miR-199a: A Tumor Suppressor with Noncoding RNA Network and Therapeutic Candidate in Lung Cancer

Abstract

Lung cancer is the leading cause of cancer death worldwide. miR-199a, which has two mature molecules: miR-199a-3p and miR-199a-5p, plays an important biological role in the genesis and development of tumors. We collected recent research results on lung cancer and miR-199a from Google Scholar and PubMed databases. The biological functions of miR-199a in lung cancer are reviewed in detail, and its potential roles in lung cancer diagnosis and treatment are discussed. With miR-199a as the core point and a divergence outward, the interplay between miR-199a and other ncRNAs is reviewed, and a regulatory network covering various cancers is depicted, which can help us to better understand the mechanism of cancer occurrence and provide a means for developing novel therapeutic strategies. In addition, the current methods of diagnosis and treatment of lung cancer are reviewed. Finally, a conclusion was drawn: miR-199a inhibits the development of lung cancer, especially by inhibiting the proliferation, infiltration, and migration of lung cancer cells, inhibiting tumor angiogenesis, increasing the apoptosis of lung cancer cells, and affecting the drug resistance of lung cancer cells. This review aims to provide new insights into lung cancer therapy and prevention.

Sex disparities in non-small cell lung cancer: mechanistic insights from a cRaf transgenic disease model

“… 59 A further example relates to the 2-fold repressed tumour suppressor miR-199a-3p which targets ARG2 . 60 As described above, ARG2 is highly expressed in tumour associated macrophages and its induced expression is unique to cRaf females ( Supplementary Table S3 ).…”

Functional impact of multi-omic interactions in lung cancer

“…In the context of NSCLC, miR-199a has been found to be significantly downregulated compared to normal tissue. Previous studies have consistently reported miR-199a as a tumor suppressor in NSCLC, and its reduced expression has been attributed to methylation abnormalities ( Meng et al, 2022 ).…”

Identification of A Novel Cuproptosis-related lncRNAs for the Prognostic and Immune Landscape in Wilms Tumor

“…The numerous lncRNAs produced by human cells have signi cant roles in a number of biological processes, which include genome expression and cell differentiation [28]. Previous work has suggested that irregular lncRNAs expression may have a function in cancer development and evolution [29,30]. It is noteworthy that this is the rst full-scale work on the role of lncRNAs associated with Cuproptosis in WT.…”