CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis

Huang, Changshan; Yu, Wei; Wang, Qian; Huang, Tao; Ding, Yanqiao

doi:10.2147/jhc.s317256

Cited by 21 publications

(18 citation statements)

References 33 publications

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“…ROC curves were used to examine their diagnostic values, and they found the AUCs to be 0.888, 0.76, 0.816, and 0.8692, respectively. These results suggest that exosomal circRNAs are diagnostic biomarkers for HCC ( 42 , 45 , 46 , 48 ). Furthermore, Chen et al.…”

Section: The Diagnostic and Prognostic Values Of Exosomal Circrnas In...mentioning

confidence: 76%

“…Huang et al. ( 42 ) found that MiR-532-5p could be sponged by circANTXR1 and XRCC5 was a target of miR-532-5p. They indicated circANTXR1 silencing can inhibit HCC cell progression in vitro and suppress HCC tumor growth in vivo through the miR-532-5p/XRCC5 axis.…”

Section: The Biological Functions Of Exosomal Circrnas In Hccmentioning

confidence: 99%

“…In another study, the expressions of exosomal circ-0072088, circANTXR1, circTMEM45A, hsa_circ_0061395, and hsa_circ_0004001 were significantly upregulated in patients with HCC and positively correlated with TNM stages and tumor size but not with gender or age. In addition, the expression of circTMEM45A was also related to vascular invasion ( 40 , 42 , 45 , 47 , 56 ). Furthermore, high levels of hsa_circ_0004123 and hsa_circ_0075792 expression were positively correlated with tumor size and the TNM stages, but not with age, gender, and LNM ( 56 ).…”

Section: Relationships Between Exosomal Circrnas and Clinicopathologi...mentioning

confidence: 99%

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The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

Zhao

Yao

2022

Front. Oncol.

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Hepatocellular carcinoma (HCC) exacts a heavy disease burden and is currently the second most common cause of cancer-related deaths worldwide. HCC usually lacks obvious symptoms in the early stage, and most HCC patients are diagnosed at advanced stages with poor prognosis. Circular RNAs (circRNAs) are single-stranded RNAs that form covalently closed loops and are stable in exosomes. Exosomes are known as important messengers of the cross-talk between tumor and immune cells. Accumulating studies have demonstrated the promoter or suppressor roles of exosomal circRNAs in the carcinogenesis, progression, and metastasis of HCC. In this review, we summarized the current studies on the biological functions and diagnostic and prognostic values of exosomal circRNAs in HCC progression.

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Section: The Diagnostic and Prognostic Values Of Exosomal Circrnas In...mentioning

confidence: 76%

Section: The Biological Functions Of Exosomal Circrnas In Hccmentioning

confidence: 99%

Section: Relationships Between Exosomal Circrnas and Clinicopathologi...mentioning

confidence: 99%

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The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

Zhao

Yao

2022

Front. Oncol.

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“…Based on the results 0f qRT-PCR analysis,we constructed a novel circRNA-related ceRNA network containing 4 circRNAs, 17miRNA and 136mRNAs.Recently,since it has beenfound abnormality expressed in many tumors and closely related to invasion, metastasis and prognosis of the malignancy, miR-214-3p,miR-532-5p and miR-432 might be regarded as a clinical biomarker and therapeutic target [28][29][30].A foreign study [31] showed that there is a similar molecular mechanism between the embryo implantation and cancer metastasis in many mammals, including human, involving cell proliferation and apoptosis, immune avoidance and angiogenesis stimulation.In combination with the signaling pathways involved in the above biological analysis,we suspected that circRNAs whose host genes may affect endometrial receptivity by regulating the capabilities of proliferation,apoptosis,migration and permeability of endometriam.…”

Section: Discussionmentioning

confidence: 99%

The Identification And Functional Analysis Of Circrnas In Endometrial Receptivity Of Mice With Polycystic Ovary Syndrome

