Circadian Variations in the Number of Actively Secreting Sebaceous Follicles and Androgen Circadian Rhythms

Abstract

Sebum excretion has been shown to demonstrate a circadian rhythm using a gravimetric method (cigarette paper). With the newly introduced method of Sebutape, we confirmed this periodicity and showed that the elevation in sebum excretion is correlated with an increase in the number of secreting follicles. We found, furthermore, that the number of secreting follicles on the forehead showed a distinct and statistically significant circadian rhythmicity, in contrast to those of the chest, which remained almost constant. The quantification in plasma levels of cortisol, melatonin, delta-4-androstenedione, dehydroepiandrosterone sulphate, and free testosterone showed no correlation with sebum excretion at either site. These observations suggest that local factors are involved in control of sebum secretion.

The Physiological and Psychological Effects of Windows, Daylight, and View at Home: Review and Research Agenda

“…The familiar daily activity cycle of sleeping and waking is the most obvious circadian rhythm, but many physiological systems show daily rhythms, including the cardiovascular and metabolic systems (Rüger & Scheer, 2009), immune system (Lange, Dimitrov, & Born, 2010; Brainard, Hanifin, et al (2001), and one dotted line, Thapan et al(2001) Roberts, 2000), and skin (Verschoore, Poncet, Krebs, & Ortonne, 1993). Each of these systems depends on the rhythm of light and dark to maintain the necessary pattern of physiological processes to maintain physical and mental health.…”

Chronophysiologie circadienne du cuir chevelu

“…L'excrétion de sébum est le paramètre qui a été le plus fré-quemment retrouvé être soumis à un biorythme au niveau du visage [17,19,20,25,26]. Nous retrouvons un débit instantané de sébum qui est similaire au niveau du cuir chevelu.…”

“…L'existence d'un rythme circadien de la PIE sur le visage et sur les avant-bras reste débattue [18,20,25,26,34]. Dans notre étude sur le cuir chevelu, il apparaît que le biorythme circadien de la PIE avait une ampleur importante, quoique inférieure à celle de l'excrétion instantanée du sébum.…”

“…La température cutanée, l'intensité de la sudation, le flux de sébum et le pH de la couche cornée sont eux aussi soumis à des fluctuations au cours du nycthémère [17][18][19][20][21][22][23][24][25][26]. Dans tous les cas, ces rythmes ne sont pas directement influencés par la lumière.…”

Circadian rhythm in atopic dermatitis—Pathophysiology and implications for chronotherapy

“…Facial sebum production oscillates in 8-and 24-hour patterns 3 and is highest in early afternoon and lowest at night. 7 Low nocturnal sebum production contributes to nighttime pruritus as sebum forms a hydrolipid film on the skin surface to maintain hydration. On a cellular level, circadian CLOCK genes regulate skin hydration.…”