CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer

Guo, Ruiting; Cui, Xueying; Li, Xue; Wen, Zhiyuan; Chang, Mingjie; Sun, Zenghui; Liu, Zhifang; Sun, Yuan; Jia, Jihui; Li, Wenjuan

doi:10.1038/s41419-022-04811-y

Cited by 22 publications

(17 citation statements)

References 37 publications

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“…Using high-throughput RNA-seq, Guo et al (2022a) analyzed circRNA expression profiles in PBS-treated and Helicobacter pylori-infected AGS cells. As compared to the control, among 18,308 different circRNA candidates, the experiment yielded 101 significantly differentially expressed circRNAs, including 84 upregulated and 17 downregulated circRNAs.…”

Section: Circrnas In Gastric Cancermentioning

confidence: 99%

Circular RNAs as diagnostic biomarkers for gastric cancer: A comprehensive update from emerging functions to clinical significances

Zeng²,

Xu³

et al. 2022

Front. Genet.

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The incidence and mortality of gastric cancer ranks as a fouth leading cause of cancer death worldwide, especially in East Asia. Due to the lack of specific early-stage symptoms, the majority of patients in most developing nations are diagnosed at an advanced stage. Therefore, it is urgent to find more sensitive and reliable biomarkers for gastric cancer screening and diagnosis. Circular RNAs (circRNAs), a novel type of RNAs with covalently closed loops, are becoming a latest hot spot in the field of. In recent years, a great deal of research has demonstrated that abnormal expression of circRNAs was associated with the development of gastric cancer, and suggested that circRNA might serve as a potential biomarker for gastric cancer diagnosis. In this review, we summarize the structural characteristics, formation mechanism and biological function of circRNAs, and elucidate research progress and existing problems in early screening of gastric cancer.

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Section: Circrnas In Gastric Cancermentioning

confidence: 99%

Circular RNAs as diagnostic biomarkers for gastric cancer: A comprehensive update from emerging functions to clinical significances

Zeng²,

Xu³

et al. 2022

Front. Genet.

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“…Additionally, H. pylori can upregulate circMAN1A2 expression in GC cells, and circMAN1A2 may promote proliferation, migration and invasion of H. pylori-induced GC by sponging miR-1236-3p to increase MTA2 expression (99).…”

Section: Circrnas and Helicobacter Pylori-related Gastric Cancermentioning

confidence: 99%

“…Earlier studies also confirmed that circFNDC3B could mediate GC cell migration and invasion by promoting epithelial-mesenchymal transition (EMT) ( 98 ). Additionally, H. pylori can upregulate circMAN1A2 expression in GC cells, and circMAN1A2 may promote proliferation, migration and invasion of H. pylori -induced GC by sponging miR-1236-3p to increase MTA2 expression ( 99 ).…”

Section: Circrnas and Helicobacter Pylori -Related...mentioning

confidence: 99%

The role of non-coding RNA in the diagnosis and treatment of Helicobacter pylori-related gastric cancer, with a focus on inflammation and immune response

et al. 2022

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Helicobacter pylori (H. pylori) is one of the globally recognized causative factors of gastric cancer (GC). Currently, no definite therapy and drugs for H. pylori-related GC have been widely acknowledged although H. pylori infection could be eradicated in early stage. Inflammation and immune response are spontaneous essential stages during H. pylori infection. H pylori may mediate immune escape by affecting inflammation and immune response, leading to gastric carcinogenesis. As an important component of transcriptome, non-coding RNAs (ncRNAs) have been proven to play crucial roles in the genesis and development of H. pylori-induced GC. This review briefly described the effects of ncRNAs on H. pylori-related GC from the perspective of inflammation and immune response, as well as their association with inflammatory reaction and immune microenvironment. We aim to explore the potential of ncRNAs as markers for the early diagnosis, prognosis, and treatment of H. pylori-related GC. The ncRNAs involved in H. pylori-related GC may all hold promise as novel therapeutic targets for immunotherapy.

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“…found that the downregulated expression of circEIF4G3 was observed in GC and was associated with poor clinical outcomes ( 25 ). Another study showed that circMAN1A2 could regulate MTA2 through sponging miR-1236-3p, promoting the progression of H. pylori-induced GC ( 26 ). These above studies give us a hint that the value of circRNAs in GC remains to be further clarified.…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer

Liu

Ding

et al. 2022

Front. Oncol.

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ObjectiveAt present, there are still no effective diagnosis methods for gastric cancer (GC). Increasing evidences indicate that Extracellular Vesicle circular RNAs (EV circRNAs) play a crucial role in several diseases. However, their correlations with GC are not clarified. This study aims to investigate the expression profile of serum EV circRNAs in GC and evaluate its potential clinical value.MethodsHigh-throughput RNA sequencing (RNA-seq) was used to assess circRNA expression profiles between 4 patients with GC and 4 healthy controls. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were employed to determine the biological functions of differentially expressed (DE) circRNAs. A circRNA-miRNA-mRNA network was constructed using bioinformatics tools. Reverse transcription-quantitative polymerase chain reaction (RT-q)PCR was used to validate the dysregulated circRNAs. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic value of circRNAs for GC.ResultsA total of 4692 circRNAs were detected in the serum EVs of healthy controls and patients with GC, most of which were novel (98%) and intergenic (52%). 7 circRNAs were upregulated and 4 circRNAs were downregulated (|log2Fold Change| > 2, P < 0.05). GO and KEGG pathway enrichment analyses revealed that DE circRNAs were primarily involved in glutathione metabolism, protein folding, and drug metabolism-cytochrome P450. Of these, 3 circRNAs (Chr10q11, Chr1p11, and Chr7q11) were identified to be significantly overexpressed in patients with GC compared with healthy controls using RT-qPCR. The combination of 3 EV circRNAs and carcinoembryonic antigen (CEA) produced an area under the curve (AUC) of 0.866 (95%CI: 0.803-0.915) with a sensitivity and specificity of 80.4% and 81.8%, respectively. Additionally, the expression levels of 3 EV circRNAs were significantly correlated with tumor size, lymph node metastasis, and TNM stage. The circRNA-miRNA-mRNA network showed that the 3 identified circRNAs were predicted to interact with 13 miRNAs and 91 mRNAs.ConclusionOur results illustrate that the panel of EV circRNAs in serum are aberrantly expressed and may act as the suitable biomarkers for gastric cancer.

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CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer

Cited by 22 publications

References 37 publications

Circular RNAs as diagnostic biomarkers for gastric cancer: A comprehensive update from emerging functions to clinical significances

Circular RNAs as diagnostic biomarkers for gastric cancer: A comprehensive update from emerging functions to clinical significances

The role of non-coding RNA in the diagnosis and treatment of Helicobacter pylori-related gastric cancer, with a focus on inflammation and immune response

Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer

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