Circular RNA CircHIPK3 Promotes Gemcitabine Sensitivity in Bladder Cancer

Xie, Fang; Zhao, Ning; Zhang, Hui; Xie, Dalong

doi:10.7150/jca.39722

Cited by 29 publications

(25 citation statements)

References 31 publications

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“… 13 In the meantime, circRNAs have been indicated to be dysregulated in multiple cancer tissues relative to matched normal tissues, especially in BC, signifying their role as diagnostic and prognostic biomarkers of BC. 14 , 15 In the present work, a new circRNA, circ_0000629, was found remarkably downregulated in BC tissues and cells. We further revealed that circ_0000629 served as a tumor suppressor and had the potency to suppress the proliferation and aggressiveness of BC cells in vitro and in vivo.…”

Section: Discussionsupporting

confidence: 56%

Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73

Wang

Luo

et al. 2021

CMAR

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Background Recent studies showed circular RNAs (circRNAs) played regulatory roles in bladder cancer (BC). However, the relevance of circ_0000629, a newly identified circRNA, has not been determined yet. We aimed to characterize the function of circ_0000629 in BC and the relevant mechanism. Methods First, we downloaded circRNA-related microarrays GSE147985 and GSE92675 from the GEO database, followed by a validation in our clinically obtained samples. We then overexpressed circ_0000629 in T24 and SW780 cells and evaluated the effects of circ_0000629 on BC cell proliferatory, apoptotic, and metastatic abilities. We further detected the subcellular localization of circ_0000629 in T24 and SW780 cells by the fractionation and export assay and FISH experiments. Integrated microarray analyses and bioinformatics website prediction were utilized to screen out the downstream microRNA (miRNA)/mRNA. The effects of miR-1290 and CDC73 on BC cell growth and metastasis was verified by functional rescue experiments. In addition, mice xenografts were built to measure the effect of circ_0000629 on tumor growth in vivo. Results Circ_0000629 and CDC73 were reduced, and miR-1290 was significantly overexpressed in BC tissues and cells. Moreover, circ_0000629 significantly inhibited the development and metastasis of BC cells, but further overexpression of miR-1290 or knockdown of CDC73 attenuated the inhibitory effect of circ_0000629 on BC cells. Circ_0000629 localized in the cytoplasm and regulated CDC73 expression by sponging miR-1290. Further, overexpressed circ_0000629 reduced the BC tumor growth in vivo. Conclusion Circ_0000629 promotes the expression of CDC73 by competitively binding to miR-1290, thereby inhibiting the growth and metastasis of BC cells.

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Section: Discussionsupporting

confidence: 56%

Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73

Wang

Luo

et al. 2021

CMAR

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“…circ-Foxo3 is derived from FOXO3 mRNA, and Cdr1as is formed by back-splicing of the cerebellar degeneration-related protein 1 gene ( 73 , 74 ). A different study illustrated that the overexpression of circHIPK3 has been shown to lead to an increased sensitization of BC cells to gemcitabine and act as a biomarker for DFS in patients with BC ( 75 ). In addition, the apoptosis and chemosensitivity of docetaxel in androgen-dependent PCa cells could be increased by the overexpression of circFoxo3.…”

Section: Circrnas Act As Therapeutic Targets For Bc Pca and Rccmentioning

confidence: 99%

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

Yang

Zou

et al. 2021

Mol Med Rep

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Circular RNAs (circRNAs) are a class of non-coding RNAs formed by covalently closed loops through back-splicing and exon-skipping. circRNAs have been confirmed to play a vital role in various biological functions, acting as microRNA sponges and reservoirs, as well as combining with RNA-binding proteins during the progression of multiple cancer types. Therefore, the present review evaluated recent research articles in PubMed that were published between November 2017 and September 2020. Key word search strings included: ‘Circular RNA (circRNA) AND bladder cancer (BC)’, ‘circular RNA (circRNA) AND prostate cancer (PCa)’ and ‘circular RNA (circRNA) AND renal cell cancer (RCC)’. In total, >58 circRNAs were found to be implicated in urological cancers, with several of the circRNAs targeting common carcinogenic pathways, such as the AKT, TGF-β, MAPK, VEGF and even metabolic pathways. circRNAs are important modulators of BC, PCa and RCC. circRNAs are functionally implicated in the pathogenesis of these cancer types, and have been found to act as biomarkers for the diagnosis and prognosis of urological cancer. However, to the best of our knowledge, the functions of circRNAs in tumors of the urinary system remain largely unknown and require further research.

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“…Furthermore, circHIPK3 plays a regulatory role in metastasis in hepatocellular carcinoma (HCC) and glioma by sponging miR-338-3p and miR-124-3p, respectively. Then it induces the upregualation of EMT-associated proteins E-cadherin, N-cadherin, vimentin, and ZEB2, thus promoting EMT [ 39 , 87 – 89 ].…”

Section: Cellular Effects Caused By Circhipk3mentioning

confidence: 99%

Biogenesis, cellular effects, and biomarker value of circHIPK3

Sun

2021

Cancer Cell Int

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Competing endogenous RNAs (ceRNAs) can indirectly regulate gene expression by competitively binding to microRNA(miRNA) through miRNA response elements (MREs) to affect miRNA-induced gene regulation, which is of great biological significance. Among them, circular RNA (circRNA) has become a hotspot due to its highest binding capacity. A specific circRNA discussed in this review, circHIPK3, has been studied for its biological characteristics, function, cellular effects and its relationship with tumors and various diseases. Here, we review the recent researches about circHIPK3 in detail and aim to elucidate accurate conclusions from them. These circHIPK3-miRNAs-mRNA pathways will further advance the application of circHIPK3 in diseases development, early diagnosis and gene targeting therapy.

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Circular RNA CircHIPK3 Promotes Gemcitabine Sensitivity in Bladder Cancer

Cited by 29 publications

References 31 publications

Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73

Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

Biogenesis, cellular effects, and biomarker value of circHIPK3

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