Circadian, weekly, and seasonal variation at the onset of acute aortic dissection

Circadian Proteomics and Its Unique Advantage for Discovery of Biomarkers of Heart Disease

“…The incidence of myocardial infarction in humans peaks in the morning (~6:00A.M.-12:00 noon) (Cohen et al, 1997;Goldberg et al, 1990;Muller et al, 1985). A similar pattern is observed in the incidences of sudden cardiac death (Muller et al, 1989;Willich et al, 1987), ventricular tachyarrhythmia (Eksik et al, 2007;Tofler et al, 1995), and rupture of aortic aneurysms (Manfredini et al, 2004;Mehta et al, 2002;Sumiyoshi et al, 2002). Precursor risk factors such as vasomotor tone, platelet aggregability, and other factors involved in thrombosis or thrombolysis also exhibit daily rhythms (Andrews et al, 1996;Angleton et al, 1989;Decousus et al, 1985;Maemura et al, 2000;Otto et al, 2004).…”

Circadian rhythm and cardiovascular disorders

“…It was first reported in two retrospective Italian studies 62,63 of acute rupture of thoracic aortic aneurysm and abdominal aortic aneurysm, respectively, which identified a primary peak at 10 am and a secondary peak at 8 pm. Subsequent studies worldwide have come to the same conclusion; 8,[64][65][66][67] in particular, a large study by Mehta et al 8 evaluated 957 patients enrolled in the International Registry of Acute Aortic Dissection (IRAD) between 1996 and 2000 and found a significantly higher frequency of acute aortic dissection between 6 am and noon in the entire data set as well as in an analysis of subgroups according to age, sex, type of dissection, and BP. This interesting observation suggests that the underlying mechanism is independent of these factors, including BP, which was thought to be the driving factor for the diurnal variation of adverse cardiovascular events.…”

Guidelines for Diagnosis and Treatment of Aortic Aneurysm and Aortic Dissection (JCS 2011)

“…[18][19][20] In terms of time, aortic aneurysm occurs more frequently in the daytime, i.e., when people are active; the onset is reported to be particularly frequent during the period of 6:00 to 12:00. Conversely, the onset is rare from late at night until early in the morning.…”