proliferation and metastasis by promoting HIF‐1α. A bifluorescein reporter experiment confirmed that miR‐600 was the circPIP5K1A target, and miR‐600 interacted with the 3′ untranslated region of HIF‐1α. These results show that circPIP5K1A acted as a tumor promoter through a novel circPIP5K1A/miR‐600/HIF‐1α axis, which provides candidate markers and therapeutic targets for NSCLC.

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Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302

Cited by 126 publications

References 19 publications

Circular RNA hsa_circ_0000263 participates in cervical cancer development by regulating target gene of miR‐150‐5p

Circular RNA hsa_circ_0000263 participates in cervical cancer development by regulating target gene of miR‐150‐5p

Circ‐IGF1Rinhibits cell invasion and migration in non‐small cell lung cancer

Circular RNA circPIP5K1A promotes non‐small cell lung cancer proliferation and metastasis through miR‐600/HIF‐1α regulation

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