CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1

Zhang, Ming-xiao; Wang, Jiali; Mo, Chengqiang; Mao, Xiaopeng; Lin, Haishan; Song, Hongde; Xu, Quanhui; Wang, Yinghan; Lü, Jun; Wei, Jinhuan; Han, Hui; Chen, Wei; Mao, Haiping; Luo, Junhang; Chen, Zhenhua

doi:10.1038/s41388-022-02386-8

Cited by 24 publications

(14 citation statements)

References 39 publications

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“…It is promising to be a new prognostic indicator and a promising therapeutic target. CircME1 interacts with U1 snRNP to upregulate ME1 expression and thereby promote resistance to sunitinib in renal cancer cells [ 201 ]. The study suggests that circME1 may be a promising biomarker for predicting sunitinib resistance and a therapeutic target for ccRCC.…”

Section: Circrnas Are Potential Diagnostic and Prognostic Biomarkers ...mentioning

confidence: 99%

The function and mechanisms of action of circular RNAs in Urologic Cancer

et al. 2023

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Kidney, bladder, and prostate cancer are the three major tumor types of the urologic system that seriously threaten human health. Circular RNAs (CircRNAs), special non-coding RNAs with a stabile structure and a unique back-splicing loop-forming ability, have received recent scientific attention. CircRNAs are widely distributed within the body, with important biologic functions such as sponges for microRNAs, as RNA binding proteins, and as templates for regulation of transcription and protein translation. The abnormal expression of circRNAs in vivo is significantly associated with the development of urologic tumors. CircRNAs have now emerged as potential biomarkers for the diagnosis and prognosis of urologic tumors, as well as targets for the development of new therapies. Although we have gained a better understanding of circRNA, there are still many questions to be answered. In this review, we summarize the properties of circRNAs and detail their function, focusing on the effects of circRNA on proliferation, metastasis, apoptosis, metabolism, and drug resistance in kidney, bladder, and prostate cancers.

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Section: Circrnas Are Potential Diagnostic and Prognostic Biomarkers ...mentioning

confidence: 99%

The function and mechanisms of action of circular RNAs in Urologic Cancer

et al. 2023

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“…Recent studies have reported the role of circRNA in ccRCC. For example, Gui et al ( 27 ) reported that circCHST15 promotes ccRCC cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis, Zhang et al ( 28 ) proposed the circME1/ME1 pathway as involved in ccRCC progression and sunitinib resistance development ( 29 ) and Wang et al ( 29 ) presented circDVL1 as exerting a tumor-suppressive function during ccRCC progression through the circDVL1/miR-412-3p/PCDH7 axis. The upregulation of circWWC3 expression was observed in ccRCC tissues in the present study, and patients with high circWWC3 expression levels exhibited worse overall survival OS times.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma

Wang

et al. 2023

Oncol Lett

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The aim of the present study was to assess the prognostic value of circular RNA WW and C2 domain-containing protein 3 (circWWC3) in patients with clear cell renal cell carcinoma (ccRCC). The clinicopathological data were collected for patients with ccRCC treated between January 1, 2012, and February 31, 2014, at The Fourth Hospital of Hebei Medical University Hospital (Shijiazhuang, China). A total of 150 patients who underwent nephrectomy were included in the study. Analysis of stored tissues and long-term follow-up data was performed. Fluorescence in situ hybridization was used to detect the relative circWWC3 expression in fresh-frozen cancerous and adjacent para-cancerous tissue samples from patients with ccRCC. A χ 2 test was used to analyze the association between circWWC3 expression levels and the clinicopathological parameters of the patients. A Cox proportional risk regression model was used to analyze the clinical factors affecting patient prognosis. The survival curve was plotted using the Kaplan-Meier method, and the association between circWWC3 expression levels and patient survival status was tested using the log-rank test. circWWC3 expression in cancerous tissues was higher than that in the adjacent normal tissues. Additionally, circWWC3 expression was significantly associated with T stage (P= 0.005) and pathological grade (P= 0.033). Univariate Cox regression analysis showed that overall survival (OS) was associated with T stage, pathological Fuhrman grade and circWWC3 expression levels (all P<0.05). Multivariate Cox regression analysis also yielded similar results in patients with ccRCC (P<0.05). Moreover, the OS time of patients with high circWWC3 expression was significantly shorter than that of patients with low circWWC3 expression. In conclusion, high circWWC3 expression is an independent risk factor affecting patient prognosis, and is expected to be an important prognostic biomarker and novel therapeutic target for patients with ccRCC.

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“…EIciRNAs such as CircEIF3J and CircPAIP2, which are also present in the nucleus, bind to the U-small ribonucleoprotein and then to pol II to similarly regulate gene expression (18). Additionally, many studies have shown that ciRNAs and EIciRNAs may have cisregulatory effects on the transcription of the coding gene (19).…”

Section: Transcriptional Regulationmentioning

confidence: 99%

Regulatory mechanism of circular RNA involvement in osteoarthritis

Zhang

Liu

et al. 2023

Front. Surg.

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Osteoarthritis (OA) causes joint pain, stiffness, and dysfunction in middle-aged and older adults; however, its pathogenesis remains unclear. Circular RNAs (circRNAs) are differentially expressed in patients with OA and participate in a multigene, multitarget regulatory network. CircRNAs are involved in the development of OA through inflammatory responses, including proliferation, apoptosis, autophagy, differentiation, oxidative stress, and mechanical stress. Most circRNAs are used as intracellular miRNA sponges in chondrocytes, endplate chondrocytes, mesenchymal stem cells, synoviocytes, and macrophages to promote the progression of OA. However, a small portion of circRNAs participates in the pathogenesis of OA by intracellular mechanisms, such as protein binding, methylation, or intercellular exosome pathways. In this sense, circRNAs might serve as potential novel biomarkers and therapeutic targets for OA.

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CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1

Cited by 24 publications

References 39 publications

The function and mechanisms of action of circular RNAs in Urologic Cancer

The function and mechanisms of action of circular RNAs in Urologic Cancer

Prognostic value of circWWC3 as a novel survival‑related biomarker for clear cell renal cell carcinoma

Regulatory mechanism of circular RNA involvement in osteoarthritis

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