Circannual rhythm in natural killer activity and mitogen responsiveness of murine splenocytes

Pati, Atanu Kumar; Florentin, I.; Chung, V.; Sousa, Martine De; Lévi, Françis; Mathé, G

doi:10.1016/0008-8749(87)90207-3

Cited by 35 publications

(11 citation statements)

References 15 publications

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“…Similar results have been observed in the ground squirrel (13). Reproducible circannual rhythms have also been found for [3][4][5] consecutive yr for the in vivo migration of polymorphonuclear cells (14) and for the splenic natural killer (NK)' cell activity (15) in mice kept in a standard photoperiodic environment. Immune functions are also organized along a circadian time structure, as documented in preceding articles by us (16,17) and by others (18)(19)(20)(21)(22).…”

Section: Introductionsupporting

confidence: 72%

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

Lévi

Canon²,

Touitou³

et al. 1988

J. Clin. Invest.

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Section: Introductionsupporting

confidence: 72%

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

Lévi

Canon²,

Touitou³

et al. 1988

J. Clin. Invest.

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“…Nieman et al [11] noted a 35% decrease in NCMC from September to November, the same time frame as this study, and emphasized the importance of controlling for circannual variations [11]. Other authors have reported similar circannual variations [36,37]. The fact that NCMC did not change with the onset of the winter season in exercisers may indicate that endurance training attenuated the seasonal or circannual effect.…”

Section: Discussionsupporting

confidence: 54%

Effects of Endurance Training on Selected Parameters of Immune Function in Elderly Women

et al. 2000

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Background: Immune function decreases with age, rendering the elderly more susceptible to infection and tumor development. In addition, intense exercise has been shown to decrease immune function in some populations. Few studies have examined the effects of exercise on immune function in the elderly and, to our knowledge, no studies have examined the effects of exercise on a population of active, but nonexercising elderly. Objective: The purpose of this study was to examine the effects of a 10-week endurance training program on selected parameters of immune function in active elderly women. Methods: A total of 29 healthy, active women, aged 70–87, were randomly assigned to either an exercise (76 ± 5 years, n = 15) or control (77 ± 6 years, n = 14) group. The exercise group walked 3 days/week at 70% heart rate reserve (HRR). The duration on day 1 was 20 min and it was increased by 5 min each day until subjects were walking for 50 min (week 3). It remained at 50 min for the duration of the study, while controls maintained normal activity. Blood samples were obtained from both groups at rest, and from the exercise group after 20 min of walking at 70% HRR and after 2 h of recovery. Blood samples were collected prior to endurance training and again after 10 weeks of endurance training. Results: There was a significant decrease in 1-mile walk times as well as heart rate at completion of the walk in the exercise group. Natural cell-mediated cytotoxicity (NCMC) was significantly higher post-exercise, compared to pre-exercise both before and after training. After training it remained significantly elevated 2 h post-exercise. The resting NCMC was significantly decreased in controls at week 10 but not in the exercise group. Conclusion: Ten weeks of endurance training resulted in a significant decrease in both the 1-mile walk time and the post-walk heart rate in the exercisers but not the controls, without resulting in either an acute or chronic suppression of immune function. Further, endurance training may lead to an attenuation of the decrease in cellular immune measures which occurs during the winter, since the control group experienced a decrease in NCMC and the exercisers did not.

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“…2, 3), in agreement with others (Brock 1987;Pati et al 1987). As with seasonal changes in leukocyte concentration, the changes in CD25 expression may be due to seasonal variations in cortisol, melatonin and prolactin production (Brock 1987;Maes et al 1997), and suggest that March-April is a period of reduced lymphocyte responsiveness and proliferation, while August-September and January are periods of increased lymphocyte responsiveness.…”

Section: Discussionsupporting

confidence: 81%

“…As with seasonal changes in leukocyte concentration, the changes in CD25 expression may be due to seasonal variations in cortisol, melatonin and prolactin production (Brock 1987;Maes et al 1997), and suggest that March-April is a period of reduced lymphocyte responsiveness and proliferation, while August-September and January are periods of increased lymphocyte responsiveness. Others have also reported an increase in PHA lymphocyte proliferative responses from September to November (Pati et al 1987), and deWnite seasonal variations in both T and NK cell function (Brock 1987;Maes et al 1994). In our study, the seasonal changes occurred regardless of training status, and may be of clinical interest in that there may be certain months of the year where older individuals have reduced lymphocyte antigenic/mitogenic responsiveness and proliferation (Maes et al 1994;Mann et al 2000;Neckers and Cossman 1983).…”

Section: Discussionmentioning

confidence: 49%

Aerobic training increases the stimulated percentage of CD4+CD25+ in older men but not older women

Broadbent

Gass

2008

Eur J Appl Physiol

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The purpose of the present study was to determine whether 12 months of moderate intensity cycling would increase the expression of IL-2 (CD25+) receptors in T helper (CD4+) lymphocytes in men and women aged 65-75 years. Fourteen men and 10 women completed 52 weeks of moderate intensity cycling (60% VO2peak). Subjects trained (TR) three times per week for 45 min per session. Eight age-matched untrained (UT) male and eight UT female subjects acted as controls. Resting blood samples were taken from TR and UT subjects every 4 weeks. Leukocyte concentration was measured using a full blood count. PHA-stimulated CD4+ lymphocytes were analysed for changes in the expression of CD25+, by flow cytometry. Training significantly increased VO2peak (l min(-1), ml kg(-1) min(-1)) in male (+14.3, +16%) and female (+16.7, +27.8%) groups. The TR male group showed a significantly lower percentage of CD4+CD25+ than the male UT in January but the TR male percentage was significantly higher than the UT male group during February, March, April, May, June, September B and December. The female TR group showed a significantly higher percentage CD4+CD25+ than the female UT only during July. There were also significant sequential monthly changes in the percentage of CD4+CD25+ for male and female UT and TR groups. Significant increases in the percentage of CD4+CD25+ in the male TR group suggest training-enhanced lymphocyte mitogenic responsiveness. Moderate intensity long-term training may increase the recruitment of active memory CD4+CD25+ in men rather than women.

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Circannual rhythm in natural killer activity and mitogen responsiveness of murine splenocytes

Cited by 35 publications

References 15 publications

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

Effects of Endurance Training on Selected Parameters of Immune Function in Elderly Women

Aerobic training increases the stimulated percentage of CD4+CD25+ in older men but not older women

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