Circular RNA circNRIP1 plays oncogenic roles in the progression of osteosarcoma

Meng, Yibin; Hao, Dingjun; Huang, Yunfei; Jia, Shuaijun; Zhang, JiaNan; He, Xirui; Liu, Deyin; Sun, Liang

doi:10.1007/s00335-021-09891-3

Cited by 18 publications

(20 citation statements)

References 36 publications

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“…The expression level of circNRIP1 in OS tissues was significantly up-regulated, and the down-regulation of circNRIP1 could inhibit the proliferation and migration of OS (osteosarcoma) cells and promote cell apoptosis. A further bioassay showed [ 102 ] that circNRIP1 played a tumorigenic role in OS by sponging miR-199a. Further studies of such interactions ( Table 5 ) may bring us surprises.…”

Section: Resultsmentioning

confidence: 99%

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Wei

Chai

et al. 2022

IJMS

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Lung cancer is the leading cause of cancer death worldwide. miR-199a, which has two mature molecules: miR-199a-3p and miR-199a-5p, plays an important biological role in the genesis and development of tumors. We collected recent research results on lung cancer and miR-199a from Google Scholar and PubMed databases. The biological functions of miR-199a in lung cancer are reviewed in detail, and its potential roles in lung cancer diagnosis and treatment are discussed. With miR-199a as the core point and a divergence outward, the interplay between miR-199a and other ncRNAs is reviewed, and a regulatory network covering various cancers is depicted, which can help us to better understand the mechanism of cancer occurrence and provide a means for developing novel therapeutic strategies. In addition, the current methods of diagnosis and treatment of lung cancer are reviewed. Finally, a conclusion was drawn: miR-199a inhibits the development of lung cancer, especially by inhibiting the proliferation, infiltration, and migration of lung cancer cells, inhibiting tumor angiogenesis, increasing the apoptosis of lung cancer cells, and affecting the drug resistance of lung cancer cells. This review aims to provide new insights into lung cancer therapy and prevention.

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Section: Resultsmentioning

confidence: 99%

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Wei

Chai

et al. 2022

IJMS

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“…180 The mutual regulation between m6A and miRNA/circRNA/lncRNA is found in OS and is involved in the growth, migration, invasion of tumour cells, tumorigenesis and tumour progression. 34,37,181 The major mutual regulation mechanism between miRNA and m6A in OA is that m6A accel- closely associated with the prognosis of OS. 182 In summary, the ncRNA m6A modification plays vital roles in OS pathophysiology, and the indepth exploration of new m6A-related ncRNAs in OS may be a promising direction (Figure 4B and Table 2).…”

Section: Mutual Regulation Between M6a and Ncrna In Osmentioning

confidence: 99%

“…OS has a high degree of heterogeneity and significant genome complexity, and the pathophysiology remains unclear 180 . The mutual regulation between m6A and miRNA/circRNA/lncRNA is found in OS and is involved in the growth, migration, invasion of tumour cells, tumorigenesis and tumour progression 34,37,181 . The major mutual regulation mechanism between miRNA and m6A in OA is that m6A accelerates pri‐miRNA processing and maturation.…”

Section: Interplay Between M6a and Ncrna In Msdsmentioning

confidence: 99%

“…Meng et al detected that METTL3 and circNRIP1 are upregulated in OS cells/tissues, and circNRIP1 can promote forkhead box protein C2 (FOXC2) expression by sponging miRNA miR‐199a. METTL3 contributes to circNRIP1 m6A modification, promoting cell proliferation and apoptosis by the circNRIP1/miR‐199a/FOXC2 axis 37 . The regulatory mechanism between m6A and lncRNAs in OS is that m6A modification regulates the stability and degradation of lncRNA.…”

Section: Interplay Between M6a and Ncrna In Msdsmentioning

confidence: 99%

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Novel insights into the interaction between N6‐methyladenosine methylation and noncoding RNAs in musculoskeletal disorders

et al. 2022

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Background: Musculoskeletal disorder (MSD) are a class of inflammatory and degener-ative diseases, but the precise molecular mechanisms are still poorly understood. Noncoding RNA (ncRNA) N6-methyladenosine (m6A) modification plays an essential role in the pathophysiological process of MSD. This review summarized the interaction between m6A RNA methylation and ncRNAs in the molecular regulatory mechanism of MSD. It provides a new perspective for the pathophysiological mechanism and ncRNA m6A targeted therapy of MSD.Methods: A comprehensive search of databases was conducted with musculoskeletal disorders, noncoding RNA, N6-methyladenosine, intervertebral disc degeneration, osteoporosis, osteosarcoma, osteoarthritis, skeletal muscle, bone, and cartilage as the key-words. Then, summarized all the relevant articles.Results: Intervertebral disc degeneration (IDD), osteoporosis (OP), osteosarcoma (OS), and osteoarthritis (OA) are common MSDs that affect muscle, bone, cartilage, and joint, leading to limited movement, pain, and disability. However, the precise pathogenesis remains unclear, and no effective treatment and drug is available at present. Numerous studies confirmed that the mutual regulation between m6A and ncRNAs (i.e., microRNAs, long ncRNAs, and circular RNAs) was found in MSD, m6A modification can regulate ncRNAs, and ncRNAs can also target m6A regulators. ncRNA m6A modification plays an essential role in the pathophysiological process of MSDs by regulating the homeostasis of skeletal muscle, bone, and cartilage.Conclusion: m6A interacts with ncRNAs to regulate multiple biological processes and plays important roles in IDD, OP, OS, and OA. These studies provide new insights into the pathophysiological mechanism of MSD and targeting m6A-modified ncRNAs may be a promising therapy approach.

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“…Its expression was reportedly elevated by METTL3, a methyltransferase that induces m 6 A modification to circNRIP1. In turn, circNRIP1 sponges miR-199a to upregulate FOXC2 expression in OS [ 56 ]. Additionally, RNase L, activated upon viral infection, can degrade all types of circRNAs.…”

Section: Main Characteristics Of Circrnasmentioning

confidence: 99%

Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas

et al. 2021

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Circular RNAs (circRNAs) are single-stranded RNAs generated from exons back-splicing from a single pre-mRNA, forming covalently closed loop structures which lack 5′-3′-polarity or polyadenylated tail. Ongoing research depicts that circRNAs play a pivotal role in tumorigenesis, tumor progression, metastatic potential and chemoresistance by regulating transcription, microRNA (miRNA) sponging, RNA-binding protein interactions, alternative splicing and to a lesser degree, protein coding. Sarcomas are rare malignant tumors stemming from mesenchymal cells. Due to their clinically insidious onset, they often present at advanced stage and their treatment may require aggressive chemotherapeutic or surgical options. This review is mainly focused on the regulatory functions of circRNAs on osteosarcoma progression and their potential role as biomarkers, an area which has prompted lately extensive research. The attributed oncogenic role of circRNAs on other mesenchymal tumors such as Kaposi Sarcoma (KS), Rhabdomyosarcoma (RMS) or Gastrointestinal Stromal Tumors (GISTs) is also described. The involvement of circRNAs on sarcoma oncogenesis and relevant emerging diagnostic, prognostic and therapeutic applications are expected to gain more research interest in the future.

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Circular RNA circNRIP1 plays oncogenic roles in the progression of osteosarcoma

Cited by 18 publications

References 36 publications

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Novel insights into the interaction between N6‐methyladenosine methylation and noncoding RNAs in musculoskeletal disorders

Dissecting the Role of Circular RNAs in Sarcomas with Emphasis on Osteosarcomas

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