Regulatory mechanism of circular RNA involvement in osteoarthritis

Zhang, Yuke; Liu, Liting; Li, Kai; Wang, Meiying; Su, Xiulan; Wang, Jianzhong

doi:10.3389/fsurg.2022.1049513

Cited by 8 publications

(4 citation statements)

References 81 publications

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“…Cao et al engineered human umbilical cord MSC (hucMSC)-exosomes with a two-phase microgel targeting chondrocytes; the hucMSC-exosomes rejuvenated OA chondrocytes ( Cao et al, 2023 ). Others have reported similar findings ( Zhang et al, 2022 ; Pang et al, 2023 ), suggesting that combinations of novel biomaterials and MSC-exosomes have potential as cell-free therapeutics for OA.…”

Section: Introductionsupporting

confidence: 55%

Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases

Yang,

Zhang,

et al. 2024

Front. Mol. Biosci.

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Skeletal diseases impose a considerable burden on society. The clinical and tissue-engineering therapies applied to alleviate such diseases frequently result in complications and are inadequately effective. Research has shifted from conventional therapies based on mesenchymal stem cells (MSCs) to exosomes derived from MSCs. Exosomes are natural nanocarriers of endogenous DNA, RNA, proteins, and lipids and have a low immune clearance rate and good barrier penetration and allow targeted delivery of therapeutics. MSC-derived exosomes (MSC-exosomes) have the characteristics of both MSCs and exosomes, and so they can have both immunosuppressive and tissue-regenerative effects. Despite advances in our knowledge of MSC-exosomes, their regulatory mechanisms and functionalities are unclear. Here we review the therapeutic potential of MSC-exosomes for skeletal diseases.

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Section: Introductionsupporting

confidence: 55%

Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases

Yang,

Zhang,

et al. 2024

Front. Mol. Biosci.

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“…CircRNAs, characterized by their unique closed-loop structure, offer exceptional stability and are involved in gene regulation by interacting with microRNAs or other molecular entities. [357][358][359] This interaction often results in the "sponge effect", where circR-NAs inhibit microRNA activity, thereby modulating the expression of genes pertinent to OA. [360][361][362] This regulatory mechanism plays a crucial role in controlling inflammatory responses, facilitating chondrocyte metabolism, and aiding in the repair processes of damaged tissues.…”

Section: Other Non-coding Rnamentioning

confidence: 99%

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Yang,

Zhang

2024

Adv Funct Materials

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Osteoarthritis (OA), a prevalent joint disease affecting many people globally, presents significant challenge in current treatments, which often only manage symptoms without halting disease progression. This review illuminates novel approaches in OA therapy, focusing mainly on intra‐articular injection of nanomaterials. The innovative materials, designed to either mimic or augment natural joint lubrication, show promise in restoring joint biomechanics and alleviating pain. The review delves into an array of biomimetic lubricants, including polymer brush, nanocomposite hydrogel, and nanoparticles, underscoring their roles in anti‐inflammation, targeting, cartilage repair, and drug delivery. Furthermore, the potential of mesenchymal stem cells to differentiate into chondrocytes, coupled with the delivery of these cells and their exosomes via nanomaterials, has promoted cell therapy avenues for OA. The review also highlights the function of non‐coding RNAs such as miRNA, siRNA, circRNA, lncRNA, and antisense oligonucleotides in impeding OA progression, with nanomaterials facilitating their delivery, thus facilitating advanced therapeutic possibilities including immune evasion and bone cell proliferation. Overall, this review encapsulates the evolution of nanomaterials in OA treatment from material to cell, and ultimately to gene therapy, forecasting a future where nanomaterials evolve toward integrated, personalized diagnostics and therapeutics for OA.

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“…circRNAs seem to participate in OA by combining mechanisms of oxidative and mechanical stress, autophagy, proliferation, and apoptosis. Zhang et al recently published an excellent and comprehensive review on circRNAs in OA [61].…”

Section: Circrnasmentioning

confidence: 99%

Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions

Michelacci

Baccarin²,

Rodrigues³

2023

Life

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Chondrocytes are the main cell type in articular cartilage. They are embedded in an avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are responsible for the synthesis and turnover of the ECM, in which the major macromolecular components are collagen, proteoglycans, and non-collagen proteins. The crosstalk between chondrocytes and the ECM plays several relevant roles in the regulation of cell phenotype. Chondrocytes live in an avascular environment in healthy cartilage with a low oxygen supply. Although chondrocytes are adapted to anaerobic conditions, many of their metabolic functions are oxygen-dependent, and most cartilage oxygen is supplied by the synovial fluid. This review focuses on the transcription control and signaling responsible for chondrocyte differentiation, homeostasis, senescence, and cell death and the changes that occur in osteoarthritis. The effects of chondroitin sulfate and other molecules as anti-inflammatory agents are also approached and analyzed.

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Regulatory mechanism of circular RNA involvement in osteoarthritis

Cited by 8 publications

References 81 publications

Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases

Therapeutic potential of mesenchymal stem cell-derived exosomes in skeletal diseases

Intra‐Articular Injection of Nanomaterials for the Treatment of Osteoarthritis: From Lubrication Function Restoration to Cell and Gene Therapy

Chondrocyte Homeostasis and Differentiation: Transcriptional Control and Signaling in Healthy and Osteoarthritic Conditions

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