Circadian rhythm in atopic dermatitis—Pathophysiology and implications for chronotherapy

Vaughn, Alexandra R.; Clark, Ashley K.; Sivamani, Raja K; Shi, Vivian Y.

doi:10.1111/pde.13364

Cited by 32 publications

(30 citation statements)

References 35 publications

(77 reference statements)

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“…67 Skin physiology parameters such as TEWL and cutaneous blood flow fluctuate with circadian rhythm. 67 Skin physiology parameters such as TEWL and cutaneous blood flow fluctuate with circadian rhythm.…”

Section: The Relationship Among Keratinocytes Nervous System and mentioning

confidence: 99%

“…Circadian rhythm is a biological clock that controls physiological functions throughout the body. 67 Skin physiology parameters such as TEWL and cutaneous blood flow fluctuate with circadian rhythm. 67 AD often exacerbates at night, and this phenomenon is related to increased TEWL at nighttime.…”

Section: The Relationship Among Keratinocytes Nervous System and mentioning

confidence: 99%

“…67 Skin physiology parameters such as TEWL and cutaneous blood flow fluctuate with circadian rhythm. 67 AD often exacerbates at night, and this phenomenon is related to increased TEWL at nighttime. 17 Melatonin is a hormone mainly secreted by pineal gland that regulates the circadian rhythm and sleep.…”

Section: The Relationship Among Keratinocytes Nervous System and mentioning

confidence: 99%

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Immune mediators and therapies for pruritus in atopic dermatitis and psoriasis

Zhou

et al. 2019

J Cutaneous Imm & Allergy

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractAtopic dermatitis (AD) and psoriasis (Pso) are two common inflammatory skin diseases which are symptomatically characterized by pruritus to variable degrees.Whereas AD is nearly always associated with pruritus, only 50%-70% of patients with Pso suffer from itching. Within the last decade, the development of biologic agents targeting specific cytokines or cytokine receptors has led to tremendous progress in suppressing inflammation (and thus improving quality of life) in these two diseases.While suppressing inflammation would generally reduce pruritus in these inflammatory diseases, pruritus is still recalcitrant for treatment in some patients due to relative lack of therapeutics that specifically inhibit pruritus signaling. There is abundant evidence that certain cytokines and neuropeptides-ion channels signaling mediate pruritus that is independent of inflammation in AD and psoriasis. Of note, Janus kinase (JAK) and nerve growth factor (NGF)-tropomyosin receptor kinase A (TrkA)transient receptor potential vanilloid 1 (TRPV1) signaling partially regulates pruritus in AD and psoriasis. JAK kinases inhibitors decrease the extent of itch in patients with AD and psoriasis. In clinical trials, topical inhibitors of TrkA and TRPV1 have been reported to reduce pruritus in patients with Pso and AD, respectively. In this article, we review recent literature knowledge regarding the mechanisms underlying pruritus in AD and Pso, providing hypotheses for why pruritus may be more common in AD than in Pso. In light of the different mechanisms underlying these two diseases, the current and developing therapeutics, either in human clinical trials or animal studies, for targeting pruritus are also discussed. K E Y W O R D SIL-31, neuropeptide, PAR2, SP, thymic stromal lymphopoietin, TRPA1, TRPV1

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Section: The Relationship Among Keratinocytes Nervous System and mentioning

confidence: 99%

Section: The Relationship Among Keratinocytes Nervous System and mentioning

confidence: 99%

Section: The Relationship Among Keratinocytes Nervous System and mentioning

confidence: 99%

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Immune mediators and therapies for pruritus in atopic dermatitis and psoriasis

Zhou

et al. 2019

J Cutaneous Imm & Allergy

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“…The circadian rhythm itself is a biological clock that controls a number of physiological functions throughout the body, including various skin functions 60 . At the same time, skin cells express circadian "clock" genes, such as CLOCK (circadian locomotor output cycles coat), BMAL1 (brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1), and Per1-3, which have autoregulatory feedback loops and maintain the rhythm of oscillating gene products.…”

Section: Proach To Skin Diseasesmentioning

confidence: 99%

“…Circadian rythms of cytokines, the immune system and skin physiology (e.g. transepidermal water loss and blood flow to the skin) can also play an important role 60 . There are data suggesting that atopic dermatitis is associated with attention deficit hyperactivity disorder, emotional and behavioral problems and delayed growth, which is thought to be associated with disturbed sleep.…”

