Circadian Variation of Migraine Attack Onset: A Review of Clinical Studies

Baksa, Dániel; Gecse, Kinga; Kumar, S.; Tóth, Zsuzsanna; Gál, Zsófia; Gonda, Xénia; Juhász, Gabriella

doi:10.1155/2019/4616417

Cited by 18 publications

(17 citation statements)

References 51 publications

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“…The pathological mechanism underlying the association between migraine and insomnia is not yet fully understood. According to most of the available studies, migraine attack onset follows a circadian variation, with an early morning or late-night peak of migraine attack onset [ 54 ]. The observed circadian pattern of migraine attack onset may be related to a temporal relationship with rapid eye movement (REM) sleep stages.…”

Section: Insomniamentioning

confidence: 99%

Migraine and sleep disorders: a systematic review

et al. 2020

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Migraine and sleep disorders are common and often burdensome chronic conditions with a high prevalence in the general population, and with considerable socio-economic impact and costs. The existence of a relationship between migraine and sleep disorders has been recognized from centuries by clinicians and epidemiological studies. Nevertheless, the exact nature of this association, the underlying mechanisms and interactions are complex and not completely understood. Recent biochemical and functional imaging studies identified central nervous system structures and neurotransmitters involved in the pathophysiology of migraine and also important for the regulation of normal sleep architecture, suggesting a possible causative role, in the pathogenesis of both disorders, of a dysregulation in these common nervous system pathways. This systematic review summarizes the existing data on migraine and sleep disorders with the aim to evaluate the existence of a causal relationship and to assess the presence of influencing factors. The identification of specific sleep disorders associated with migraine should induce clinicians to systematically assess their presence in migraine patients and to adopt combined treatment strategies.

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Section: Insomniamentioning

confidence: 99%

Migraine and sleep disorders: a systematic review

et al. 2020

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“…Symptoms from a part of the nervous system also follow circadian modulation. Migraine attacks and mood worsening in patients suffering from major depressive disorder occur predominantly in the morning; however, afternoon and evening episodes are also reported (26)(27)(28). Exacerbation of behavioral symptoms, socalled sundowning, in some of Alzheimer disease patients takes place during the afternoon and in the evening and is related to a phase delay of the body temperature rhythm (29)(30)(31).…”

Section: Circadian Rhythms In Diseasementioning

confidence: 99%

Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy

Smyk

Luijtelaar

2020

Front. Neurol.

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Many physiological processes such as sleep, hormonal secretion, or thermoregulation, are expressed as daily rhythms orchestrated by the circadian timing system. A powerful internal clock mechanism ensures proper synchronization of vital functions within an organism on the one hand, and between the organism and the external environment on the other. Some of the pathological processes developing in the brain and body are subjected to circadian modulation as well. Epilepsy is one of the conditions which symptoms often worsen at a very specific time of a day. Variation in peak occurrence depends on the syndrome and localization of the epileptic focus. Moreover, the timing of some types of seizures is closely related to the sleep-wake cycle, one of the most prominent circadian rhythms. This review focuses on childhood absence epilepsy (CAE), a genetic generalized epilepsy syndrome, in which both, the circadian and sleep influences play a significant role in manifestation of symptoms. Human and animal studies report rhythmical occurrence of spike-wave discharges (SWDs), an EEG hallmark of CAE. The endogenous nature of the SWDs rhythm has been confirmed experimentally in a genetic animal model of the disease, rats of the WAG/Rij strain. Well-known detrimental effects of circadian misalignment were demonstrated to impact the severity of ongoing epileptic activity. SWDs are vigilance-dependent in both humans and animal models, occurring most frequently during passive behavioral states and light slow-wave sleep. The relationship with the sleep-wake cycle seems to be bidirectional, while sleep shapes the rhythm of seizures, epileptic phenotype changes sleep architecture. Circadian factors and the sleep-wake states dependency have a potential as add-ons in seizures' forecasting. Stability of the rhythm of recurrent seizures in individual patients has been already used as a variable which refines existing algorithms for seizures' prediction. On the other hand, apart from successful pharmacological approach, circadian hygiene including sufficient sleep and avoidance of internal desynchronization or sleep loss, may be beneficial for patients with epilepsy in everyday management of seizures.

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“…Fewer reports describe biphasic patterns [ 6 ], or a peak around the middle of the day [ 1 ]. Those contradictory results have been reviewed by Bkasa et al, [ 7 ] who highlight the methodological differences between the studies that may contribute to the differences (number of patients, prospective or retrospective nature, specific populations, type of headache, use of medication). Recently, a study showed that migraine patients have a higher likelihood to be “morning larks” (i.e.…”

Section: Introductionmentioning

confidence: 99%

CGRP induces migraine-like symptoms in mice during both the active and inactive phases

et al. 2021

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Background Circadian patterns of migraine attacks have been reported by patients but remain understudied. In animal models, circadian phases are generally not taken into consideration. In particular, rodents are nocturnal animals, yet they are most often tested during their inactive phase during the day. This study aims to test the validity of CGRP-induced behavioral changes in mice by comparing responses during the active and inactive phases. Methods Male and female mice of the outbred CD1 strain were administered vehicle (PBS) or CGRP (0.1 mg/kg, i.p.) to induce migraine-like symptoms. Animals were tested for activity (homecage movement and voluntary wheel running), light aversive behavior, and spontaneous pain at different times of the day and night. Results Peripheral administration of CGRP decreased the activity of mice during the first hour after administration, induced light aversive behavior, and spontaneous pain during that same period of time. Both phenotypes were observed no matter what time of the day or night they were assessed. Conclusions A decrease in wheel activity is an additional clinically relevant phenotype observed in this model, which is reminiscent of the reduction in normal physical activity observed in migraine patients. The ability of peripheral CGRP to induce migraine-like symptoms in mice is independent of the phase of the circadian cycle. Therefore, preclinical assessment of migraine-like phenotypes can likely be done during the more convenient inactive phase of mice.

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Circadian Variation of Migraine Attack Onset: A Review of Clinical Studies

Cited by 18 publications

References 51 publications

Migraine and sleep disorders: a systematic review

Migraine and sleep disorders: a systematic review

Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy

CGRP induces migraine-like symptoms in mice during both the active and inactive phases

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