Circadian rhythm and cardiovascular disorders

Zhang, Lilei; Sabeh, Mohamed Khaled; Jain, Mukesh K.

doi:10.2147/cpt.s44805

Cited by 5 publications

(3 citation statements)

References 153 publications

(174 reference statements)

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“…The classic example of chronic circadian disruption is shift working. Early observations showed that shift workers have higher-than-average incidence of adverse cardiovascular events, including myocardial infarction, strokes, and sudden cardiac death (76)(77)(78)(79)(80)(81), with a predilection for events occurring in the early morning hours. While behavior changes associated with shift working (and not the disruption of circadian clock per se) may also have contributed, it is of particular interest that the exposure time to shift working showed a linear correlation with the load of cardiac diseases (82).…”

Section: R E V I E W S E R I E S : C I R C a D I A N R H Y T H Mmentioning

confidence: 99%

Circadian regulation of cardiac metabolism

Zhang¹,

Jain²

2021

Journal of Clinical Investigation

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Section: R E V I E W S E R I E S : C I R C a D I A N R H Y T H Mmentioning

confidence: 99%

Circadian regulation of cardiac metabolism

Zhang¹,

Jain²

2021

Journal of Clinical Investigation

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“…CLOCK and ARNTL (BMAL1) heterodimers form a positive loop that stimulates PER and CRY transcription and other clock-linked genes. A negative feedback loop is composed of PER and CRY heterodimers, which inhibits the transcription of CLOCK and ARNTL genes [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Škrlec

Talapko

Juzbašić

et al. 2021

JCDD

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The growing body of evidence shows a significant difference in the circadian rhythm of cardiovascular disease based on biological sex. The incidence of cardiovascular disease varies between women and men. Additionally, biological sex is vital for the timely application of therapy—chronotherapy, which benefits both sexes. This study aimed to examine the potential difference of single nucleotide polymorphisms (SNPs) of the circadian rhythm genes ARNTL, CLOCK, CRY2 and PER2 in women and men with myocardial infarction. A cross-sectional study was conducted, including 200 patients with myocardial infarction. Altogether, ten single nucleotide polymorphisms in the ARNTL, CLOCK, CRY2 and PER2 genes were analyzed. The Chi-square test yielded statistically significant differences in CLOCK gene rs11932595 polymorphism in a recessive genotype model between women and men with a p-value of 0.03 and an odds ratio 2.66, and a corresponding 95% confidence interval of 1.07 to 6.66. Other analyzed polymorphisms of the circadian rhythm genes ARNTL, CRY2, and PER2 did not significantly differ between the sexes. According to the study’s current results, the CLOCK gene’s genetic variability might affect myocardial infarction concerning biological sex.

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“…Cardiovascular Effects: (David Salisbury, 2013;Jain, Zhang, & Sabeh, 2014) Each cell involved in the cardiovascular system have their own molecular clocks which should be coordinated with the central clock for synchronized response of the body to diurnal variations in their environment.…”

Section: Introductionmentioning

confidence: 99%

Shift works impact on health outcomes of a non hazardousindustrial employees

2020

Sleep.Hypn

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Working time is the period of time that a person spends at paid labour. For every shift our body needs to adopt to the external changes. This may cause dreadful disruption of circadian rhythm which maintains all the biological responses including sleep-wake cycle, hormone inductioninhibition, hunger, growth and other cellular processes. Hence preventing the disruption of the circadian rhythm can prevent the disturbances in biological responses. The specific objectives include numerating the working pattern of general and shifting workers. To compare food habits, incidence of various health effects such as Cardiovascular risks, Sleep wake disorders, Endocrinological disorders (Diabetes, Cholesterol), Obesity, BMI, Blood Pressure among general and shift workers. An observational prospective study was carried out by approaching the workers, by a standard questionnaire which was designed to collect the data of the employees from the company and data was analyzed using statistical software. The observed values have shown that out of 302 workers general workers were 112 and shift workers were 190 and P-value <0.001 which is found to be significant. This study shows that the diabetic status, sleep disorders, appetite and GERD disturbances of the workers are dependent on the shift pattern being followed by them. There was a significant difference between shift and general workers in terms of Glucose levels, Blood Pressure, Total Cholesterol levels and GIT disturbances. Conclusion of our study revealed that prople working in shifts tend to have higher risk of prevalence of disorders such as Hypertension (Blood Pressure compared), Diabetes (Random Blood Sugar compared), Sleep and GIT disturbances. Body Mass Index, Total cholesterol levels of both general and shift workers did not show any high significance when compared. The risk of metabolic disorders was higher among those working in shift work rather than in the general workers.

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Circadian rhythm and cardiovascular disorders

Cited by 5 publications

References 153 publications

Circadian regulation of cardiac metabolism

Circadian regulation of cardiac metabolism

Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility

Shift works impact on health outcomes of a non hazardousindustrial employees

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