Section: Proach To Skin Diseasesmentioning

confidence: 99%

Psychoneuroimmunology and skin diseases

Mihić¹,

Mihatović²,

Šitum³

2019

Rad Hrvatske akademije znanosti i umjetnosti

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Psychoneuroimmunology has emerged as a broad interdisciplinary field examining the interaction between the psychological state, the nervous system, the endocrine system, and the immune system. Psychodermatology or psychocutaneous medicine is an intersection of psychiatry, psychology and dermatology. There is a growing awareness of the connection between psychosocial stress and somatic illnesses, including dermatological diseases. Psychosomatic factors are considered significant in more than a third of people suffering from skin diseases. Communication between the psyche and the skin is a complex interaction of psychological, immunologic and endocrine factors with the skin, involving a number of neuropeptides, interleukins and immune system mediators. The skin, being the largest organ of the body, is equipped with metabolic and endocrinological capacities that facilitate homeostatic control between internal and external environments. In addition to psychosocial stress, factors relevant for a psychoneuroimmunological approach to skin diseases include nutrition, gut and skin microbiota, sleep and circadian rhythm, physical activity, and orthomolecular medicine. Knowledge of psychoneuroimmunological mechanisms and factors relevant for a holistic approach is very important for a better and broader understanding of skin diseases, and for better therapeutic outcomes for patients. Sažetak:Psihoneuroimunologija se pojavila kao široko interdisciplinarno područje koje obuhvaća povezanost psihičkog stanja, živčanog sustava, endokrinološkog sustava i imunološkog sustava. Psihodermatologija ili psihokutana medicina područje je ispreplitanja psihijatrije, psihologije i dermatologije. Sve je veći broj spoznaja koja govore o vezi psihosocijalnog stresa i somatskih bolesti, uključujući dermatološke bolesti. Psihosomatski čimbenici smatraju se značajnima u više od trećine osoba oboljelih od kožnih bolesti. Komunikacija između psihe i kože uključuje složene interakcije između psiholoških, imunoloških i endokrinoloških čimbenika sa kožnim sustavom, u čemu sudjeluje niz stvorenih neuropeptida, interleukina i posrednika imunološkog sustava. Pritom je koža, kao najveći organ tijela, opremljena metaboličkim i endokrinološkim sposobnostima koje olakšavaju homeostatsku kontrolu između unutarnjih i vanjskih okruženja. Uz psihosocijalni stresa, čimbenici važni unutar psihoneuroimunološkog pristupa kožnim bolestima uključuju prehranu, mikrobiom crijeva i kože, spavanje i cirkadijalni ritam, fizičku aktivnost i ortomolekularnu medicinu. Poznavanje psihoneuroimunoloških mehanizama i čimbenika relevantnih za holistički pristup vrlo je važno zbog boljeg razumijevanje kožnih bolesti, a ujedno i za bolji terapijski ishod u bolesnika. ključne riječi: psihoneuroimunologija, psihodermatologija, kožne bolesti, stres, psorijaza, atopijski dermatitis OPEN ACCESS

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The circadian clock and diseases of the skin

et al. 2021

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Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and adapt to daily changes in the environment. Synchronized to the light-dark cycle with a period of around 24 hours, the timing of the circadian clock is set by light-triggering signals sent from the retina to the suprachiasmatic nucleus. Other inputs, including food intake, exercise, and temperature, also affect clocks in peripheral tissues, including skin. Here, we review the intricate interplay between the core clock network and fundamental physiological processes in skin such as homeostasis, regeneration, and immune-and stress responses. We illustrate the effect of feeding time on the skin circadian clock and skin functions, a previously overlooked area of research. We then discuss works that relate the circadian clock and its disruption to skin diseases, including skin cancer, sunburn, hair loss, aging, infections, inflammatory skin diseases, and wound healing. Finally, we highlight the promise of circadian medicine for skin disease prevention and management.

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Circadian rhythm in atopic dermatitis—Pathophysiology and implications for chronotherapy

Cited by 32 publications

References 35 publications

Immune mediators and therapies for pruritus in atopic dermatitis and psoriasis

Immune mediators and therapies for pruritus in atopic dermatitis and psoriasis

Psychoneuroimmunology and skin diseases

The circadian clock and diseases of the skin

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