Circadian variation of the cell proliferation in the jejunal epithelium of rats at weaning phase

Gomes, José Rosa; Pereira, A. A. M.; Barth, L; Silva, J. S.; Leite, Maria Léa Corrêa; Wille, Ana Carolina Martins; Soares, M. A. M.

doi:10.1111/j.1365-2184.2005.00339.x

Cited by 11 publications

(12 citation statements)

References 20 publications

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“…This finding could be associated with the introduction of the light/dark cycle during weaning, after the eyes open at around the 14th day after birth. This hypothesis was confirmed in our previous study (Gomes et al,2005), in which it was observed that intestinal epithelial cells show a metaphase index (MI) peak at 15:00 hr during the weaning phase, but the acrophase of MI occurred during the dark period from 21:00 hr to 01:00 hr. This result demonstrated that there is already a circadian variation of the MI at the weaning phase that is influenced by the light/dark cycle.…”

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confidence: 83%

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Effects of Fasting at Different Stages of Lighting Regimen on the Proliferation of Jejunal Epithelial Cells During Rat Pup Weaning

Soares

Okada

Ayub

et al. 2009

The Anatomical Record

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The lifespan of intestinal epithelial cells is predetermined by the process of cell proliferation that occurs constantly in the crypt. The control of this process involves some endogenous factors, such as hormones, as well as exogenous factors, like food and natural light variations. These last two exogenous factors seem to be the major modulators of the cell proliferation process. Fasting treatment was conducted to assess the role of food and its effect on the metaphase index (MI) of the intestinal epithelium at different times and periods (light and dark) of the day. The effects of short-(5 hr) and long-term (25 hr) fasting on the MI in the jejunal epithelium of young rats were investigated at 09:00 h, 15:00 hr, 21:00 hr, and 02:00 hr using the arrested metaphases method. The present study demonstrates that 5 hr and 25 hr of fasting treatment decrease the MI at 09:00 hr. It was observed from MI analysis that there is an interaction between the fed/fasted status of the animal and the different times of the day. This result suggests that during the transition from youth to adulthood, the control of MI by the light/dark cycle seems to be more pronounced as compared with control by food intake at some periods of the day, although at other times food had a greater impact on the MI. Anat Rec, 292:955-959, 2009. V V C 2009 Wiley-Liss, Inc.

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confidence: 83%

“…Nevertheless, Gomes et al (2005) observed that a circadian variation in the rate of cell proliferation is already present in the jejunal epithelium of rats during the weaning phase. The authors demonstrated that the MI was lower in the morning than in other periods of the day, using the crypt squash method.…”

Section: Discussionmentioning

confidence: 99%

Effects of Fasting at Different Stages of Lighting Regimen on the Proliferation of Jejunal Epithelial Cells During Rat Pup Weaning

Soares

Okada

Ayub

et al. 2009

The Anatomical Record

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“…This would be possible if the loss of a few cells from the villi is compensated by a concomitant increase in cell proliferation into the crypts. As such, cell migration to the crypt villus junction may have led to the increased villus thickness observed, as the small intestine is an organ that undergoes physiological adaptation according to the diet during its growth, altering cell proliferation, migration and circadian rhythm (Gomes and Alvares, ; Wille et al, ; Gomes et al, ; Soares et al, ). In addition, we suggest that the reduction in goblet cell numbers, caused by physical exercise, may also be related to a change in microbiota in the small intestine that could differ between states of obesity and exercise; however, the hypothesis that physical exercise may change the microbiota of the small intestine needs to be further explored.…”

Section: Discussionmentioning

confidence: 99%

Effects of Physical Exercise on the Intestinal Mucosa of Rats Submitted to a Hypothalamic Obesity Condition

Gomes

Freitas

Grassiolli

2016

The Anatomical Record

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The small intestine plays a role in obesity as well as in satiation. However, the effect of physical exercise on the morphology and function of the small intestine during obesity has not been reported to date. This study aimed to evaluate the effects of physical exercise on morphological aspects of the rat small intestine during hypothalamic monosodium glutamate (MSG)-induced obesity. The rats were divided into four groups: Sedentary (S), Monosodium Glutamate (MSG), Exercised (E), and Exercised Monosodium Glutamate (EMSG). The MSG and EMSG groups received a daily injection of monosodium glutamate (4 g/kg) during the 5 first days after birth. The S and E groups were considered as control groups and received injections of saline. At weaning, at 21 days after birth, the EMSG and E groups were submitted to swimming practice 3 times a week until the 90th day, when all groups were sacrificed and the parameters studied recorded. Exercise significantly reduced fat deposits and the Lee Index in MSG-treated animals, and also reduced the thickness of the intestinal wall, the number of goblet cells and intestinal alkaline phosphatase activity. However, physical activity alone increased the thickness and height of villi, and the depth of the crypts. In conclusion, regular physical exercise may alter the morphology or/and functions of the small intestine, reducing the prejudicial effects of hypothalamic obesity. Anat Rec, 299:1389-1396, 2016. © 2016 Wiley Periodicals, Inc.

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“…Consistently, the circadian clocks from cyanobacteria to mammals are well-known to gate the different stages of the cell cycle, and thus impose temporal regulation to its progression. In mammals, for instance, S-phase and mitotic index in the oral mucosa, corneal epithelium, digestive tract and even bone marrow exhibit circadian fluctuations [52][53][54][55][56]. In a striking example of cell cycle gating by the clock, the timing of M-phase entry following partial hepatectomy is dictated by the time of day of the procedure [57].…”

Section: The Circadian Clock Cell Cycle Regulation and Dna Damage Rementioning

confidence: 99%

Relevance of Circadian Rhythm in Cancer

DiTacchio

Panda

2015

Energy Balance and Cancer

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Circadian rhythms are patterns of behavior, physiology, and metabolism that occur within a period of approximately 24 h. These rhythms are generated endogenously, but synchronize to external cues, thus enabling organisms to beneficially align physiological processes to the inherently dynamic, yet predictable, seasonal changes in the day-night cycle. The cell autonomous circadian oscillator temporally coordinates cellular processes, including metabolism, proliferation, cell signaling, organelle function, proteostasis, and DNA damage repair to sustain cellular homeostasis. It is hypothesized that the circadian oscillators evolved as a "flight from light" mechanism to minimize UV damage to single stranded DNA by restricting DNA replication to the nighttime. Support for this hypothesis is accumulating with the recent observation that the circadian rhythm and cell cycle are intimately coupled to each other, so that specific phases of cell cycle occur at a defined phase of the circadian oscillator at single-cell level [1]. Furthermore, chronic circadian disruption perturbs cellular homeostasis and predisposes to cancer. Conversely, numerous cancer cell lines display severe circadian alterations, which likely contribute to aggressive proliferation of the tumor. Hence, it is becoming increasingly important to understand the relevance of circadian rhythm for optimizing fitness

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Circadian variation of the cell proliferation in the jejunal epithelium of rats at weaning phase

Cited by 11 publications

References 20 publications

Effects of Fasting at Different Stages of Lighting Regimen on the Proliferation of Jejunal Epithelial Cells During Rat Pup Weaning

Effects of Fasting at Different Stages of Lighting Regimen on the Proliferation of Jejunal Epithelial Cells During Rat Pup Weaning

Effects of Physical Exercise on the Intestinal Mucosa of Rats Submitted to a Hypothalamic Obesity Condition

Relevance of Circadian Rhythm in Cancer

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