Emerging Roles of Circular RNAs in Vascular Smooth Muscle Cell Dysfunction

Pu, Zuo; Lu, Jing-Bo; Yang, Xiaohan

doi:10.3389/fgene.2021.749296

Cited by 6 publications

(3 citation statements)

References 68 publications

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“…In the regulatory mechanisms of atherosclerosis (AS), several circRNAs have been implicated. Pu Z et al reported the involvement of circACTA2, circ-SATB2, and circCCDC66 in regulating vascular smooth muscle cell (VSMC) growth through miRNA sponging, thereby affecting AS formation [135]. Moreover, circRNAs have been shown to influence the onset and development of AS by regulating processes such as apoptosis, inflammatory response, and oxidative stress [136].…”

Section: Atherosclerosis (As)mentioning

confidence: 99%

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Jiang¹,

Hu²

2023

Clin. transl. rep.

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Cardiovascular and cerebrovascular diseases (CVD) encompass a range of conditions affecting the heart, brain, and blood vessels, including coronary heart disease, hypertension, and stroke. In recent years, there has been growing evidence highlighting the significant role of non-coding RNAs (ncRNAs) in the development and progression of cardiovascular diseases. Among the various types of ncRNAs, long-stranded non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have emerged as prominent players in cardiovascular research. Advancements in technology and in-depth research have revealed that ncRNAs and circRNAs exert regulatory effects on the biological functions of the cardiovascular system through various pathways. For instance, they can modulate the proliferation, migration, and apoptosis of vascular endothelial cells, as well as regulate cardiac muscle contraction and cardiomyocyte apoptosis. Additionally, ncRNAs and circRNAs can influence downstream targets and pathways involved in cardiovascular diseases. The exploration of ncRNAs and circRNAs in cardiovascular research has opened up new avenues for the diagnosis and treatment of CVDs. By understanding the intricate regulatory mechanisms mediated by these non-coding RNAs, researchers have gained valuable insights into the pathogenesis of cardiovascular diseases and identified potential therapeutic targets. Consequently, these studies have provided novel ideas and approaches for the diagnosis, prevention, and management of CVDs.

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Section: Atherosclerosis (As)mentioning

confidence: 99%

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Jiang¹,

Hu²

2023

Clin. transl. rep.

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“…Circular RNAs (circRNAs) are endogenous regulatory RNAs, which are covalently closed loops after reverse splicing due to the lack of 3’-poly-a tail and 5’- cap ( 80 ). Studies have demonstrated that most circRNAs regulate gene expression post-transcriptionally through sponging microRNAs (miRNAs), for example circACTA2, circ-SATB2, circDiaph3, circ_0020397, circTET3, circCCDC66, and miR-541, miR-195, miR-146a, miR-133, miR-214, miR-34a ( 81 , 82 ). It is suggested that circRNAs and miRNAs may be a new target spot and a new hot point in preventing dysfunctional VSMCs in AS.…”

Section: Mechanisms Of Vsmcs In Asmentioning

confidence: 99%

Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis

Lin

Yin²,

Yang³

et al. 2022

Front. Endocrinol.

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Atherosclerosis (AS) is a chronic inflammatory disease and leading cause of cardiovascular diseases. The progression of AS is a multi-step process leading to high morbidity and mortality. Hyperglycemia, dyslipidemia, advanced glycation end products (AGEs), inflammation and insulin resistance which strictly involved in diabetes are closely related to the pathogenesis of AS. A growing number of studies have linked AGEs to AS. As one of the risk factors of cardiac metabolic diseases, dysfunction of VSMCs plays an important role in AS pathogenesis. AGEs are increased in diabetes, participate in the occurrence and progression of AS through multiple molecular mechanisms of vascular cell injury. As the main functional cells of vascular, vascular smooth muscle cells (VSMCs) play different roles in each stage of atherosclerotic lesions. The interaction between AGEs and receptor for AGEs (RAGE) accelerates AS by affecting the proliferation and migration of VSMCs. In addition, increasing researches have reported that AGEs promote osteogenic transformation and macrophage-like transformation of VSMCs, and affect the progression of AS through other aspects such as autophagy and cell cycle. In this review, we summarize the effect of AGEs on VSMCs in atherosclerotic plaque development and progression. We also discuss the AGEs that link AS and diabetes mellitus, including oxidative stress, inflammation, RAGE ligands, small noncoding RNAs.

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“…circmTOR (circ_0009805) is overexpressed in severe preeclamptic placentas [309]. CircmTOR (circ_0009792) is upregulated in the proliferation of vascular smooth muscle cells [310] (Table 8). Other cell functions were rarely reported for this circmTOR.…”

Section: Akt Effectorsmentioning

confidence: 99%

Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells

Tang

Chuang

Shiau

et al. 2022

Cells

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AKT serine-threonine kinase (AKT) and its effectors are essential for maintaining cell proliferation, apoptosis, autophagy, endoplasmic reticulum (ER) stress, mitochondrial morphogenesis (fission/fusion), ferroptosis, necroptosis, DNA damage response (damage and repair), senescence, and migration of cancer cells. Several lncRNAs and circRNAs also regulate the expression of these functions by numerous pathways. However, the impact on cell functions by lncRNAs and circRNAs regulating AKT and its effectors is poorly understood. This review provides comprehensive information about the relationship of lncRNAs and circRNAs with AKT on the cell functions of cancer cells. the roles of several lncRNAs and circRNAs acting on AKT effectors, such as FOXO, mTORC1/2, S6K1/2, 4EBP1, SREBP, and HIF are explored. To further validate the relationship between AKT, AKT effectors, lncRNAs, and circRNAs, more predicted AKT- and AKT effector-targeting lncRNAs and circRNAs were retrieved from the LncTarD and circBase databases. Consistently, using an in-depth literature survey, these AKT- and AKT effector-targeting database lncRNAs and circRNAs were related to cell functions. Therefore, some lncRNAs and circRNAs can regulate several cell functions through modulating AKT and AKT effectors. This review provides insights into a comprehensive network of AKT and AKT effectors connecting to lncRNAs and circRNAs in the regulation of cancer cell functions.

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Emerging Roles of Circular RNAs in Vascular Smooth Muscle Cell Dysfunction

Cited by 6 publications

References 68 publications

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Review:Research status of cardiovascular and cerebrovascular diseases and non-coding RNA

Role of advanced glycation end products on vascular smooth muscle cells under diabetic atherosclerosis

Long Noncoding RNAs and Circular RNAs Regulate AKT and Its Effectors to Control Cell Functions of Cancer Cells

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