The degradation of CMOS devices over the lifetime can cause the severe threat to the system performance and reliability at deep submicron semiconductor technologies. The negative bias temperature instability (NBTI) is among the most important sources of the aging mechanisms. Applying the traditional guardbanding technique to address the decreased speed of devices is too costly. Due to the unbalanced duty cycle ratio of the SRAM cells, the instruction cache suffers a heavy NBTI stress and thus the aging effect will be further exacerbated. In this paper, we propose an aging-aware design to combat the NBTIinduced aging in the instruction cache. First, the detailed lifetime behaviors of the cachelines in the instruction cache are studied. Then, different schemes are proposed to mitigate the negative aging effects by balancing the duty cycle ratio of the SRAM cells in the cachelines according to their different lifetime phases. By applying our proposed idle-time-based cacheline invalidation and bit-flipping /complementing schemes, the duty cycle ratio of the instruction cache can be well balanced and the NBTI stress will be significantly reduced.