Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR‐351‐5p

Yao, Qing; Liu, Ze; Yao, Aihong; Liu, Ji-Ting; Jiang, Jun; Chen, Yi; Li, Shanshan; Han, Yanyan; Jiang, Zong‐Lai; Qi, Ying‐Xin

doi:10.1002/jcp.29577

Cited by 15 publications

(12 citation statements)

References 40 publications

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“…39 In addition, circTET3 can mediate migration of rat vascular smooth muscle cells by targeting miR-351-5p. 40 These lines of evidence indicated that the molecules in this network are highly correlated with GC, and both play a role by targeting miRNA. Intriguingly, most of them showed distinct differences in expression after EBV infection.…”

Section: Dovepressmentioning

confidence: 95%

Comparative Transcriptome Provides a Systematic Perspective on Epstein–Barr Virus-Associated Gastric Carcinoma Cell Lines

Huang¹,

Chen²,

Bi³

et al. 2021

OTT

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Purpose: Epstein-Barr virus (EBV) is widely recognised to cause various tumours, and EBV-associated gastric carcinoma (EBVaGC) is a special type of GC. It has obviously different clinical features and pathological manifestations from EBV-negative gastric carcinoma, but its progression remains elusive. The underlying cancer progression of viral infection detected by genome-wide transcriptome analysis has been demonstrated in numerous diseases. Methods: We performed comparative RNA sequencing to identify gene expression signatures between GC and EBVaGC cell lines. The differentially expressed (DE) genes were analysed using gene ontology and pathway enrichment. Results: A total of 4438 DE mRNAs, 3650 DE long non-coding RNAs (lncRNAs), and 248 DE circular RNAs (circRNAs) were detected in GC cells after EBV infection, most of which were highly related to oncogenesis. Likewise, EBV-coding RNA and non-coding RNA were also well-supplemented in EBVaGC. According to bioinformatics, DE mRNAs may contribute to the completion of EBV-infected host cells and modulate mitosis. Binding to actin and participating in adherens junctions to promote contact between the virus and cells are a potential function of DE lncRNAs. The roles of DE circRNAs were enriched in DNA repair and protein modification, and a typical example of this is acting as an miRNA sponge. The establishment of a circRNA-miRNA-mRNA network helps to determine the key elements in the progression of EBVaGC. Conclusion:This study is the first to systematically reveal the transcriptome landscape of EBVaGC, which will provide an essential resource for genomic, genetic, and molecular mechanisms in the future.

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Section: Dovepressmentioning

confidence: 95%

Comparative Transcriptome Provides a Systematic Perspective on Epstein–Barr Virus-Associated Gastric Carcinoma Cell Lines

Huang¹,

Chen²,

Bi³

et al. 2021

OTT

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“… 205 Similarly, circRNAs also regulate vascular cells in ISR. circRNAs mediate EC proliferation (hsa_circ_0003575) 211 and migration (circ_0003204), 212 as well as VSMC proliferation (circ_Lrp6), 213 migration (circTET3), 214 and phenotypic transformation (circ-SATB2). 215 In the future, ISR may be treated by targeting circRNAs.…”

Section: Main Textmentioning

confidence: 99%

Targeting the epigenome in in-stent restenosis: from mechanisms to therapy

Yang

Guo

et al. 2021

Molecular Therapy - Nucleic Acids

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Coronary artery disease (CAD) is one of the most common causes of death worldwide. The introduction of percutaneous revascularization has revolutionized the therapy of patients with CAD. Despite the advent of drug-eluting stents, restenosis remains the main challenge in treating patients with CAD. In-stent restenosis (ISR) indicates the reduction in lumen diameter after percutaneous coronary intervention, in which the vessel’s lumen re-narrowing is attributed to the aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) and dysregulation of endothelial cells (ECs). Increasing evidence has demonstrated that epigenetics is involved in the occurrence and progression of ISR. In this review, we provide the latest and comprehensive analysis of three separate but related epigenetic mechanisms regulating ISR, namely, DNA methylation, histone modification, and non-coding RNAs. Initially, we discuss the mechanism of restenosis. Furthermore, we discuss the biological mechanism underlying the diverse epigenetic modifications modulating gene expression and functions of VSMCs, as well as ECs in ISR. Finally, we discuss potential therapeutic targets of the small molecule inhibitors of cardiovascular epigenetic factors. A more detailed understanding of epigenetic regulation is essential for elucidating this complex biological process, which will assist in developing and improving ISR therapy.

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“…It is therefore not surprising that deregulated expression of circRNAs is closely related to different types of diseases, such as degenerative diseases, tumor, congenital diseases, endocrine diseases and cardiovascular diseases ( Lukiw, 2013 ; Li et al, 2019a ; Chen et al, 2021a ; Li et al, 2021 ; Papatsirou et al, 2021 ). With relevance to clinical practice, tissue circRNAs could act as potential biomarkers for prognostication and diagnosis of diseases, particularly tumors ( Hu et al, 2019 ; Liu et al, 2020 ; Yao et al, 2020 ; Luo et al, 2021 ). Recently, several studies demonstrated that aberrant circRNA expression could contribute to the deregulated migration and proliferation of VSMCs ( Qin et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Emerging Roles of Circular RNAs in Vascular Smooth Muscle Cell Dysfunction

Yang

2022

Front. Genet.

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Atherosclerosis is the major pathophysiological basis of cerebrovascular and cardiovascular diseases. Vascular smooth muscle cells (VSMCs) constitute the main structure of vasculature and play important roles in maintaining vascular tone and blood pressure. Many biological processes and cellular signaling events involved in atherosclerogenesis have been shown to converge on deregulating VSMC functions. However, the molecular mechanisms underlying dysfunctional VSMC in atherosclerosis are still poorly defined. Recent evidence revealed that circular RNAs (circRNAs) are closely related to diseases such as degenerative diseases, tumor, congenital diseases, endocrine diseases and cardiovascular diseases. Several studies demonstrated that circRNAs (e.g., circACTA2, Circ-SATB2, circDiaph3, circ_0020397, circTET3, circCCDC66) played critical roles in the regulation of VSMC proliferation, migration, invasion, and contractile-to-synthetic phenotype transformation by sponging microRNAs (e.g., miR-548f-5p, miR-939, miR-148a-5p, miR-138, miR-351-5p, miR-342-3p). This review describes recent progress in the profiling of circRNAs by transcriptome analysis in VSMCs and their molecular functions in regulating VSMC proliferation and migration.

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Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR‐351‐5p

Cited by 15 publications

References 40 publications

Comparative Transcriptome Provides a Systematic Perspective on Epstein–Barr Virus-Associated Gastric Carcinoma Cell Lines

Comparative Transcriptome Provides a Systematic Perspective on Epstein–Barr Virus-Associated Gastric Carcinoma Cell Lines

Targeting the epigenome in in-stent restenosis: from mechanisms to therapy

Emerging Roles of Circular RNAs in Vascular Smooth Muscle Cell Dysfunction

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