Circovirus-Like Infection in a Pigeon

Woods, Leslie W.; Latimer, Kenneth S.; Barr, Bradd C.; Niagro, Frank D.; Campagnoli, Raymond P.; Nordhausen, Robert W.; Castro, Anthony E.

doi:10.1177/104063879300500417

Cited by 85 publications

(66 citation statements)

References 10 publications

(3 reference statements)

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“…Circovirus infection in pigeons was first reported in the US in 1990 (Woods et al, 1993). The present report describes the first case of PiCV in France, which occurred in a loft of broiler pigeons in late 1998.…”

Section: Discussionmentioning

confidence: 65%

“…Pigeon circovirus infection (PiCV) is an emerging disease recognized for the first time in the US in California during the autumn of 1990 (Woods et al, 1993). A subsequent retrospective study demonstrated circovirus by transmission electron microscopy in tissues from pigeons that were recognized as having circovirus-like inclusions as early as 1986 in Canada and 1989 in Australia (Woods et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

“…Circoviruses are tiny non-enveloped icosahedral viruses (15-24 nm in diameter) with a single-stranded circular DNA of 1.76 kb to 2.31 kb (Bassami et al, 1998;Niagro et al, 1998). Like most other members of the newly proposed Circoviridae family, PiCV is characterized by typical basophilic globular inclusions in light microscopy (Woods et al, 1993;Shivaprasad et al, 1994;Woods et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Pigeon circovirus infection: Pathological observations and suggested pathogenesis

et al. 2001

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Pigeon circovirus infection (PiCV) was diagnosed by light and transmission electron microscopy in 15 birds from five lofts in western France. Histopathological findings were suggestive of primary bursotropism of pigeon circovirus, followed by secondary systemic spread from the bursa of Fabricius, particularly to non-bursal lymphoid organs. The last stage of the disease was associated with various secondary (particularly bacterial) infections. In situ detection of apoptosis in the bursa of Fabricius indicated that PiCV was concomitant with an increase in bursal lymphocytic apoptotic events related to viral infection and leading to severe acquired immunosuppression.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pigeon circovirus infection: Pathological observations and suggested pathogenesis

et al. 2001

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“…One of the characteristic histological features of circovirus infections of young birds is the occurrence of cytoplasmic globular or botryoid inclusions, which are commonly found in mononuclear inflammatory cells in the bursa of Fabricius. The most studied avian viruses of the circovirus genus are BFDV, which causes feather and beak abnormalities in a wide range of psittacine birds, and PiCV, infections with which are associated with a variety of clinical signs including lethargy, weight loss, respiratory distress, diarrhoea and poor race performance (Woods et al ., 1993;Shivaprasad et al ., 1994). Infections with BFDV and PiCV are both associated with lymphoid depletion and immunosuppression, which appears to increase the severity of secondary infections.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of novel circoviruses from finch and gull

et al. 2007

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The purpose of this study was to molecularly characterize circoviruses that infect finches and gulls. Circovirus-specific DNAs were isolated using polymerase chain reaction methods from bursa of Fabricius tissues from a Gouldian finch (Chloebia gouldiae) and a herring gull (Larus argentatus) that were known to be circovirus-infected. Nucleotide sequence determination and analysis of cloned genomic DNAs showed that these circoviruses represented novel members of the genus Circovirus of the family Circoviridae, and have been tentatively named Finch circovirus (FiCV) and Gull Circovirus (GuCV). Both new circoviruses shared genome organizational features with previously characterized circoviruses, such that both contained two major, inversely-arranged open reading frames encoding the putative replication-associated and capsid proteins, and both contained a potential stemÁloop and nonanucleotide motif. Phylogenetic analyses based on genome nucleotide sequences and involving the seven additional genus members indicated that FiCV and GuCV were more closely related to canary circovirus, beak and feather disease virus and pigeon circovirus, and that FiCV and canary circovirus were the most closely related avian circoviruses. Pairwise comparisons showed that the capsid proteins of FiCV and GuCV shared highest amino acid identity values with those of canary circovirus (62.0%) and pigeon circovirus (40.6%), respectively. The 5? intergenic region of GuCV was longer (207 nucleotides) and contained more direct and inverse repeated sequences than those of other circoviruses, while the 3? intergenic region of FiCV was notable in being longer (307 nucleotides) than its counterparts in other circoviruses and in containing two long repeats of 77 nucleotides.

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“…In 1993, the ® rst report of a circovirus-like infection in a pigeon (Columbiformes) was published (Woods et al, 1993). Further circovirus-like infections in pigeons have subsequently been identi® ed in the US, as well as in Australia, Canada, Northern Ireland and England (Woods et al, 1994;Shivaprasad et al, 1994;Smyth & Carroll, 1995;Smyth, 1995;Gough & Drury, 1996).…”

Section: Introductionmentioning

confidence: 99%

Circovirus-like infection in a southern black-backed gull (Larus dominicanus)

Twentyman¹,

Alley²,

Meers³

et al. 1999

Avian Pathology

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A juvenile black-backed gull (Larus dominicanus) from the Manawatu region of New Zealand was found to have chronic airsacculitis due to Aspergillus spp. Histologically, there was moderately severe in¯ammation in the bursa of Fabricius associated with large, basophilic, intracytoplasmic inclusions, which ultrastructurally had an appearance typical of circovirus inclusions. This ® nding suggests that circoviruses may be more widespread in avian species than previously recognized and may be responsible for diseases associated with immunosuppression in free-living birds.

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Circovirus-Like Infection in a Pigeon

Cited by 85 publications

References 10 publications

Pigeon circovirus infection: Pathological observations and suggested pathogenesis

Pigeon circovirus infection: Pathological observations and suggested pathogenesis

Molecular characterization of novel circoviruses from finch and gull

Circovirus-like infection in a southern black-backed gull (Larus dominicanus)

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