Zhao

Wang

et al. 2022

Preprint

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Background: The disorders of endometrial receptivity and ovulatory dysfunction are both important causes of infertility of patients with Polycystic Ovary Syndrome(PCOS) .The study aimed to investigate the expression profile and functional analysis of circRNAs in the endometrial receptivity of mice with PCOS. Methods: Twenty-four 4-week-old female C57BL/6 mice were randomly divided into two groups(PCOS group and Normal control group,n=12) and PCOS group was subcutaneously with DHEA 6mg/kg for 20 days.The circRNA expression profile in the endometrium tissue of two groups on the 4th day of gestation was screened by gene chip technique.Bioinformatics analyses, including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were performed to preliminary understand the functions of circRNAs. The expression of selected circRNA was verified by RT-PCR and and circRNA–microRNA(miRNA)–messenger RNA (mRNA) negative correlation network analyses was construct by Cytoscape.Result: Compared with mice in NC group,there are 205 differentially expressed circRNAs significantly in mice of PCOS group,including 147 up-regulated and 58 down-regulated circRNAs(fold change [FC]≥1.5 and p value < 0.05). GO analysis demonstrated that the host genes of differentially regulated circRNAs were mainly related to protein binding,cellular process and cellular anatomical entity.KEGG analysis revealed that these source genes were engaged in the Proteoglycans in cancer,Cell junctions (focal adheren and gap junction) ,Pathways in cancer,Ras signaling pathway,Chemokine signaling pathway，autophagy and PI3K-Akt signaling pathway.qRT-PCR results showed that the expression levels of circRNA_38548 (P<0.05), circRNA_001686(P<0.05) and circRNA_38550(P<0.01) in PCOS group were significantly higher than those in normal group,while the expression level of circRNA_27938 in PCOS group was significantly lower than that in control group (P<0.05). The expression of circRNA_29710 (P=0.051) and circRNA_34429 (P=0.892) showed no significant difference between the two groups.We used target prediction software(TargetScan and miRanda) to predict the target genes of circRNA_38548, circRNA_001686, circRNA_38550 and circRNA_27938.The circRNA-miRNA-mRNA regulatory network diagram was constructed using Cytoscape software,involving 4 circRNAs (circRNA_38548, circRNA_38550, circRNA_001686, circRNA_27938) and 17miRNAs (miR-214-3p,miR-532-5p and miR-432,etc.) and 136mRNAs(Lifr, FOXK1, FOXO1, HOXA10, etc.). Conclusions: The circRNAs were aberrantly expressed in the implantation window of PCOS mice,suggesting that differentially expressed circRNA may play a role in the endometrial receptivity of PCOS. We validated four circRNAs(circRNA_38548, circRNA_38550, circRNA_001686 and circRNA_27938),which may contribute to the abnormal endometrial receptivity of PCOS by regulating the expression of Lifr, FOXK1, FOXO1, HOXA10 and other genes through targeting mir-214-3p, mir-532-5p, mir-423 and other miRNAs. These four circRNAs are worthy targets for further study of the related mechanisms.

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“…Huang C et al. found that exosome-mediated the intercellular transmission of circANTXR1 in HCC cells ( 75 ). Overexpressed exosomal circANTXR1 could depress miR-532-5p expression and promote XRCC5 mRNA and protein expression, promoting the proliferation, migration and invasion of HCCLM3 cells.…”

Section: Circrnas and Exosomesmentioning

confidence: 99%

Circular RNAs and Their Role in Exosomes

Han

Chen²,

Guo

et al. 2022

Front. Oncol.

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As a novel class of endogenous non-coding RNAs discovered in recent years, circular RNAs (circRNAs) are highly conserved and stable covalently closed ring structures with no 5′-end cap or 3′-end poly(A) tail. CircRNAs are formed by reverse splicing, mainly by means of a noose structure or intron complementary pairing. Exosomes are tiny discoid vesicles with a diameter of 40-100 nm that are secreted by cells under physiological and pathological conditions. Exosomes play an important role in cell-cell communication by carrying DNA, microRNAs, mRNAs, proteins and circRNAs. In this review, we summarize the biological functions of circRNAs and exosomes, and further reveal the potential roles of exosomal circRNAs in different diseases, providing a scientific basis for the diagnosis, treatment, and prognosis of a wide variety of diseases.

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CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis

Cited by 21 publications

References 33 publications

The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

The Biological Functions and Clinical Values of Exosomal Circular RNAs in Hepatocellular Carcinoma

The Identification And Functional Analysis Of Circrnas In Endometrial Receptivity Of Mice With Polycystic Ovary Syndrome

Circular RNAs and Their Role in Exosomes

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