Circuitry of the Dorsal Lateral Geniculate Nucleus in the Cat and Monkey

Wilson, James R.

doi:10.1159/000147475

Cited by 52 publications

(40 citation statements)

References 35 publications

(43 reference statements)

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“…Although the properties of neurons in cat area 17 and macaque V1 are known to be similar Wiesel, 1962, 1968), we cannot be certain that all of the results will generalize across the species given the known differences in cortical architecture (Wilson and Cragg, 1967). A recent study examined the timing of responses in macaque V1 (Xing et al, 2005) and reported the existence of a fast untuned suppression even in the absence of a cross-orientation stimulus.…”

Section: Discussionmentioning

confidence: 96%

“…Allison et al (2001) suggested a possible extrastriate origin (area 18) for cross-orientation suppression based on its strength at high temporal frequencies. This hypothesis was based on their results from areas 17 and 18 in the cat, which both receive direct LGN input (Wilson and Cragg, 1967). In the macaque, however, area V2 does not receive a substantial input from the LGN.…”

Section: Discussionmentioning

confidence: 99%

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Dynamics of Suppression in Macaque Primary Visual Cortex

2006

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The response of a neuron in primary visual cortex (V1) to an optimal stimulus in its classical receptive field (CRF) can be reduced by the presence of an orthogonal mask, a phenomenon known as cross-orientation suppression. The presence of a parallel stimulus outside the CRF can have a similar effect, in this case known as surround suppression. We used a novel stimulus to probe the time course of cross-orientation suppression and found that it is very fast, starting even before the response to optimal excitatory stimuli. However, it occurs with some delay after the offset response, considered to be a measure of the earliest excitatory signals that reach the CRF. We also examined the time course of response to a stimulus presented outside the CRF and found that cross-orientation suppression begins substantially earlier than surround suppression measured in the same cells. Together, these findings suggest that cross-orientation suppression is attributable to either direct feedforward signal paths to V1 neurons or a circuit involving fast local interneurons within V1. Feedback from higher cortical areas is implicated in surround suppression, but our results make this an implausible mechanism for cross-orientation suppression. We conclude that suppression from inside and outside the CRF occur through different mechanisms.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Dynamics of Suppression in Macaque Primary Visual Cortex

2006

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“…This might best be conceived by considering a feedback influence on the difference of Gaussian model (Rodieck, 1965) for LGN cell receptive fields. The overlying feedback could provide a nonlinear modulatory enhancement of the excitatory Gaussian underpinning the classical receptive field by direct effects on the relay cells and the displaced feedback could provide a nonlinear modulatory enhancement of the inhibitory Gaussian underpinning the nonclassical surround by effects on intrinsic or TRN inhibitory neurons (Wilson, 1993;Cudeiro and Sillito, 2006;Jones, 2007;Briggs and Usrey, 2011). In this sense then the displaced feedback with inhibitory effect is driven by both stimuli that overly and extend beyond the center mechanism (as in Fig.…”

Section: Discussionmentioning

confidence: 97%

Differential Feedback Modulation of Center and Surround Mechanisms in Parvocellular Cells in the Visual Thalamus

et al. 2012

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Many cells in both the central visual system and other sensory systems exhibit a center surround organization in their receptive field, where the response to a centrally placed stimulus is modified when a surrounding area is also stimulated. This can follow from laterally directed connections in the local circuit at the level of the cell in question but could also involve more complex interactions. In the lateral geniculate nucleus (LGN), the cells relaying the retinal input display a concentric, center surround organization that in part follows from the similar organization characterizing the retinal cells providing their input. However, local thalamic inhibitory interneurons also play a role, and as we examine here, feedback from the visual cortex too. Here, we show in the primate (macaque) that spatially organized cortical feedback provides a clear and differential influence serving to enhance both responses to stimulation within the center of the receptive field and the ability of the nonclassical surround mechanism to attenuate this. In short, both center and surround mechanisms are influenced by the feedback. This dynamically sharpens the spatial focus of the receptive field and introduces nonlinearities from the cortical mechanism into the LGN.

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“…The LGN of cats has long been known to project widely to extrastriate cortex (for review, see Stone, 1983), but the severe retrograde degeneration and loss of neurons in the LGN after V1 lesions in primates (Weller et al, 1984) and the early use of less sensitive tracers (Wilson and Cragg, 1967;Garey and Powell, 1971;Hendrickson et al, 1978) led to the early assumption that LGN neurons project exclusively to V1. However, sensitive retrograde transport methods subsequently revealed that a few LGN neurons in monkeys do project to extrastriate cortex (Wong-Riley, 1976;Yukie and Iwai, 1981).…”

Section: Discussionmentioning

confidence: 99%

Thalamic connections of the dorsomedial visual area in primates

Beck

Kaas

1998

J. Comp. Neurol.

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The dorsomedial visual area (DM) of owl monkeys is a cortical area that has been described recently in a range of primate species. To study the thalamic connections of this area, injections of several distinguishable neuroanatomical tracers were placed into DM in galagos, owl monkeys, squirrel monkeys, and macaque monkeys. The distribution of label was remarkably consistent across these diverse primate species. Labeled connections were densest within the pulvinar complex. Both the lateral and inferior divisions of the pulvinar, but not the medial division, had connections with DM. Within the inferior pulvinar of monkeys, central lateral and central medial nuclei had dense connections, and the medial and posterior nuclei had sparse connections with DM. Sparser connections were revealed in the lateral geniculate nucleus and the nucleus limitans. Anterograde label was also found in the superior colliculus. The consistencies in the pattern of subcortical projections across prosimian primates, New World monkeys, and Old World monkeys support the concept that DM is a visual area common to all primates. In addition, these results provide further evidence for proposed subdivisions of the inferior pulvinar.

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Circuitry of the Dorsal Lateral Geniculate Nucleus in the Cat and Monkey

Cited by 52 publications

References 35 publications

Dynamics of Suppression in Macaque Primary Visual Cortex

Dynamics of Suppression in Macaque Primary Visual Cortex

Differential Feedback Modulation of Center and Surround Mechanisms in Parvocellular Cells in the Visual Thalamus

Thalamic connections of the dorsomedial visual area in primates

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