CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression

Chenglong, Zhang; Long, Tianyi; Bi, Sisi; Sheikh, Sayed Ali; Li, Fēi

doi:10.1038/s41374-020-00483-4

Cited by 33 publications

(14 citation statements)

References 47 publications

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“…Downregulation of Pink1 abrogated antiautophagy induced by circPAN3 overexpression in myocardial I/R injury. Therefore, circPAN3 provided protective role in the myocardial I/R injury via circPAN3-miR-421-Pink1 signaling axis-mediated autophagy [ 88 ]. Pretreatment with Salidroside, exhibiting protective effect on cardiovascular system, autophagy was prominently suppressed in myocardial I/R injury rat model, which was gently rescued by rapamycin (RAPA), an autophagic agonist, accompanied with the upregulation of circ-0000064.…”

Section: Ncrnas Regulate Autophagy In Myocardial I/r-injurymentioning

confidence: 99%

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Huang

Mai

Chen

et al. 2021

J Cardiothorac Surg

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The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete reperfusion via Percutaneous Coronary Intervention (PCI) or thrombolysis have distinctly decreased the mortality of myocardial infarction, reperfusion itself may lead to supererogatory irreversible myocardial injury and heart function disorders, namely ischemia-reperfusion (I/R) injury. Extensive studies have indicated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play important roles in the progress of myocardial I/R injury, which is closely correlative with cardiomyocytes autophagy. Moreover, autophagy plays an important role in maintaining homeostasis and protecting cells in the myocardial ischemia reperfusion and cardiomyocyte hypoxia-reoxygenation (H/R) progress. In this review, we first introduced the biogenesis and functions of ncRNAs, and subsequently summarized the roles and relevant molecular mechanisms of ncRNAs regulating autophagy in myocardial I/R injury. We hope that this review in addition to develop a better understanding of the physiological and pathological roles of ncRNAs, can also lay a foundation for the therapies of myocardial I/R injury, and even for other related cardiovascular diseases.

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Section: Ncrnas Regulate Autophagy In Myocardial I/r-injurymentioning

confidence: 99%

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Huang

Mai

Chen

et al. 2021

J Cardiothorac Surg

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“…MicroRNA-31-5p acts as a negative regulator of circPAN3 by directly suppressing QKI in doxorubicin-induced apoptosis of cardiomyocytes (117). circPAN3 also ameliorates myocardial ischemia and reperfusion injury by regulating miR-421/Pink1 axis-mediated suppression of autophagy (118). HECTD1 overexpression increases cell viability and decreases cell apoptosis and migration, and circDLPAG4/HECTD1 mediates ischemia/reperfusion injury in endothelial cells via ER stress (119).…”

Section: Circrna and Cvdsmentioning

confidence: 99%

Circular RNAs and Cardiovascular Regeneration

Tang

Jang

et al. 2021

Front. Cardiovasc. Med.

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circular RNAs (circRNAs) are a type of non-coding RNAs that are widely present in eukaryotic cells. They have the characteristics of stable structure, high abundance, and cell or tissue specific expression. circRNAs are single-stranded RNAs that are covalently back spliced to form closed circular loops. They may participate in gene expression and regulation through a variety of action modes. circRNAs can encode proteins or function by acting as miRNA sponges for protein translation. Since 2016, a growing number of research studies have shown that circRNAs play important role in the pathogenesis of cardiovascular disease. With the construction of circRNA database, the differential expression of circRNAs in the heart tissue samples from different species and the gradual elucidation of its mode of action in disease may become an ideal diagnosis biomarker and an effective therapeutic target. What can be expected surely has a broader application prospect. In this review, we summarize recent publications on circRNA biogenesis, expression profiles, functions, and the most recent studies of circRNAs in the field of cardiovascular diseases with special emphasis on cardiac regeneration.

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“…CircPAN3, a circRNA generated from the PAN3 locus, has been found to maintain the self-renewal of intestinal stem cells (126), to modulate drug resistance in acute myeloid leukemia (AML) (127,128), and to recede myocardial ischaemia/reperfusion injury (129). Recently, Li et al reported circPAN3 as a new profibrotic factor in cardiac fibrosis (84).…”

Section: Circrna_pan3mentioning

confidence: 99%

Circle the Cardiac Remodeling With circRNAs

Yang

Long

et al. 2021

Front. Cardiovasc. Med.

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Cardiac remodeling occurs after the heart is exposed to stress, which is manifested by pathological processes such as cardiomyocyte hypertrophy and apoptosis, dendritic cells activation and cytokine secretion, proliferation and activation of fibroblasts, and finally leads to heart failure. Circular RNAs (circRNAs) are recently recognized as a specific type of non-coding RNAs that are expressed in different species, in different stages of development, and in different pathological conditions. Growing evidences have implicated that circRNAs play important regulatory roles in the pathogenesis of a variety of cardiovascular diseases. In this review, we summarize the biological origin, characteristics, functional classification of circRNAs and their regulatory functions in cardiomyocytes, endothelial cells, fibroblasts, immune cells, and exosomes in the pathogenesis of cardiac remodeling.

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CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression

Cited by 33 publications

References 47 publications

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Circular RNAs and Cardiovascular Regeneration

Circle the Cardiac Remodeling With circRNAs

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